PMID- 37660897 OWN - NLM STAT- MEDLINE DCOM- 20231127 LR - 20240123 IS - 1878-1632 (Electronic) IS - 1529-9430 (Linking) VI - 23 IP - 12 DP - 2023 Dec TI - Risk factors for failure to achieve minimal clinically important difference following cervical disc replacement. PG - 1808-1816 LID - S1529-9430(23)03367-3 [pii] LID - 10.1016/j.spinee.2023.08.017 [doi] AB - BACKGROUND CONTEXT: While cervical disc replacement (CDR) has been emerging as a reliable and efficacious treatment option for degenerative cervical spine pathology, not all patients undergoing CDR will achieve minimal clinically important difference (MCID) in patient-reported outcome measures (PROMs) postoperatively-risk factors for failure to achieve MCID in PROMs following CDR have not been established. PURPOSE: To identify risk factors for failure to achieve MCID in Neck Disability Index (NDI, Visual Analog Scale (VAS) neck and arm following primary 1- or 2-level CDRs in the early and late postoperative periods. STUDY DESIGN: Retrospective review of prospectively collected data. PATIENT SAMPLE: Patients who had undergone primary 1- or 2-level CDR for the treatment of degenerative cervical pathology at a single institution with a minimum follow-up of 6 weeks between 2017 and 2022. OUTCOME MEASURES: Patient-reported outcomes: Neck disability index (NDI), Visual analog scale (VAS) neck and arm, MCID. METHODS: Minimal clinically important difference achievement rates for NDI, VAS-Neck, and VAS-Arm within early (within 3 months) and late (6 months to 2 years) postoperative periods were assessed based on previously established thresholds. Multivariate logistic regressions were performed for each PROM and evaluation period, with failure to achieve MCID assigned as the outcome variable, to establish models to identify risk factors for failure to achieve MCID and predictors for achievement of MCID. Predictor variables included in the analyses featured demographics, comorbidities, diagnoses/symptoms, and perioperative characteristics. RESULTS: A total of 154 patients met the inclusion criteria. The majority of patients achieved MCID for NDI, VAS-Neck, and VAS-Arm for both early and late postoperative periods-79% achieved MCID for at least one of the PROMs in the early postoperative period, while 80% achieved MCID for at least one of the PROMs in the late postoperative period. Predominant neck pain was identified as a risk factor for failure to achieve MCID for NDI in the early (OR: 3.13 [1.10-8.87], p-value: .032) and late (OR: 5.01 [1.31-19.12], p-value: .018) postoperative periods, and VAS-Arm for the late postoperative period (OR: 36.63 [3.78-354.56], p-value: .002). Myelopathy was identified as a risk factor for failure to achieve MCID for VAS-Neck in the early postoperative period (OR: 3.40 [1.08-10.66], p-value: .036). Anxiety was identified as a risk factor for failure to achieve MCID for VAS-Neck in the late postoperative period (OR: 6.51 [1.91-22.18], p-value: .003). CDR at levels C5C7 was identified as a risk factor for failure to achieve MCID in NDI for the late postoperative period (OR: 9.74 [1.43-66.34], p-value: .020). CONCLUSIONS: Our study identified several risk factors for failure to achieve MCID in common PROMs following CDR including predominant neck pain, myelopathy, anxiety, and CDR at levels C5-C7. These findings may help inform the approach to counseling patients on outcomes of CDR as the evidence suggests that those with the risk factors above may not improve as reliably after CDR. CI - Copyright (c) 2023. Published by Elsevier Inc. FAU - Mai, Eric AU - Mai E AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA. FAU - Shahi, Pratyush AU - Shahi P AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Lee, Ryan AU - Lee R AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Shinn, Daniel J AU - Shinn DJ AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA. FAU - Vaishnav, Avani AU - Vaishnav A AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Araghi, Kasra AU - Araghi K AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Singh, Nishtha AU - Singh N AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Maayan, Omri AU - Maayan O AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA. FAU - Tuma, Olivia C AU - Tuma OC AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Pajak, Anthony AU - Pajak A AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Asada, Tomoyuki AU - Asada T AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Korsun, Maximilian K AU - Korsun MK AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Singh, Sumedha AU - Singh S AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Kim, Yeo Eun AU - Kim YE AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA. FAU - Louie, Philip K AU - Louie PK AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Huang, Russel C AU - Huang RC AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Albert, Todd J AU - Albert TJ AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Dowdell, James AU - Dowdell J AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Sheha, Evan D AU - Sheha ED AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Iyer, Sravisht AU - Iyer S AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. FAU - Qureshi, Sheeraz A AU - Qureshi SA AD - Department of Spine Surgery, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021 USA. Electronic address: qureshis@hss.edu. LA - eng PT - Journal Article DEP - 20230901 PL - United States TA - Spine J JT - The spine journal : official journal of the North American Spine Society JID - 101130732 SB - IM MH - Humans MH - Neck Pain/etiology/surgery MH - Minimal Clinically Important Difference MH - Neck MH - Treatment Outcome MH - Cervical Vertebrae/surgery MH - Retrospective Studies MH - *Spinal Fusion/adverse effects MH - *Spinal Cord Diseases OTO - NOTNLM OT - Cervical disc replacement OT - Minimal clinically important difference OT - Neck disability index OT - Patient reported outcome measures OT - Visual analog scale COIS- Declarations of Competing Interest One or more of the authors declare financial or professional relationships on ICMJE-TSJ disclosure forms. EDAT- 2023/09/04 00:41 MHDA- 2023/11/27 12:43 CRDT- 2023/09/03 19:27 PHST- 2023/03/27 00:00 [received] PHST- 2023/08/24 00:00 [revised] PHST- 2023/08/29 00:00 [accepted] PHST- 2023/11/27 12:43 [medline] PHST- 2023/09/04 00:41 [pubmed] PHST- 2023/09/03 19:27 [entrez] AID - S1529-9430(23)03367-3 [pii] AID - 10.1016/j.spinee.2023.08.017 [doi] PST - ppublish SO - Spine J. 2023 Dec;23(12):1808-1816. doi: 10.1016/j.spinee.2023.08.017. Epub 2023 Sep 1.