PMID- 37668926
OWN - NLM
STAT- MEDLINE
DCOM- 20231002
LR  - 20240201
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 82
IP  - 2
DP  - 2023 Nov
TI  - Thymoma in multiple endocrine neoplasia type 1: a case report and systematic 
      review.
PG  - 442-449
LID - 10.1007/s12020-023-03440-5 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome that 
      combines endocrine and non-endocrine tumors. Thymic neuroendocrine tumors are 
      uncommon components that predict poor prognosis in patients with MEN1. We aimed 
      to summarize the clinical characteristics of thymoma in MEN1 by reviewing the 
      current reports from the literature. METHODS: A patient with multiple endocrine 
      neoplasia type 1 (parathyroid hyperplasia, pituitary adenoma, and insulinoma) was 
      found to have a 2 x 1.5 cm thymic mass during long-term follow-up. Thoracoscope 
      surgery was performed, and a histopathology examination revealed WHO Type B3 
      thymoma. A pathogenic mutation of c.783 + 1G > A in the MEN1 gene was identified. 
      We further searched PubMed and EMBASE for thymoma in association with MEN1. 
      RESULTS: A comprehensive overview of the literature concerning characteristics of 
      MEN1-related thymoma was summarized. Clinical characteristics and differences 
      between thymoma and thymic carcinoid are highlighted. CONCLUSIONS: Besides 
      carcinoid, other tumors, including thymoma, need to be identified for thymic 
      space-occupying lesions in MEN1 patients. The impact of thymoma on the long-term 
      prognosis of MEN1 patients needs further investigation.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Gao, Yuting
AU  - Gao Y
AD  - Key Laboratory of Endocrinology of National Health Commission, Department of 
      Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking 
      Union Medical College Hospital, Chinese Academy of Medical Science and Peking 
      Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, 100730, Beijing, 
      China.
FAU - Li, Ran
AU  - Li R
AD  - Key Laboratory of Endocrinology of National Health Commission, Department of 
      Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking 
      Union Medical College Hospital, Chinese Academy of Medical Science and Peking 
      Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, 100730, Beijing, 
      China.
FAU - Wu, Lingge
AU  - Wu L
AD  - Key Laboratory of Endocrinology of National Health Commission, Department of 
      Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking 
      Union Medical College Hospital, Chinese Academy of Medical Science and Peking 
      Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, 100730, Beijing, 
      China.
FAU - Yang, Hongbo
AU  - Yang H
AD  - Key Laboratory of Endocrinology of National Health Commission, Department of 
      Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking 
      Union Medical College Hospital, Chinese Academy of Medical Science and Peking 
      Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, 100730, Beijing, 
      China.
FAU - Mao, Jiangfeng
AU  - Mao J
AD  - Key Laboratory of Endocrinology of National Health Commission, Department of 
      Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking 
      Union Medical College Hospital, Chinese Academy of Medical Science and Peking 
      Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, 100730, Beijing, 
      China.
FAU - Zhao, Weigang
AU  - Zhao W
AUID- ORCID: 0000-0002-1472-7118
AD  - Key Laboratory of Endocrinology of National Health Commission, Department of 
      Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking 
      Union Medical College Hospital, Chinese Academy of Medical Science and Peking 
      Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, 100730, Beijing, 
      China. xiehezhaoweigang@163.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Systematic Review
DEP - 20230905
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
SB  - IM
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1/complications/genetics/diagnosis
MH  - *Thymoma/diagnostic imaging/complications
MH  - *Thymus Neoplasms
MH  - *Carcinoid Tumor/pathology
MH  - *Pancreatic Neoplasms/diagnosis
OTO - NOTNLM
OT  - MEN1
OT  - Mediastinal tumors
OT  - Multiple endocrine neoplasia type 1
OT  - Thymic neuroendocrine tumors
OT  - Thymoma
EDAT- 2023/09/05 12:41
MHDA- 2023/10/02 06:42
CRDT- 2023/09/05 11:20
PHST- 2023/05/02 00:00 [received]
PHST- 2023/06/21 00:00 [accepted]
PHST- 2023/10/02 06:42 [medline]
PHST- 2023/09/05 12:41 [pubmed]
PHST- 2023/09/05 11:20 [entrez]
AID - 10.1007/s12020-023-03440-5 [pii]
AID - 10.1007/s12020-023-03440-5 [doi]
PST - ppublish
SO  - Endocrine. 2023 Nov;82(2):442-449. doi: 10.1007/s12020-023-03440-5. Epub 2023 Sep 
      5.