PMID- 37672472
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20231005
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Print)
IS  - 0066-782X (Linking)
VI  - 120
IP  - 8
DP  - 2023
TI  - Stearic Acid, but not Palmitic Acid, is Associated with Inflammatory and 
      Endothelial Dysfunction Biomarkers in Individuals at Cardiovascular Risk.
PG  - e20220598
LID - S0066-782X2023000800306 [pii]
LID - 10.36660/abc.20220598 [doi]
LID - e20220598
AB  - BACKGROUND: Several studies have associated dietary saturated fatty acids (SFAs) 
      with cardiovascular risk but there are still many controversies. Most of these 
      studies have focused on the effects of palmitic acid on circulating lipids. 
      Stearic acid usually shows a neutral effect on blood lipids, however, there is a 
      lack of clinical studies assessing the link with inflammatory and endothelial 
      dysfunction markers. OBJECTIVE: To evaluate the association of red blood cell 
      (RBC) SFA (palmitic and stearic acids) with circulating inflammatory and 
      endothelial dysfunction biomarkers. METHODS: Cross-sectional study of 79 adults 
      of both sexes with at least one cardiovascular risk factor but without previous 
      events (acute myocardial infarction or stroke). Plasma biomarkers - lipids, 
      glucometabolic markers, high-sensitivity C-reactive protein (hs-CRP), 
      interleukin-6 (IL-6), interleukin-10 (IL-10), monocyte chemoattractant protein-1 
      (MCP-1), and tumor necrosis factor-alpha (TNF-alpha) - and RBC palmitic and stearic fatty 
      acids were analyzed. The associations were assessed by correlation and multiple 
      linear regression analyses, with statistical significance set at p < 0.05. 
      RESULTS: Palmitic acid showed no significant associations with traditional 
      cardiovascular risk factors or inflammatory markers. Stearic acid, on the other 
      hand, was inversely correlated with blood cholesterol and triglycerides, but 
      independently associated with hs-CRP, IL-6, and TNF-alpha. CONCLUSION: Stearic acid 
      is associated with inflammatory and endothelial dysfunction biomarkers in 
      individuals with at least one cardiovascular risk factor.
FAU - Goncalinho, Gustavo Henrique Ferreira
AU  - Goncalinho GHF
AD  - Universidade de Sao Paulo - Departamento de Nutricao , Sao Paulo , SP - Brasil.
FAU - Sampaio, Geni Rodrigues
AU  - Sampaio GR
AD  - Universidade de Sao Paulo - Departamento de Nutricao , Sao Paulo , SP - Brasil.
FAU - Soares-Freitas, Rosana Aparecida Manolio
AU  - Soares-Freitas RAM
AUID- ORCID: 0000-0001-7955-656X
AD  - Universidade de Sao Paulo - Departamento de Nutricao , Sao Paulo , SP - Brasil.
FAU - Damasceno, Nagila Raquel Teixeira
AU  - Damasceno NRT
AD  - Universidade de Sao Paulo - Departamento de Nutricao , Sao Paulo , SP - Brasil.
LA  - eng
LA  - por
PT  - Journal Article
TT  - Acido Estearico (mas nao o Acido Palmitico) esta Associado a Biomarcadores 
      Inflamatorios e de Disfuncao Endotelial em Individuos em Risco Cardiovascular.
DEP - 20230901
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
RN  - 4ELV7Z65AP (stearic acid)
RN  - 2V16EO95H1 (Palmitic Acid)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Stearic Acids)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Female
MH  - Male
MH  - Humans
MH  - Palmitic Acid
MH  - C-Reactive Protein
MH  - *Cardiovascular Diseases/etiology
MH  - Cross-Sectional Studies
MH  - Interleukin-6
MH  - Tumor Necrosis Factor-alpha
MH  - Risk Factors
MH  - Stearic Acids
MH  - Biomarkers
MH  - *Stroke
MH  - Heart Disease Risk Factors
PMC - PMC10519248
OAB - BACKGROUND: Several studies have associated dietary saturated fatty acids (SFAs) 
      with cardiovascular risk but there are still many controversies. Most of these 
      studies have focused on the effects of palmitic acid on circulating lipids. 
      Stearic acid usually shows a neutral effect on blood lipids, however, there is a 
      lack of clinical studies assessing the link with inflammatory and endothelial 
      dysfunction markers. OBJECTIVE: To evaluate the association of red blood cell 
      (RBC) SFA (palmitic and stearic acids) with circulating inflammatory and 
      endothelial dysfunction biomarkers. METHODS: Cross-sectional study of 79 adults 
      of both sexes with at least one cardiovascular risk factor but without previous 
      events (acute myocardial infarction or stroke). Plasma biomarkers - lipids, 
      glucometabolic markers, high-sensitivity C-reactive protein (hs-CRP), 
      interleukin-6 (IL-6), interleukin-10 (IL-10), monocyte chemoattractant protein-1 
      (MCP-1), and tumor necrosis factor-alpha (TNF-alpha) - and RBC palmitic and stearic fatty 
      acids were analyzed. The associations were assessed by correlation and multiple 
      linear regression analyses, with statistical significance set at p < 0.05. 
      RESULTS: Palmitic acid showed no significant associations with traditional 
      cardiovascular risk factors or inflammatory markers. Stearic acid, on the other 
      hand, was inversely correlated with blood cholesterol and triglycerides, but 
      independently associated with hs-CRP, IL-6, and TNF-alpha. CONCLUSION: Stearic acid 
      is associated with inflammatory and endothelial dysfunction biomarkers in 
      individuals with at least one cardiovascular risk factor.
OABL- eng
COIS- Potencial conflito de interesse Nao ha conflito com o presente artigo.
EDAT- 2023/09/06 18:42
MHDA- 2023/09/08 06:43
PMCR- 2023/08/10
CRDT- 2023/09/06 13:04
PHST- 2022/08/31 00:00 [received]
PHST- 2023/06/14 00:00 [accepted]
PHST- 2023/09/08 06:43 [medline]
PHST- 2023/09/06 18:42 [pubmed]
PHST- 2023/09/06 13:04 [entrez]
PHST- 2023/08/10 00:00 [pmc-release]
AID - S0066-782X2023000800306 [pii]
AID - 10.36660/abc.20220598 [doi]
PST - epublish
SO  - Arq Bras Cardiol. 2023 Sep 1;120(8):e20220598. doi: 10.36660/abc.20220598. 
      eCollection 2023.