PMID- 37666585
OWN - NLM
STAT- MEDLINE
DCOM- 20230906
LR  - 20230906
IS  - 1095-9939 (Electronic)
IS  - 0048-3575 (Linking)
VI  - 195
DP  - 2023 Sep
TI  - Exploring the repairing mechanisms of reduced graphene oxide (rGo) on the 
      dysregulation of Xenopus Laevis larva hypothalamus-pituitary-thyroid (HPT) axis 
      caused by chiral triazole fungicide metconazole.
PG  - 105529
LID - S0048-3575(23)00194-3 [pii]
LID - 10.1016/j.pestbp.2023.105529 [doi]
AB  - Replacing chair fungicide racemate marketed product by its enantiomer with high 
      activity and low environmental risk for application is a more environmentally 
      friendly methods to control crop diseases. Moreover, carbon-based nanomaterials, 
      with the desirable chemical and mechanical properties, exhibits latent reduce 
      fungicide toxicity capability, while the mechanism is still poorly understood. 
      Therefore, the present study characterized the toxicity of rac-metconazole (Mez; 
      (1RS,5RS;1RS,5SR)-5-(4-chlorobenzyl)-2,2-dimethyl-1-(1H)) and its two 
      cis-enantiomers as well as the repairing effect of reduced graphene oxide (rGo) 
      on Xenopus Laevis larva by examining growth appearance indexes, Mez 
      bioaccumulation, and hypothalamus-pituitary-thyroid (HPT) axis related hormone 
      contents and gene expression after 14 and 28 days exposure. Compared with two 
      cis-Mez, rac-Mez was preferentially bioaccumulated in tadpoles, and rac-Mez 
      treatment showed a higher toxicity effect on tadpole including growth stage and 
      body weight inhibition by dysregulating tadpole thyroid stimulating hormone (TSH) 
      and thyroid hormone (TH) contents and related gene expression. Enantioselectivity 
      was observed in two cis-Mez treatments. Compared with R,S-Mez, S,R-Mez treatment 
      showed more severe damage on tadpole HPT axis related physiological and 
      biochemical processes. rGo could effectively decrease the toxicity of Mez, 
      especially shown the capacity of repairing the hormone dysregulation caused by 
      R,S-Mez treatment. Moreover, the addition of rGo can decrease the bioaccumulation 
      of Mez in tadpoles. Therefore, R,S-Mez is less toxic to Xenopus Laevis larva 
      growth, and its toxicity could be effectively repaired by the addition of rGO.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Deng, Yue
AU  - Deng Y
AD  - Interdisciplinary Research Center for Agriculture Green Development in Yangtze 
      River Basin, College of Resources and Environment, Southwest University, 
      Chongqing 400715, China.
FAU - Zheng, Meiling
AU  - Zheng M
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing 100193, 
      China.
FAU - Liu, Rui
AU  - Liu R
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing 100193, 
      China.
FAU - Zeng, Haixia
AU  - Zeng H
AD  - Interdisciplinary Research Center for Agriculture Green Development in Yangtze 
      River Basin, College of Resources and Environment, Southwest University, 
      Chongqing 400715, China.
FAU - Diao, Jingling
AU  - Diao J
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing 100193, 
      China.
FAU - Xiao, Ran
AU  - Xiao R
AD  - Interdisciplinary Research Center for Agriculture Green Development in Yangtze 
      River Basin, College of Resources and Environment, Southwest University, 
      Chongqing 400715, China.
FAU - Su, Xiaoxuan
AU  - Su X
AD  - Interdisciplinary Research Center for Agriculture Green Development in Yangtze 
      River Basin, College of Resources and Environment, Southwest University, 
      Chongqing 400715, China. Electronic address: xuangood@swu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230711
PL  - United States
TA  - Pestic Biochem Physiol
JT  - Pesticide biochemistry and physiology
JID - 1301573
RN  - 0 (graphene oxide)
RN  - A2F791945Q (metconazole)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Triazoles)
SB  - IM
MH  - Animals
MH  - *Fungicides, Industrial/toxicity
MH  - Thyroid Gland
MH  - Xenopus laevis
MH  - Triazoles/toxicity
MH  - Larva
OTO - NOTNLM
OT  - Enantioselectivity
OT  - Endocrine disruption
OT  - Metconazole
OT  - Reduced graphene oxide
EDAT- 2023/09/05 00:41
MHDA- 2023/09/06 06:42
CRDT- 2023/09/04 20:56
PHST- 2023/06/07 00:00 [received]
PHST- 2023/07/04 00:00 [revised]
PHST- 2023/07/10 00:00 [accepted]
PHST- 2023/09/06 06:42 [medline]
PHST- 2023/09/05 00:41 [pubmed]
PHST- 2023/09/04 20:56 [entrez]
AID - S0048-3575(23)00194-3 [pii]
AID - 10.1016/j.pestbp.2023.105529 [doi]
PST - ppublish
SO  - Pestic Biochem Physiol. 2023 Sep;195:105529. doi: 10.1016/j.pestbp.2023.105529. 
      Epub 2023 Jul 11.