PMID- 37668849
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 43
IP  - 12
DP  - 2023 Dec
TI  - Allergen-specific IgE in the tear fluid of Chinese patients with common allergic 
      conjunctivitis in autumn and winter.
PG  - 4541-4549
LID - 10.1007/s10792-023-02854-4 [doi]
AB  - PURPOSE: In this study, we determined the positive rates of allergen-specific 
      immunoglobulin E (IgE) in the tear fluid of Chinese patients with common allergic 
      conjunctivitis (AC) in autumn and winter, compared systemic and ocular allergen 
      tests, and explored the correlation between the numbers and categories of 
      allergens and clinical AC features. METHODS: This cross-sectional study recruited 
      44 patients with AC (86 eyes). Specific IgEs for allergens common in China (house 
      dust mite, cat/dog dander, mugwort/ragweed pollen, cottonwood/willow/elm pollen, 
      milk, egg whites, soybeans) were measured in collected tears using kits for 
      allergen-specific IgE antibodies. AC signs and symptoms were graded according to 
      severity. RESULTS: Specific IgE in tears was positive in 87.2% of eyes. House 
      dust mite was the most common allergen (86.0%), followed by cat (24.4%) and dog 
      (7.0%) dander; tree and grass pollen accounted for only 4.7% and 2.3%, 
      respectively. Food allergens were not detected. The positive rates of the 
      systemic allergen tests were lower than in tear fluid tests in both eyes, 
      especially for house dust mites (P = 0.000). In patients with more allergens, 
      itching was more severe (P = 0.035), while conjunctival hyperemia was milder 
      (P = 0.002). CONCLUSION: In autumn and winter, the most common AC allergen in 
      Chinese patients was house dust mites. Compared with systemic allergen tests, 
      measuring specific IgE in tears may be a non-invasive method to diagnose and 
      evaluate AC severity, which may be more suitable to reflect the local conditions 
      of ocular surface inflammation due to its high positive rate and convenience.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Wang, Hongmei
AU  - Wang H
AD  - Department of Ophthalmology, Peking University Third Hospital Eye Center, 49 
      North Garden Rd, Haidian District, Beijing, 100191, People's Republic of China.
FAU - Jiang, Xiaodan
AU  - Jiang X
AD  - Department of Ophthalmology, Peking University Third Hospital Eye Center, 49 
      North Garden Rd, Haidian District, Beijing, 100191, People's Republic of China.
FAU - Zhang, Pei
AU  - Zhang P
AD  - Department of Ophthalmology, Peking University Third Hospital Eye Center, 49 
      North Garden Rd, Haidian District, Beijing, 100191, People's Republic of China.
FAU - Li, Yingyu
AU  - Li Y
AD  - Department of Ophthalmology, Peking University Third Hospital Eye Center, 49 
      North Garden Rd, Haidian District, Beijing, 100191, People's Republic of China.
FAU - Wang, Yiren
AU  - Wang Y
AD  - Department of Ophthalmology, Peking University Third Hospital Eye Center, 49 
      North Garden Rd, Haidian District, Beijing, 100191, People's Republic of China.
FAU - Li, Xuemin
AU  - Li X
AD  - Department of Ophthalmology, Peking University Third Hospital Eye Center, 49 
      North Garden Rd, Haidian District, Beijing, 100191, People's Republic of China. 
      lxmlxm66@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20230905
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Animals
MH  - Dogs
MH  - *Conjunctivitis, Allergic/diagnosis
MH  - Cross-Sectional Studies
MH  - Allergens
MH  - Pollen
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - Allergens
OT  - Allergic conjunctivitis
OT  - Positive rate
OT  - Specific IgE
OT  - Tear fluid
EDAT- 2023/09/05 12:41
MHDA- 2023/12/17 09:44
CRDT- 2023/09/05 11:17
PHST- 2022/06/15 00:00 [received]
PHST- 2023/08/05 00:00 [accepted]
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/09/05 12:41 [pubmed]
PHST- 2023/09/05 11:17 [entrez]
AID - 10.1007/s10792-023-02854-4 [pii]
AID - 10.1007/s10792-023-02854-4 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2023 Dec;43(12):4541-4549. doi: 10.1007/s10792-023-02854-4. Epub 
      2023 Sep 5.