PMID- 37658968 OWN - NLM STAT- MEDLINE DCOM- 20230926 LR - 20240118 IS - 1568-5608 (Electronic) IS - 0925-4692 (Linking) VI - 31 IP - 5 DP - 2023 Oct TI - Meta-analysis of the anti-oxidative and anti-inflammatory effects of hypoglycaemic plant-derived medicines. PG - 2521-2539 LID - 10.1007/s10787-023-01315-9 [doi] AB - BACKGROUND: The pivotal role of oxidative stress and inflammation in the pathophysiology of type 2 diabetes mellitus (T2DM) has been firmly established. However, the evidence concerning hypoglycaemic medicinal plants' antioxidant and anti-inflammatory effects remains inconclusive due to inconsistencies in prior studies. To address this gap, our study aims to perform a comprehensive systematic review and meta-analysis of randomized controlled trials (RCTs) to consolidate previous research findings in this field. METHODS: We conducted a comprehensive search in the PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases to identify relevant English randomized controlled trials (RCTs). Our study adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. All eligible studies that evaluated concurrently the antioxidative and anti-inflammatory effects of hypoglycaemic plant-derived supplements on type 2 diabetes mellitus (T2DM) were included in the meta-analysis. The meta-analysis itself was carried out using both fixed and random effects models to synthesize the findings from the selected studies. RESULTS: Our study included 47 trials with a total of 2636 participants, both male and female, aged between 20 and 79 years, diagnosed with prediabetes, type 2 diabetes mellitus (T2DM), or metabolic syndrome. The meta-analysis revealed that plant-derived treatments, compared to placebos or other medicines, significantly improved oxidative stress (SMD = - 0.36, 95% CI - 0.64 to - 0.09), inflammation (SMD = - 0.47, 95% CI - 0.63 to - 0.31), total antioxidant capacity (SMD = 0.46, 95% CI 0.16-0.75), and antioxidant enzyme activity (SMD = 1.80, 95% CI 1.26-2.33). The meta-regression analysis showed that treatment duration exceeding 8 weeks significantly impacted the heterogeneity of the oxidative stress data. CONCLUSIONS: Several hypoglycaemic plant-based treatments appear to positively affect T2DM patients by concurrently lowering oxidative stress and inflammatory indicators and boosting antioxidant enzyme activity. CLINICAL TRAIL REGISTRY: PROSPERO ID: CRD42021226147. CI - (c) 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Azizi, Bayan AU - Azizi B AUID- ORCID: 0000-0002-1052-6810 AD - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. AD - Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Mohseni, Shahrzad AU - Mohseni S AUID- ORCID: 0000-0002-0694-7495 AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Tabatabaei-Malazy, Ozra AU - Tabatabaei-Malazy O AUID- ORCID: 0000-0003-0188-9721 AD - Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. tabatabaeiml@sina.tums.ac.ir. FAU - Esmaeili, Fataneh AU - Esmaeili F AUID- ORCID: 0000-0003-0047-4321 AD - Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AD - Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Khodaeian, Mehrnoosh AU - Khodaeian M AUID- ORCID: 0000-0001-6064-018X AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Qorbani, Mostafa AU - Qorbani M AUID- ORCID: 0000-0001-9465-7588 AD - Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. FAU - Nazeri, Elahe AU - Nazeri E AUID- ORCID: 0000-0003-0956-8375 AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Nouhi, Zahra AU - Nouhi Z AUID- ORCID: 0000-0003-4445-2423 AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. LA - eng GR - 1399-01-97-991/Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20230902 PL - Switzerland TA - Inflammopharmacology JT - Inflammopharmacology JID - 9112626 RN - 0 (Antioxidants) RN - 0 (Hypoglycemic Agents) RN - 0 (Anti-Inflammatory Agents) SB - IM MH - Humans MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - *Antioxidants/pharmacology/therapeutic use MH - Hypoglycemic Agents/pharmacology/therapeutic use MH - *Diabetes Mellitus, Type 2/drug therapy MH - Inflammation/drug therapy MH - Anti-Inflammatory Agents/pharmacology/therapeutic use OTO - NOTNLM OT - Clinical trial OT - Inflammation OT - Oxidative stress OT - Plant-derived OT - Systematic review OT - Type 2 diabetes mellitus EDAT- 2023/09/04 01:22 MHDA- 2023/09/26 13:43 CRDT- 2023/09/02 11:07 PHST- 2023/05/04 00:00 [received] PHST- 2023/07/31 00:00 [accepted] PHST- 2023/09/26 13:43 [medline] PHST- 2023/09/04 01:22 [pubmed] PHST- 2023/09/02 11:07 [entrez] AID - 10.1007/s10787-023-01315-9 [pii] AID - 10.1007/s10787-023-01315-9 [doi] PST - ppublish SO - Inflammopharmacology. 2023 Oct;31(5):2521-2539. doi: 10.1007/s10787-023-01315-9. Epub 2023 Sep 2.