PMID- 37662614
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230905
IS  - 2542-4823 (Electronic)
IS  - 2542-4823 (Linking)
VI  - 7
IP  - 1
DP  - 2023
TI  - Sleep Dysregulation Is Associated with (18)F-FDG PET and Cerebrospinal Fluid 
      Biomarkers in Alzheimer's Disease.
PG  - 845-854
LID - 10.3233/ADR-220111 [doi]
AB  - BACKGROUND: Sleep impairment has been commonly reported in Alzheimer's disease 
      (AD) patients. The association between sleep dysregulation and AD biomarkers has 
      been separately explored in mild cognitive impairment (MCI) and AD patients. 
      OBJECTIVE: The present study investigated cerebrospinal-fluid (CSF) and 
      (18)F-fluoro-deoxy-glucose positron emission tomography ((18)F-FDG-PET) 
      biomarkers in MCI and AD patients in order to explore their association with 
      sleep parameters measured with polysomnography (PSG). METHODS: MCI and AD 
      patients underwent PSG, (18)F-FDG-PET, and CSF analysis for detecting and 
      correlating these biomarkers with sleep architecture. RESULTS: Thirty-five 
      patients were included in the study (9 MCI and 26 AD patients). (18)F-FDG uptake 
      in left Brodmann area 31 (owing to the posterior cingulate cortex) correlated 
      negatively with REM sleep latency (p = 0.013) and positively with REM sleep 
      (p = 0.033). (18)F-FDG uptake in the hippocampus was negatively associated with 
      sleep onset latency (p = 0.041). Higher CSF orexin levels were associated with 
      higher sleep onset latency (p = 0.042), Non-REM stage 1 of sleep (p = 0.031), 
      wake after sleep onset (p = 0.028), and lower sleep efficiency (p = 0.045). CSF 
      levels of Abeta(42) correlated negatively with the wake bouts index (p = 0.002). CSF 
      total-tau and phosphorylated tau levels correlated positively with total sleep 
      time (p = 0.045) and time in bed (p = 0.031), respectively. CONCLUSION: Sleep 
      impairment, namely sleep fragmentation, REM sleep dysregulation, and difficulty 
      in initiating sleep correlates with AD biomarkers, suggesting an effect of sleep 
      on the pathological processes in different AD stages. Targeting sleep for 
      counteracting the AD pathological processes represents a timely need for 
      clinicians and researchers.
CI  - (c) 2023 - The authors. Published by IOS Press.
FAU - Fernandes, Mariana
AU  - Fernandes M
AD  - Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
FAU - Chiaravalloti, Agostino
AU  - Chiaravalloti A
AD  - Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, 
      Italy.
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Nuccetelli, Marzia
AU  - Nuccetelli M
AD  - Department of Clinical Biochemistry and Molecular Biology, University of Rome 
      "Tor Vergata", Rome, Italy.
FAU - Placidi, Fabio
AU  - Placidi F
AD  - Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
AD  - Sleep Medicine Centre, Neurology Unit, University Hospital of Rome "Tor Vergata", 
      Rome, Italy.
FAU - Izzi, Francesca
AU  - Izzi F
AD  - Sleep Medicine Centre, Neurology Unit, University Hospital of Rome "Tor Vergata", 
      Rome, Italy.
FAU - Camedda, Riccardo
AU  - Camedda R
AD  - Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, 
      Italy.
FAU - Bernardini, Sergio
AU  - Bernardini S
AD  - Department of Clinical Biochemistry and Molecular Biology, University of Rome 
      "Tor Vergata", Rome, Italy.
FAU - Sancesario, Giuseppe
AU  - Sancesario G
AD  - Sleep Medicine Centre, Neurology Unit, University Hospital of Rome "Tor Vergata", 
      Rome, Italy.
FAU - Schillaci, Orazio
AU  - Schillaci O
AD  - Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, 
      Italy.
FAU - Mercuri, Nicola Biagio
AU  - Mercuri NB
AD  - Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
AD  - Sleep Medicine Centre, Neurology Unit, University Hospital of Rome "Tor Vergata", 
      Rome, Italy.
FAU - Liguori, Claudio
AU  - Liguori C
AUID- ORCID: 0000-0003-2845-1332
AD  - Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
AD  - Sleep Medicine Centre, Neurology Unit, University Hospital of Rome "Tor Vergata", 
      Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230810
PL  - Netherlands
TA  - J Alzheimers Dis Rep
JT  - Journal of Alzheimer's disease reports
JID - 101705500
PMC - PMC10473116
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - biomarkers
OT  - brain
OT  - cerebrospinal fluid
OT  - dementia
OT  - orexin
OT  - positron emission tomography
OT  - sleep
COIS- The authors report no conflict of interest.
EDAT- 2023/09/04 06:42
MHDA- 2023/09/04 06:43
PMCR- 2023/08/10
CRDT- 2023/09/04 04:46
PHST- 2022/12/22 00:00 [received]
PHST- 2023/07/11 00:00 [accepted]
PHST- 2023/09/04 06:43 [medline]
PHST- 2023/09/04 06:42 [pubmed]
PHST- 2023/09/04 04:46 [entrez]
PHST- 2023/08/10 00:00 [pmc-release]
AID - ADR220111 [pii]
AID - 10.3233/ADR-220111 [doi]
PST - epublish
SO  - J Alzheimers Dis Rep. 2023 Aug 10;7(1):845-854. doi: 10.3233/ADR-220111. 
      eCollection 2023.