PMID- 37662538
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230905
IS  - 2398-8835 (Electronic)
IS  - 2398-8835 (Linking)
VI  - 6
IP  - 9
DP  - 2023 Sep
TI  - The mediating role of quality of life on depression and medication adherence 
      among patients with type 2 diabetes mellitus: A cross-sectional study.
PG  - e1539
LID - 10.1002/hsr2.1539 [doi]
LID - e1539
AB  - BACKGROUND AND AIM: Patients living with diabetes mellitus have a high burden of 
      psychological distress such as depression and anxiety as well as impaired quality 
      of life, which may negatively impact their adherence to medications, glucose 
      control, and health-related costs.This study assessed the impact of quality of 
      life and depression on medication adherence among patients with type 2 diabetes 
      (type 2 diabetes mellitus [T2DM]) in a tertiary care setting in Ghana. METHODS: 
      The study was a cross-sectional study involving 238 patients with diabetes aged 
      18 years and above. Validated tools were used to assess medication adherence, 
      depressive symptoms, and quality of life. Structural Equation Modeling was 
      adopted to examine the mediation effect of quality of life on the relationship 
      between depression and medication adherence among participants. RESULTS: The mean 
      age of the participants was 58.82 +/- 13.49, and 169 (71.0%) out of a total of 238 
      respondents were females. Depression had a significant direct relationship with 
      the quality of life of respondents [abeta (95% confidence interval, CI) = -0.20 
      (-0.03, -0.00), p < 0.05; -0.21 (-0.41, -0.01) p < 0.05, respectively] and 
      indirect relationship with quality of life [abeta (95% CI) = -0.01 (-0.02, -0.004) 
      p < 0.001]. Educational status and religion both showed a significant indirect 
      relationship with quality of life [abeta (95% CI) = 0.06 (0.07, 0.12), p < 0.05; 
      0.18 (0.01, 0.35) p < 0.05, respectively]. The mediating effect of quality of 
      life on the relationship between depression and medication adherence was 
      significant (Sobel = -3.19, p < 0.001). CONCLUSION: Depression, medication 
      adherence, and quality of life were higher among older adults with T2DM. 
      Depression was also found to have a strong negative association with both 
      medication adherence and quality of life. Interventions to screen for depression 
      and to improve the quality of life in patients living with diabetes are also 
      recommended and this should go beyond the provision of standard treatments to 
      explore further the mechanisms of this relationships.
CI  - (c) 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.
FAU - Yorke, Ernest
AU  - Yorke E
AUID- ORCID: 0000-0003-4257-7492
AD  - Department of Medicine & Therapeutics, University of Ghana Medical School, 
      College of Health Sciences University of Ghana Accra Ghana.
FAU - Boima, Vincent
AU  - Boima V
AD  - Department of Medicine & Therapeutics, University of Ghana Medical School, 
      College of Health Sciences University of Ghana Accra Ghana.
FAU - Ganu, Vincent
AU  - Ganu V
AD  - Department of Medicine and Cardiothoracic Unit Korle-Bu Teaching Hospital Accra 
      Ghana.
FAU - Tetteh, John
AU  - Tetteh J
AD  - Department of Community Health, University of Ghana Medical School, College of 
      Health Sciences University of Ghana Accra Ghana.
FAU - Twumasi, Louisa
AU  - Twumasi L
AD  - Department of Psychology University of Ghana Accra Ghana.
FAU - Ekem-Ferguson, George
AU  - Ekem-Ferguson G
AUID- ORCID: 0000-0002-9293-6812
AD  - Department of Psychology University of Ghana Accra Ghana.
AD  - National Cardiothoracic Center Korle Bu Teaching Hospital Accra Ghana.
AD  - Department of Psychiatry, University of Ghana Medical School, College of Health 
      Sciences University of Ghana Accra Ghana.
FAU - Kretchy, Irene
AU  - Kretchy I
AD  - Department of Psychology University of Ghana Accra Ghana.
FAU - Mate-Kole, Christopher C
AU  - Mate-Kole CC
AD  - Department of Psychology University of Ghana Accra Ghana.
AD  - Department of Psychiatry, University of Ghana Medical School, College of Health 
      Sciences University of Ghana Accra Ghana.
AD  - Center for Ageing Studies, College of Humanities University of Ghana.
LA  - eng
PT  - Journal Article
DEP - 20230831
PL  - United States
TA  - Health Sci Rep
JT  - Health science reports
JID - 101728855
PMC - PMC10469042
OTO - NOTNLM
OT  - depression
OT  - medication adherence
OT  - quality of life
OT  - type 2 diabetes
COIS- The authors declare no conflicts of interest.
EDAT- 2023/09/04 06:43
MHDA- 2023/09/04 06:44
PMCR- 2023/08/31
CRDT- 2023/09/04 04:45
PHST- 2023/05/15 00:00 [received]
PHST- 2023/07/27 00:00 [revised]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/09/04 06:44 [medline]
PHST- 2023/09/04 06:43 [pubmed]
PHST- 2023/09/04 04:45 [entrez]
PHST- 2023/08/31 00:00 [pmc-release]
AID - HSR21539 [pii]
AID - 10.1002/hsr2.1539 [doi]
PST - epublish
SO  - Health Sci Rep. 2023 Aug 31;6(9):e1539. doi: 10.1002/hsr2.1539. eCollection 2023 
      Sep.