PMID- 37667546
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240502
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 21
IP  - 1
DP  - 2024 Jan
TI  - Risk factors of foot ulcers in patients with end-stage renal disease on dialysis: 
      A meta-analysis.
PG  - e14348
LID - 10.1111/iwj.14348 [doi]
LID - e14348
AB  - The present study aims to assess the risk factors for foot ulcers in patients 
      undergoing dialysis for end-stage renal disease (ESRD) and to provide 
      evidence-based guidance for prevention and treatment. A systematic search was 
      conducted on PubMed, EMBASE, Cochrane Library, China National Knowledge 
      Infrastructure, Chinese Biomedical Literature Database and Wanfang Data from the 
      database inception until May 2023 to identify relevant studies investigating the 
      risk factors for foot ulcers in dialysis patients with ESRD. Two independent 
      researchers conducted the literature screening and data extraction. The 
      meta-analysis was performed using STATA 17.0 software. Ultimately, six articles 
      comprising 1620 patients were included for analysis. The meta-analysis revealed 
      that male (OR, 1.464; 95% CI: 1.082-1.980, p = 0.013), hypertension (OR, 1.781; 
      95% CI: 1.293-2.4550, p < 0.001), peripheral artery disease (PAD) (OR, 5.014; 95% 
      CI: 2.514-9.998, p < 0.001), type 1 diabetes mellitus (T1DM) (OR, 2.993; 95% CI: 
      1.477-6.065, p = 0.002) and type 2 diabetes mellitus (T2DM) (OR, 2.498; 95% 
      CI:1.466-4.256, p = 0.001) were risk factors for foot ulcers in dialysis patients 
      with ESRD. Conversely, the female sex (OR, 0.683; 95% CI: 0.505-0.924, p = 0.013) 
      was a protective factor against foot ulcers. Our analysis revealed that male sex, 
      hypertension, PAD, T1DM and T2DM were risk factors for foot ulcers in patients 
      undergoing dialysis for ESRD. Conversely, the female sex was a protective factor 
      against foot ulcers. Therefore, it is crucial to strengthen health education that 
      targets patients with these risk factors and regularly screen high-risk 
      individuals. Early detection and treatment can help delay disease progression.
CI  - (c) 2023 The Authors. International Wound Journal published by Medicalhelplines.com 
      Inc and John Wiley & Sons Ltd.
FAU - Yan, Shanshan
AU  - Yan S
AD  - Department of Nephrology, Fourth Medical Center of Chinese PLA General Hospital, 
      Beijing, China.
FAU - Yao, Dongfang
AU  - Yao D
AD  - Department of Emergency Medicine, Fourth Medical Center of Chinese PLA General 
      Hospital, Beijing, China.
FAU - Wang, Ya
AU  - Wang Y
AD  - Department of Nephrology, Fourth Medical Center of Chinese PLA General Hospital, 
      Beijing, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Nephrology, First Medical Center of Chinese PLA General Hospital, 
      Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20230904
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Diabetes Mellitus, Type 1/complications
MH  - Diabetes Mellitus, Type 2/complications
MH  - Diabetic Foot/etiology
MH  - *Foot Ulcer/etiology
MH  - Hypertension/epidemiology
MH  - *Kidney Failure, Chronic/complications/therapy
MH  - Peripheral Arterial Disease/complications
MH  - *Renal Dialysis
MH  - Risk Factors
PMC - PMC10782048
OTO - NOTNLM
OT  - dialysis
OT  - end-stage renal disease
OT  - foot ulcers
OT  - meta-analysis
OT  - risk factors
COIS- The authors declare no conflicts of interest.
EDAT- 2023/09/05 06:42
MHDA- 2024/01/29 06:44
PMCR- 2023/09/04
CRDT- 2023/09/05 02:20
PHST- 2023/07/27 00:00 [revised]
PHST- 2023/07/05 00:00 [received]
PHST- 2023/07/29 00:00 [accepted]
PHST- 2024/01/29 06:44 [medline]
PHST- 2023/09/05 06:42 [pubmed]
PHST- 2023/09/05 02:20 [entrez]
PHST- 2023/09/04 00:00 [pmc-release]
AID - IWJ14348 [pii]
AID - 10.1111/iwj.14348 [doi]
PST - ppublish
SO  - Int Wound J. 2024 Jan;21(1):e14348. doi: 10.1111/iwj.14348. Epub 2023 Sep 4.