PMID- 37667787
OWN - NLM
STAT- MEDLINE
DCOM- 20230906
LR  - 20230906
IS  - 1177-8881 (Electronic)
IS  - 1177-8881 (Linking)
VI  - 17
DP  - 2023
TI  - Recent Research Advances in Nano-Based Drug Delivery Systems for Local 
      Anesthetics.
PG  - 2639-2655
LID - 10.2147/DDDT.S417051 [doi]
AB  - From a clinical perspective, local anesthetics have rather widespread application 
      in regional blockade for surgery, postoperative analgesia, acute/chronic pain 
      control, and even cancer treatments. However, a number of disadvantages are 
      associated with traditional local anesthetic agents as well as routine drug 
      delivery administration ways, such as neurotoxicity, short half-time, and 
      non-sustained release, thereby limiting their application in clinical practice. 
      Successful characterization of drug delivery systems (DDSs) for individual local 
      anesthetic agents can support to achieve more efficient drug release and 
      prolonged duration of action with reduced systemic toxicity. Different types of 
      DDSs involving various carriers have been examined, including micromaterials, 
      nanomaterials, and cyclodextrin. Among them, nanotechnology-based delivery 
      approaches have significantly developed in the last decade due to the low 
      systemic toxicity and the greater efficacy of non-conventional local anesthetics. 
      Multiple nanosized materials, including polymeric, lipid (solid lipid 
      nanoparticles, nanostructured lipid carriers, and nanoemulsions), metallic, 
      inorganic non-metallic, and hybrid nanoparticles, offer a safe, localized, and 
      long-acting solution for pain management and tumor therapy. This review provides 
      a brief synopsis of different nano-based DDSs for local anesthetics with variable 
      sizes and structural morphology, such as nanocapsules and nanospheres. Recent 
      original research utilizing nanotechnology-based delivery systems is particularly 
      discussed, and the progress and strengths of these DDSs are highlighted. A 
      specific focus of this review is the comparison of various nano-based DDSs for 
      local anesthetics, which can offer additional indications for their further 
      improvement. All in all, nano-based DDSs with unique advantages provide a novel 
      direction for the development of safer and more effective local anesthetic 
      formulations.
CI  - (c) 2023 Ma et al.
FAU - Ma, He
AU  - Ma H
AD  - Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, 
      People's Republic of China.
FAU - Pan, Zhenxiang
AU  - Pan Z
AD  - Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, 
      People's Republic of China.
FAU - Lai, Bingjie
AU  - Lai B
AD  - Department of Intensive Care Unit, The Second Hospital of Jilin University, 
      Changchun, People's Republic of China.
FAU - Zan, Chunfang
AU  - Zan C
AD  - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, 
      Taiyuan, People's Republic of China.
AD  - Collaborative Innovation Center for Molecular Imaging of Precision Medicine, 
      Shanxi Medical University, Taiyuan, People's Republic of China.
FAU - Liu, He
AU  - Liu H
AD  - Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230830
PL  - New Zealand
TA  - Drug Des Devel Ther
JT  - Drug design, development and therapy
JID - 101475745
RN  - 0 (Anesthetics, Local)
RN  - 0 (Lipids)
SB  - IM
MH  - *Anesthetics, Local
MH  - *Anesthesia, Local
MH  - Pain Management
MH  - Drug Delivery Systems
MH  - Lipids
PMC - PMC10475288
OTO - NOTNLM
OT  - drug delivery system
OT  - local anesthetics
OT  - nanocarriers
OT  - nanoparticles
OT  - nanotechnology
OT  - pain
COIS- All the authors declare no competing interests in this work.
EDAT- 2023/09/05 06:42
MHDA- 2023/09/06 06:42
PMCR- 2023/08/30
CRDT- 2023/09/05 03:37
PHST- 2023/04/13 00:00 [received]
PHST- 2023/08/01 00:00 [accepted]
PHST- 2023/09/06 06:42 [medline]
PHST- 2023/09/05 06:42 [pubmed]
PHST- 2023/09/05 03:37 [entrez]
PHST- 2023/08/30 00:00 [pmc-release]
AID - 417051 [pii]
AID - 10.2147/DDDT.S417051 [doi]
PST - epublish
SO  - Drug Des Devel Ther. 2023 Aug 30;17:2639-2655. doi: 10.2147/DDDT.S417051. 
      eCollection 2023.