PMID- 37672813 OWN - NLM STAT- MEDLINE DCOM- 20230927 LR - 20230927 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 341 DP - 2023 Nov TI - Exploring environmental obesogenous effects of organic ultraviolet filters on children from a case-control study. PG - 139883 LID - S0045-6535(23)02152-5 [pii] LID - 10.1016/j.chemosphere.2023.139883 [doi] AB - It has been globally recognized that obesity has become a major public health concern, especially childhood obesity. There is limited information, however, regarding the exposure risk of organic ultraviolet (UV) filters, a kind of emerging contaminant, on childhood obesity. This study would be made on 284 obese and 220 non-obese Chinese children with eight organic UV filters at urinary levels. The eight organic UV filters, including 2-Ethylhexyl 4-aminobenzoate (PABA-E), octisalate (EHS), homosalate (HMS), 2-Ethylhexyl-p-methoxycinnamate (EHMC), benzophenone-3 (BP-3), amiloxate (IAMC), octocrylene (OC) and 4-Methylbenzylidene camphor (4-MBC) were identified in urine samples with detection rates ranged from 35.32% to 100%, among which PABA-E, HMS, IAMC and OC were firstly detected in children' s urine. And the urinary UV filters concentration was associated with genders, living sites, guardian education levels, household income, and dietary factors. Urinary EHMC concentrations and childhood obesity were positively associated for girls [Adjusted OR = 2.642 (95% CI: 1.019, 6.853)], while OC concentrations and childhood obesity were negatively associated for girls [Adjusted OR = 0.022 (95% CI: 0.001, 0.817)]. The results suggest that EHMC exposure may be an environmental obesogen for girls. Moreover, two statistical models were used separately to evaluate the impact of UV filter mixtures on childhood obesity, including the Bayesian kernel machine regression (BKMR) model and the quantile g-computation (qgcomp) model. The negative association between UV filter mixtures and childhood obesity was proposed from both BKMR and qgcomp models. Further experimental and epidemiological studies are called upon to discern the individual and mixture impacts of organic UV filters on childhood obesity. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Wang, Beili AU - Wang B AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. FAU - Jin, Yihui AU - Jin Y AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. FAU - Li, Juan AU - Li J AD - Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Yang, Fan AU - Yang F AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. FAU - Lu, Hong AU - Lu H AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. FAU - Zhou, Jinyang AU - Zhou J AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. FAU - Liu, Shijian AU - Liu S AD - Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Shen, Zhemin AU - Shen Z AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. FAU - Yu, Xiaodan AU - Yu X AD - Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Yuan, Tao AU - Yuan T AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: taoyuan@sjtu.edu.cn. LA - eng PT - Journal Article DEP - 20230904 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - TL2TJE8QTX (4-Aminobenzoic Acid) RN - 8I3XWY40L9 (enzacamene) RN - 5A68WGF6WM (octocrylene) SB - IM MH - Child MH - Male MH - Humans MH - Female MH - Case-Control Studies MH - *Pediatric Obesity MH - 4-Aminobenzoic Acid MH - Bayes Theorem OTO - NOTNLM OT - Case-control study OT - Childhood obesity OT - Co-exposure OT - Organic UV filters OT - Urinary concentration COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/09/07 00:41 MHDA- 2023/09/27 06:42 CRDT- 2023/09/06 18:02 PHST- 2023/05/07 00:00 [received] PHST- 2023/07/29 00:00 [revised] PHST- 2023/08/17 00:00 [accepted] PHST- 2023/09/27 06:42 [medline] PHST- 2023/09/07 00:41 [pubmed] PHST- 2023/09/06 18:02 [entrez] AID - S0045-6535(23)02152-5 [pii] AID - 10.1016/j.chemosphere.2023.139883 [doi] PST - ppublish SO - Chemosphere. 2023 Nov;341:139883. doi: 10.1016/j.chemosphere.2023.139883. Epub 2023 Sep 4.