PMID- 37670330
OWN - NLM
STAT- MEDLINE
DCOM- 20230907
LR  - 20231118
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 18
IP  - 1
DP  - 2023 Sep 5
TI  - Giant liposarcoma of esophagus: a rare case report.
PG  - 100
LID - 10.1186/s13000-023-01387-9 [doi]
LID - 100
AB  - BACKGROUND: Liposarcoma is a malignant mesenchymal tumor that most commonly 
      involves the retroperitoneum and lower extremities. However, liposarcoma of 
      esophagus has been rarely reported in the literature. CASE PRESENTATION: We 
      report a case of a 46-year-old man with complaint of intermittent dysphagia for 
      6 years, accompanied with paroxysmal vomiting of pedicled tumor to the mouth. 
      Imaging studies showed a huge mixed density lesion in the middle esophageal 
      lumen. Surgical resection of the tumor was performed through an external cervical 
      approach. Microscopically, the tumor was composed of mature adipocytes in normal 
      adipose tissue prominently intersected by sparsely cellular fibrous septa 
      containing atypical, enlarged spindle cells with hyperchromatic nuclei. 
      Immunohistochemically, the tumor cells were positive for Vimentin, S-100, CD34 
      and MDM2. Besides, fluorescence in situ hybridization (FISH) analysis indicated 
      the presence of amplification involving MDM2 gene. The patient was diagnosed as 
      having esophageal well-differentiated liposarcoma and recovered well after the 
      operation. CONCLUSIONS: Esophageal liposarcoma is an extremely rare tumor. Due to 
      the nonspecific clinical manifestation and lack of experience, it is challenging 
      to make a clear diagnosis before operation. Definite diagnosis of esophageal 
      liposarcoma depends on histopathology, immunohistochemistry and molecular 
      analysis.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Li, Qingjiao
AU  - Li Q
AD  - Department of Pathology, Furong District, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Hunan Province, 61 Jiefang 
      West Road, Changsha City, 410000, China. 1439060978@qq.com.
FAU - Chen, Si
AU  - Chen S
AD  - Department of Pathology, Furong District, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Hunan Province, 61 Jiefang 
      West Road, Changsha City, 410000, China. cherry3370@hunnu.edu.cn.
FAU - Li, Yanchun
AU  - Li Y
AD  - Department of Pathology, Furong District, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Hunan Province, 61 Jiefang 
      West Road, Changsha City, 410000, China.
FAU - Chen, Zhihong
AU  - Chen Z
AD  - Department of Pathology, Furong District, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Hunan Province, 61 Jiefang 
      West Road, Changsha City, 410000, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Pathology, Furong District, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Hunan Province, 61 Jiefang 
      West Road, Changsha City, 410000, China.
FAU - Guo, Wei
AU  - Guo W
AD  - Department of Pathology, Furong District, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Hunan Province, 61 Jiefang 
      West Road, Changsha City, 410000, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230905
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
SB  - IM
MH  - Humans
MH  - Male
MH  - In Situ Hybridization, Fluorescence
MH  - *Liposarcoma
MH  - *Esophageal Neoplasms
MH  - *Sarcoma
PMC - PMC10478250
OTO - NOTNLM
OT  - Case report
OT  - Esophageal liposarcoma
OT  - Esophagus
OT  - Liposarcoma
COIS- The authors declare no competing interests.
EDAT- 2023/09/06 00:41
MHDA- 2023/09/07 06:42
PMCR- 2023/09/05
CRDT- 2023/09/05 23:45
PHST- 2022/11/04 00:00 [received]
PHST- 2023/08/26 00:00 [accepted]
PHST- 2023/09/07 06:42 [medline]
PHST- 2023/09/06 00:41 [pubmed]
PHST- 2023/09/05 23:45 [entrez]
PHST- 2023/09/05 00:00 [pmc-release]
AID - 10.1186/s13000-023-01387-9 [pii]
AID - 1387 [pii]
AID - 10.1186/s13000-023-01387-9 [doi]
PST - epublish
SO  - Diagn Pathol. 2023 Sep 5;18(1):100. doi: 10.1186/s13000-023-01387-9.