PMID- 37670835 OWN - NLM STAT- MEDLINE DCOM- 20230907 LR - 20230911 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 11 DP - 2023 TI - Associations between blood essential metal mixture and serum uric acid: a cross-sectional study. PG - 1182127 LID - 10.3389/fpubh.2023.1182127 [doi] LID - 1182127 AB - INTRODUCTION: Although several studies have explored the associations between single essential metals and serum uric acid (SUA), the study about the essential metal mixture and the interactions of metals for hyperuricemia remains unclear. METHODS: We performed a cross-sectional study to explore the association of the SUA levels with the blood essential metal mixture, including magnesium (Mg), calcium (Ca), iron (Fe), copper (Cu), zinc (Zn), manganese (Mn) in Chinese community-dwelling adults (n=1039). The multivariable linear regression, the weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) were conducted to estimate the associations of blood essential metals with SUA levels and the BKMR model was also conducted to estimate the interactions of the essential metals on SUA. RESULTS: In the multivariable linear regression, the association of blood Mg, Mn, and Cu with SUA was statistically significant, both in considering multiple metals and a single metal. In WQS regression [beta=13.59 (95%CI: 5.57, 21.60)] and BKMR models, a positive association was found between the mixture of essential metals in blood and SUA. Specifically, blood Mg and Cu showed a positive association with SUA, while blood Mn showed a negative association. Additionally, no interactions between individual metals on SUA were observed. DISCUSSION: In conclusion, further attention should be paid to the relationship between the mixture of essential metals in blood and SUA. However, more studies are needed to confirm these findings. CI - Copyright (c) 2023 Wang, Li, Duan, Zhang, Liu, He, Chen, Jiang, Ma, Yu, Liu, Yao, Liang, Lin, Liu, Wan and Shen. FAU - Wang, Dongmei AU - Wang D AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Li, Yue AU - Li Y AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Duan, Hualin AU - Duan H AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Zhang, Shuting AU - Zhang S AD - Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - Liu, Lingling AU - Liu L AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - He, Yajun AU - He Y AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Chen, Xingying AU - Chen X AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Jiang, Yuqi AU - Jiang Y AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Ma, Qintao AU - Ma Q AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Yu, Genfeng AU - Yu G AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Liu, Siyang AU - Liu S AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Yao, Nanfang AU - Yao N AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Liang, Yongqian AU - Liang Y AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Lin, Xu AU - Lin X AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Liu, Lan AU - Liu L AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Wan, Heng AU - Wan H AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. FAU - Shen, Jie AU - Shen J AD - Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230821 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 268B43MJ25 (Uric Acid) RN - J41CSQ7QDS (Zinc) RN - 789U1901C5 (Copper) SB - IM MH - *Uric Acid MH - Cross-Sectional Studies MH - Bayes Theorem MH - *Zinc MH - Copper PMC - PMC10476669 OTO - NOTNLM OT - copper OT - essential metal mixture OT - interactions OT - magnesium OT - manganese OT - serum uric acid COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/09/06 06:42 MHDA- 2023/09/07 06:42 PMCR- 2023/08/21 CRDT- 2023/09/06 03:45 PHST- 2023/03/08 00:00 [received] PHST- 2023/08/02 00:00 [accepted] PHST- 2023/09/07 06:42 [medline] PHST- 2023/09/06 06:42 [pubmed] PHST- 2023/09/06 03:45 [entrez] PHST- 2023/08/21 00:00 [pmc-release] AID - 10.3389/fpubh.2023.1182127 [doi] PST - epublish SO - Front Public Health. 2023 Aug 21;11:1182127. doi: 10.3389/fpubh.2023.1182127. eCollection 2023.