PMID- 37666381
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240102
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 44
DP  - 2023 Dec
TI  - Evaluation of optic coherence tomography findings in patients with inflammatory 
      bowel disease.
PG  - 103788
LID - S1572-1000(23)00515-X [pii]
LID - 10.1016/j.pdpdt.2023.103788 [doi]
AB  - BACKGROUND: Ocular complications are known to appear in inflammatory bowel 
      disease (IBD). Among these, posterior segment complications can lead to 
      substantial morbidity. The aim of the study is to evaluate the retinal nerve 
      fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), and macula 
      thickness measurement in patients with IBD. METHODS: A total of 118 patients with 
      IBD (42 Crohn's disease (CD), 76 ulcerative colitis (UC)) and 52 healthy subjects 
      were included in the study. RNFL, GCIPL, and macula thickness were measured using 
      spectral-domain optical coherence tomography (SD-OCT). RESULTS: The central 
      macular thickness was increased, mean and all superior quadrants of GCIPL 
      thickness measurements were significantly decreased, but RNFL thickness wasn't 
      changed in CD compared to healthy subjects. Although the central macular 
      thickness increased, no change was observed in mean RNFL and GCIPL in UC compared 
      to healthy subjects. Mean RNFL, GCIPL, and macular thickness did not differ 
      during the remission and active phases of the disease in IBD. There was no 
      difference in RNFL, GCIPL, and macular thicknesses in CD patients in terms of the 
      location and behavior of the disease. A significant thickness increase was found 
      in extensive type UC for inferior RNFL value compared to the left side and 
      proctitis. CONCLUSIONS: IBD may cause an increase in macular thickness. This 
      finding may be related to the inflammation or ischemia of the retina. The use of 
      SD-OCT in ophthalmologic examination in patients with IBD may enable early 
      detection of retinal changes and alert the clinician to complications of IBD.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Coskun, Cigdem
AU  - Coskun C
AD  - Department of Ophthalmology, Ankara Bilkent City Hospital, Ankara, Turkey. 
      Electronic address: drcigdem@hotmail.com.
FAU - Coskun, Yusuf
AU  - Coskun Y
AD  - Department of Gastroenterology, University of Health Sciences, Ankara Etlik City 
      Hospital, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230904
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Humans
MH  - Retinal Ganglion Cells
MH  - Nerve Fibers
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents
MH  - Tomography, Optical Coherence/methods
MH  - *Inflammatory Bowel Diseases/complications/diagnostic imaging
OTO - NOTNLM
OT  - Crohn's disease
OT  - Ganglion cell-inner plexiform layer
OT  - Inflammatory bowel disease
OT  - Macula thickness
OT  - Optical coherence tomography
OT  - Retinal nerve fiber layer
OT  - Ulcerative colitis
COIS- Declaration of Competing Interest The authors declare no conflict of interest for 
      this article.
EDAT- 2023/09/05 00:41
MHDA- 2023/12/25 06:43
CRDT- 2023/09/04 19:20
PHST- 2023/05/06 00:00 [received]
PHST- 2023/08/22 00:00 [revised]
PHST- 2023/09/01 00:00 [accepted]
PHST- 2023/12/25 06:43 [medline]
PHST- 2023/09/05 00:41 [pubmed]
PHST- 2023/09/04 19:20 [entrez]
AID - S1572-1000(23)00515-X [pii]
AID - 10.1016/j.pdpdt.2023.103788 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Dec;44:103788. doi: 
      10.1016/j.pdpdt.2023.103788. Epub 2023 Sep 4.