PMID- 37659802
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20230904
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 320
DP  - 2023 Nov 15
TI  - Starch-based materials for drug delivery in the gastrointestinal tract-A review.
PG  - 121258
LID - S0144-8617(23)00723-3 [pii]
LID - 10.1016/j.carbpol.2023.121258 [doi]
AB  - Starch is a natural copolymer with unique physicochemical characteristics. 
      Historically, it has been physically, chemically, or enzymatically modified to 
      obtain ad-hoc functional properties for its use in different applications. In 
      this context, the use of starch-based materials in drug delivery systems (DDSs) 
      has gained great attention mainly because it is cheap, biodegradable, 
      biocompatible, and renewable. This paper reviews the state of the art in 
      starch-based materials design for their use in drug-controlled release with 
      internal stimulus responsiveness; i.e., pH, temperature, colonic microbiota, or 
      enzymes; specifically, those orally administered for its release in the 
      gastrointestinal tract (GIT). Physical-chemical principles in the design of these 
      materials taking into account their response to a particular stimulus are 
      discussed. The relationship between the type of DDSs structure, starch 
      modification routes, and the corresponding drug release profiles are 
      systematically analyzed. Furthermore, the challenges and prospects of 
      starch-based materials for their use in stimulus-responsive DDSs are also 
      debated.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Boldrini, Diego E
AU  - Boldrini DE
AD  - Planta Piloto de Ingenieria Quimica (PLAPIQUI), CONICET - Universidad Nacional 
      del Sur (UNS), Camino La Carrindanga km 7, 8000 Bahia Blanca, Argentina; 
      Departamento de Ingenieria Quimica, UNS, Avenida Alem 1253, 8000 Bahia Blanca, 
      Argentina. Electronic address: dboldrini@plapiqui.edu.ar.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230804
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 9005-25-8 (Starch)
SB  - IM
MH  - *Drug Delivery Systems
MH  - *Gastrointestinal Tract
MH  - Colon
MH  - Drug Liberation
MH  - Starch
OTO - NOTNLM
OT  - Drug delivery systems
OT  - Oral administration
OT  - Starch-based materials
OT  - Stimulus responsiveness
COIS- Declaration of competing interest The author declares that he has no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/09/03 00:41
MHDA- 2023/09/04 06:42
CRDT- 2023/09/02 20:59
PHST- 2023/05/08 00:00 [received]
PHST- 2023/07/15 00:00 [revised]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2023/09/04 06:42 [medline]
PHST- 2023/09/03 00:41 [pubmed]
PHST- 2023/09/02 20:59 [entrez]
AID - S0144-8617(23)00723-3 [pii]
AID - 10.1016/j.carbpol.2023.121258 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2023 Nov 15;320:121258. doi: 10.1016/j.carbpol.2023.121258. Epub 
      2023 Aug 4.