PMID- 37663228
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230905
IS  - 2692-4609 (Electronic)
IS  - 2692-4609 (Linking)
VI  - 4
IP  - 1
DP  - 2024 Apr
TI  - Morphological change of foveolar-type gastric adenocarcinoma after proton pump 
      inhibitor discontinuation in a short time period: A case report.
PG  - e293
LID - 10.1002/deo2.293 [doi]
LID - e293
AB  - A 37-year-old man with systemic lupus erythematosus underwent 
      esophagogastroduodenoscopy as a screening examination for anemia and bloody 
      stool. A semi-pedunculated edematous lobular polyp of 25 mm in size was detected 
      in the greater curvature of the upper gastric body. At that time, a definitive 
      diagnosis of cancer could not be made based on a biopsy specimen from the lesion. 
      Since the patient was on proton pump inhibitor (PPI) for a long time to prevent 
      peptic ulceration due to prolonged prednisolone administration for systemic lupus 
      erythematosus, we diagnosed the lesion as a PPI-associated hyperplastic polyp and 
      switched lansoprazole to famotidine. Two months later, esophagogastroduodenoscopy 
      revealed that the polyp had decreased in size to 8 mm, whereas the biopsy 
      specimen led to a histological diagnosis of gastric cancer. The polyp was removed 
      by endoscopic submucosal dissection. Immunohistochemistry revealed that the tumor 
      cells were positive for MUC5AC, but negative for MUC2 and MUC6, leading to a 
      final diagnosis of foveolar-type gastric adenocarcinoma. In conclusion, we may 
      suggest that PPI induces reversible morphological changes in foveolar-type 
      gastric adenocarcinoma. Furthermore, short-term follow-up of polypoid lesions 
      should be prepared, considering tumor comorbidity with morphological changes 
      during long-term PPI usage.
CI  - (c) 2023 The Authors. DEN Open published by John Wiley & Sons Australia, Ltd on 
      behalf of Japan Gastroenterological Endoscopy Society.
FAU - Igarashi, Shohei
AU  - Igarashi S
AUID- ORCID: 0000-0002-0660-7327
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Hanabata, Norihiro
AU  - Hanabata N
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Furusawa, Keisuke
AU  - Furusawa K
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Suto, Shinya
AU  - Suto S
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Satake, Miwa
AU  - Satake M
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Shimaya, Koji
AU  - Shimaya K
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Kanazawa, Kosuke
AU  - Kanazawa K
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Numao, Hiroshi
AU  - Numao H
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Munakata, Masaki
AU  - Munakata M
AD  - Department of Gastroenterology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Kurotaki, Hidekachi
AU  - Kurotaki H
AD  - Department of Pathology Aomori Prefectural Central Hospital Aomori Japan.
FAU - Sakuraba, Hirotake
AU  - Sakuraba H
AD  - Department of Gastroenterology and Hematology Hirosaki University Graduate School 
      of Medicine Aomori Japan.
FAU - Yoshida, Shigeaki
AU  - Yoshida S
AD  - Aomori Prefectural Hospital Administration Aomori Japan.
LA  - eng
PT  - Case Reports
DEP - 20230901
PL  - Australia
TA  - DEN Open
JT  - DEN open
JID - 9918317682706676
PMC - PMC10474311
OTO - NOTNLM
OT  - endoscopic submucosal dissection
OT  - gastric cancer
OT  - immunohistochemistry
OT  - morphology
OT  - proton pump inhibitor
COIS- None.
EDAT- 2023/09/04 06:42
MHDA- 2023/09/04 06:43
PMCR- 2023/09/01
CRDT- 2023/09/04 04:56
PHST- 2023/06/07 00:00 [received]
PHST- 2023/08/16 00:00 [revised]
PHST- 2023/08/19 00:00 [accepted]
PHST- 2023/09/04 06:43 [medline]
PHST- 2023/09/04 06:42 [pubmed]
PHST- 2023/09/04 04:56 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - DEO2293 [pii]
AID - 10.1002/deo2.293 [doi]
PST - epublish
SO  - DEN Open. 2023 Sep 1;4(1):e293. doi: 10.1002/deo2.293. eCollection 2024 Apr.