PMID- 37668684 OWN - NLM STAT- MEDLINE DCOM- 20240124 LR - 20240229 IS - 1432-5233 (Electronic) IS - 0940-5429 (Linking) VI - 61 IP - 1 DP - 2024 Jan TI - Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults. PG - 43-52 LID - 10.1007/s00592-023-02175-z [doi] AB - AIMS: Type 2 diabetes mellitus (T2DM) and hypertension are common high-incidence diseases, closely related, and have common pathogenic basis such as oxidative stress. Casein kinase 2 interacting protein-1 (CKIP-1) and low-density lipoprotein receptor (LOX-1) are considered to be important factors affect the level of oxidative stress in the body. The main purpose of this study was to explore the relationship between CKIP-1 (rs6693817 A > T, rs2306235 C > G) and LOX-1 (rs1050283 G > A, rs11053646 C > G) polymorphisms and the risk of hypertension and diabetes, and try to find new candidate genes for diabetes and diabetes with hypertension etiology in Chinese population. METHODS: 574 T2DM patients and 597 controls frequently matched by age and sex were selected for genotyping of CKIP-1 (rs6693817 A > T, rs2306235 C > G) and LOX-1 gene (rs1050283 G > A, rs11053646 C > G). Logistic regression was used to analyze the correlation between different genotypes and the risk of T2DM and T2DM with hypertension, and the results were expressed as odds ratio (OR) and 95% confidence interval (95% CI). RESULTS: We found that the risk of T2DM in the AA + AT genotype of rs6693817 was higher than that in the TT genotype in Chinese population (OR = 1.318, 95%CI: 1.011-1.717, P = 0.041), and the difference was still significant after adjustment (OR = 1.370, 95%CI: 1.043-1.799, P(adjusted) = 0.024), the difference of heterozygotes (AT vs TT: OR = 1.374, 95%CI: 1.026-1.840, P(adjusted) = 0.033) was statistically significant. But after Bonferroni correction, the significance of the above sites disappeared. And rs6693817 was associated with the risk of T2DM combined with hypertension before and after adjustment in dominant model (OR = 1.424, 95% CI: 1.038-1.954, P = 0.028; OR = 1.460, 95% CI: 1.057-2.015, P(adjusted) = 0.021, respectively) and in heterozygote model (OR = 1.499, 95% CI: 1.069-2.102, P = 0.019; OR = 1.562, 95% CI: 1.106-2.207, P(adjusted) = 0.011, respectively). However, only the statistical significance of the heterozygous model remained after Bonferroni correction. rs2306235, rs1050283 and rs11053646 were not significantly correlated with T2DM and T2DM combined with hypertension risk (P > 0.05). CONCLUSIONS: The results suggest that CKIP-1 rs6693817 is related to the susceptibility of Chinese people to T2DM with hypertension, providing a new genetic target for the treatment of diabetes with hypertension with in the future. CI - (c) 2023. Springer-Verlag Italia S.r.l., part of Springer Nature. FAU - Xiong, Jiajie AU - Xiong J AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. FAU - Zhang, Liu AU - Zhang L AD - Department of Hospital Infection Management Office, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, 241000, Anhui, China. FAU - Chen, Guimei AU - Chen G AD - School of Health Management, Anhui Medical University, Hefei, 230032, Anhui, China. FAU - Dong, Pu AU - Dong P AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. FAU - Tong, Jiani AU - Tong J AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. FAU - Hua, Long AU - Hua L AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. FAU - Li, Ning AU - Li N AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. FAU - Wen, Liying AU - Wen L AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. FAU - Zhu, Lijun AU - Zhu L AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. FAU - Chang, Weiwei AU - Chang W AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. xiaowei8601@163.com. FAU - Jin, Yuelong AU - Jin Y AUID- ORCID: 0000-0002-3919-6675 AD - Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241002, Anhui, China. jinyl0803@wnmc.edu.cn. LA - eng GR - 1808085MH297/the Anhui Natural Science Foundation/ GR - 82003546/the National Natural Science Foundation of China/ GR - gxgnfx2022039/Anhui Province Excellent Young Talents Fund Program of Higher Education Institutions/ GR - No. School Administration Letter [2021] No. 46/Program of Shanghai Academic Research Leader/ PT - Journal Article DEP - 20230905 PL - Germany TA - Acta Diabetol JT - Acta diabetologica JID - 9200299 RN - 0 (Scavenger Receptors, Class E) RN - Chinese people SB - IM MH - Adult MH - Humans MH - Case-Control Studies MH - China/epidemiology MH - *Diabetes Mellitus, Type 2/epidemiology/genetics/pathology MH - *East Asian People/genetics MH - Genetic Predisposition to Disease MH - Genotype MH - Polymorphism, Single Nucleotide MH - Scavenger Receptors, Class E/genetics MH - *Hypertension/epidemiology/genetics OTO - NOTNLM OT - CKIP-1 OT - Hypertension OT - LOX-1 OT - Polymorphism OT - Type 2 diabetes mellitus EDAT- 2023/09/05 12:41 MHDA- 2024/01/24 06:43 CRDT- 2023/09/05 11:10 PHST- 2023/04/29 00:00 [received] PHST- 2023/08/18 00:00 [accepted] PHST- 2024/01/24 06:43 [medline] PHST- 2023/09/05 12:41 [pubmed] PHST- 2023/09/05 11:10 [entrez] AID - 10.1007/s00592-023-02175-z [pii] AID - 10.1007/s00592-023-02175-z [doi] PST - ppublish SO - Acta Diabetol. 2024 Jan;61(1):43-52. doi: 10.1007/s00592-023-02175-z. Epub 2023 Sep 5.