PMID- 37662596
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230905
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - Physicochemical properties of superfine grinding-microwave modified artichoke 
      soluble dietary fiber and their alleviation of alcoholic fatty liver in mice.
PG  - 1253963
LID - 10.3389/fnut.2023.1253963 [doi]
LID - 1253963
AB  - The effects of superfine grinding (SG) and microwave treatment (MT) on the 
      structure and physicochemical properties of artichoke soluble dietary fiber 
      (ASDF) and its protective effects on mice with alcoholic fatty liver (AFL) were 
      studied. We compared the changes in structural characteristics and 
      physicochemical properties of ASDF, SG-ASDF (ASDF treated by SG), MT-ASDF (ASDF 
      treated by MT), and CM-ASDF (ASDF treated by SG and MT). Moreover, we evaluated 
      the effects of the obtained ASDF on the growth characteristics, blood lipid 
      levels, and liver of mice with AFL. Our results of the study showed that CM-ASDF 
      had a more concentrated and uniform particle size, a higher extraction rate of 
      ASDF and significantly improved water-holding capacity (WHC), oil-holding 
      capacity (OHC) and water swelling capacity (WSC) of ASDF (p < 0.05). After the 
      ASDF intervention, mice with AFL exhibited a significant improvement in body 
      lipid levels and reduce liver inflammation. Specifically, aspartate 
      aminotransferase (AST), alanine aminotransferase (ALT), malonaldehyde (MDA), 
      Tumor necrosis factor-alpha (TNF-alpha) and Interleukin-6 (IL-6) were significantly 
      decreased, while superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) 
      were significantly increased (p < 0.05). And the hematoxylin-eosin (HE) staining 
      results showed significant improvement of hepatic steatosis in mice with AFL. In 
      summary, our study found that both SG and MT could improve the structure and 
      physicochemical properties of ASDF, with CM-ASDF being the most effective. 
      Additionally, CM-ASDF was selected to continue the investigation and demonstrated 
      an excellent protective effect on mice with AFL, with the high dose group 
      (H-ASDF) showing the greatest benefit. These findings provided some new insights 
      for future comprehensive utilization of ASDF and drug development for the 
      treatment of AFL.
CI  - Copyright (c) 2023 Wang, He, Zhang, Zhu and Huang.
FAU - Wang, Yayi
AU  - Wang Y
AD  - School of Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, China.
AD  - Hunan Key Laboratory of Processed Food for Special Medical Purpose, Changsha, 
      China.
FAU - He, Bian
AU  - He B
AD  - School of Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, China.
AD  - Hunan Key Laboratory of Processed Food for Special Medical Purpose, Changsha, 
      China.
FAU - Zhang, Linwei
AU  - Zhang L
AD  - School of Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, China.
AD  - Hunan Key Laboratory of Processed Food for Special Medical Purpose, Changsha, 
      China.
FAU - Zhu, Renwei
AU  - Zhu R
AD  - School of Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, China.
AD  - Hunan Key Laboratory of Processed Food for Special Medical Purpose, Changsha, 
      China.
FAU - Huang, Liang
AU  - Huang L
AD  - School of Food Science and Engineering, Central South University of Forestry and 
      Technology, Changsha, China.
AD  - Hunan Key Laboratory of Processed Food for Special Medical Purpose, Changsha, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20230816
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10473878
OTO - NOTNLM
OT  - alcoholic fatty liver
OT  - artichoke
OT  - compound modification
OT  - physicochemical properties
OT  - soluble dietary fiber
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/04 06:43
MHDA- 2023/09/04 06:44
PMCR- 2023/01/01
CRDT- 2023/09/04 04:46
PHST- 2023/07/06 00:00 [received]
PHST- 2023/08/04 00:00 [accepted]
PHST- 2023/09/04 06:44 [medline]
PHST- 2023/09/04 06:43 [pubmed]
PHST- 2023/09/04 04:46 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1253963 [doi]
PST - epublish
SO  - Front Nutr. 2023 Aug 16;10:1253963. doi: 10.3389/fnut.2023.1253963. eCollection 
      2023.