PMID- 37672344 OWN - NLM STAT- MEDLINE DCOM- 20231108 LR - 20231108 IS - 1651-226X (Electronic) IS - 0284-186X (Linking) VI - 62 IP - 10 DP - 2023 Oct TI - Significant risk of second primary cancer among laryngeal squamous cell carcinoma patients even after 20 years. PG - 1322-1330 LID - 10.1080/0284186X.2023.2254482 [doi] AB - BACKGROUND: Evidence on the risk of second primary cancer (SPC) following primary laryngeal squamous cell carcinoma (LSCC) is limited, especially in Europe. METHODS: Patients diagnosed with primary LSCC from 1953-2018 were retrieved from the Finnish Cancer Registry. A total of 6241 LSCC patients were identified adding to 49,393 person-years (PY) of follow-up until the end of 2019. Only one patient emigrated and was lost to follow-up. Both standardized incidence ratios (SIR) and excess absolute risk (EAR) per 1000 person-years at risk (PYR) of second primary cancer (SPC) were calculated relative to the general population. Only non-laryngeal SPCs diagnosed six months after diagnosis of primary LSCC were included. RESULTS: A SPC was diagnosed in 1244 LSCC patients (20% of all LSCC patients) over the 65-year period, predominantly in men (92%, n = 1170). Out of all SPCs, 34% were diagnosed within 0.5 to 5 years and 66% after 5 years from primary LSCC. Among male patients, the overall SIR for SPC at any location was 1.61 (95% CI: 1.52-1.71), corresponding to 9.49 excess SPCs per 1000 PYR (95% CI: 8.19-11). The corresponding SIR for women was 1.47 (95% CI: 1.15-1.84), yielding 4.82 excess SPCs per 1000 PYR (95% CI: 2.36-9.84). The risk remained significant even after 20 years of follow-up (SIR for all 1.73, 95% CI: 1.49-2.01 and EAR 16.8 per 1000 PY, 11.88-23.75). The risk for SPC was also significantly elevated in all age groups, except <40. The highest SIRs were for SPCs arising in the mouth/pharynx (SIR for all 3.08, 95% CI: 2.36-3.95 and EAR 0.80 per 1000 PY, 0.55-1.15) and lungs (3.02, 2.75-3.30 and 5.90 per 1000, 5.13-6.78). CONCLUSION: Patients with LSCC as primary cancer have a 60% excess risk for an SPC, especially for tobacco-associated cancers, remaining significantly elevated even decades after treatment. FAU - Nikkila, Rayan AU - Nikkila R AUID- ORCID: 0000-0002-0999-2734 AD - Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland. AD - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. AD - Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Hirvonen, Elli AU - Hirvonen E AD - Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland. FAU - Haapaniemi, Aaro AU - Haapaniemi A AD - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. AD - Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Tapiovaara, Laura AU - Tapiovaara L AD - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. AD - Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Pitkaniemi, Janne AU - Pitkaniemi J AD - Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland. AD - Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland. AD - Department of Public Health, University of Helsinki, Helsinki, Finland. FAU - Malila, Nea AU - Malila N AD - Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland. FAU - Makitie, Antti AU - Makitie A AUID- ORCID: 0000-0002-0451-2404 AD - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. AD - Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. AD - Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20230906 PL - Sweden TA - Acta Oncol JT - Acta oncologica (Stockholm, Sweden) JID - 8709065 SB - IM MH - Humans MH - Male MH - Female MH - *Neoplasms, Second Primary/epidemiology MH - Squamous Cell Carcinoma of Head and Neck/complications MH - Risk Factors MH - Registries MH - Incidence MH - *Head and Neck Neoplasms/complications OAB - Although prior research on the risk of second primary cancer (SPC) among laryngeal squamous cell carcinoma (LSCC) patients has been conducted in other regions, the European perspective remains notably underrepresented. Moreover, studies on the subject focusing especially on LSCC are, even globally, only a few. The present study, with over 6000 LSCC patients followed-up over six decades, consists of the largest reported cohort of LSCC patients in Europe, and with the longest follow-up. Patients with LSCC as a primary cancer have a 60% excess risk for an SPC, which remains significantly elevated even 20 years after the diagnosis of the first primary cancer, especially for those with a tobacco/alcohol-related cancer. Healthcare professionals should be aware of the SPC risk among LSCC survivors who should be counseled about this phenomenon. OABL- eng OTO - NOTNLM OT - Head and neck cancer OT - laryngeal cancer OT - risk OT - second primary cancer EDAT- 2023/09/06 18:42 MHDA- 2023/11/08 06:44 CRDT- 2023/09/06 12:12 PHST- 2023/11/08 06:44 [medline] PHST- 2023/09/06 18:42 [pubmed] PHST- 2023/09/06 12:12 [entrez] AID - 10.1080/0284186X.2023.2254482 [doi] PST - ppublish SO - Acta Oncol. 2023 Oct;62(10):1322-1330. doi: 10.1080/0284186X.2023.2254482. Epub 2023 Sep 6.