PMID- 37679048
OWN - NLM
STAT- MEDLINE
DCOM- 20231101
LR  - 20240328
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 101
IP  - 18
DP  - 2023 Oct 31
TI  - Mortality and Causes of Death in Children With Cerebral Palsy With Scoliosis 
      Treated With and Without Surgery.
PG  - e1787-e1792
LID - 10.1212/WNL.0000000000207796 [doi]
AB  - BACKGROUND AND OBJECTIVES: To compare mortality and causes of death in scoliotic 
      children with cerebral palsy (CP) with and without scoliosis surgery. METHODS: 
      National population-based registries were searched for children with CP and 
      scoliosis with and without surgery for scoliosis and were analyzed for 
      comorbidities, mortality, and causes of death. RESULTS: Two hundred thirty-six 
      had not been operated and 238 had been operated on for scoliosis during the 
      median follow-up of 17.8 (interquartile range [IQR] 11.7-25.7) and 23.0 (IQR 
      18.4-28.2) years, respectively. Both groups had similar comorbidities. During the 
      follow-up, mortality was higher in the nonsurgically treated group than in the 
      surgically treated group (n = 38/236, 16% and 8.7 per 1,000 follow-up years vs n 
      = 29/238, 12% and 5.3 per 1,000 follow-up years, p = 0.047). In patients with 
      nonsurgical treatment, the cause of death was respiratory in 76.3% (29/38) and 
      37.9% (11/29) in patients with surgical treatment of scoliosis (6.6 and 2.0 per 
      1,000 follow-up years, p = 0.002). Neurologic causes of death were more common in 
      surgically treated patients than in nonsurgically treated patients, 44.8% (13/29) 
      and 15.8% (6/38), respectively (3.0 and 1.1 per 1,000 follow-up years, p = 
      0.009). DISCUSSION: Surgical treatment of scoliosis associates to reduced 
      mortality because of respiratory causes in children with CP and scoliosis. 
      CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence of the effects 
      of spinal fusion on mortality of children with severe scoliosis due to CP.
CI  - (c) 2023 American Academy of Neurology.
FAU - Ahonen, Matti
AU  - Ahonen M
AUID- ORCID: 0000-0002-0330-5032
AD  - From the Helsinki University Hospital (M.A.); Department of Orthopaedics and 
      Traumatology (I.H.), University of Helsinki and Helsinki University Hospital; THL 
      Finnish Institute for Health and Welfare (M.G.); and Department of Health and 
      Welfare (I.J.-K.), Arcada University of Applied Sciences, Helsinki, Finland. 
      matti.ahonen@hus.fi.
FAU - Helenius, Ilkka
AU  - Helenius I
AD  - From the Helsinki University Hospital (M.A.); Department of Orthopaedics and 
      Traumatology (I.H.), University of Helsinki and Helsinki University Hospital; THL 
      Finnish Institute for Health and Welfare (M.G.); and Department of Health and 
      Welfare (I.J.-K.), Arcada University of Applied Sciences, Helsinki, Finland.
FAU - Gissler, Mika
AU  - Gissler M
AUID- ORCID: 0000-0001-8254-7525
AD  - From the Helsinki University Hospital (M.A.); Department of Orthopaedics and 
      Traumatology (I.H.), University of Helsinki and Helsinki University Hospital; THL 
      Finnish Institute for Health and Welfare (M.G.); and Department of Health and 
      Welfare (I.J.-K.), Arcada University of Applied Sciences, Helsinki, Finland.
FAU - Jeglinsky-Kankainen, Ira
AU  - Jeglinsky-Kankainen I
AD  - From the Helsinki University Hospital (M.A.); Department of Orthopaedics and 
      Traumatology (I.H.), University of Helsinki and Helsinki University Hospital; THL 
      Finnish Institute for Health and Welfare (M.G.); and Department of Health and 
      Welfare (I.J.-K.), Arcada University of Applied Sciences, Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230907
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
EIN - Neurology. 2024 Mar 26;102(6):e208120. PMID: 38546221
MH  - Humans
MH  - Child
MH  - *Scoliosis/complications/epidemiology/surgery
MH  - *Cerebral Palsy/complications/surgery
MH  - Cause of Death
MH  - Retrospective Studies
MH  - Causality
MH  - *Spinal Fusion/adverse effects
MH  - Treatment Outcome
PMC - PMC10634643
COIS- The authors report no relevant disclosures. Go to Neurology.org/N for full 
      disclosures.
EDAT- 2023/09/08 00:42
MHDA- 2023/11/01 12:42
PMCR- 2024/10/31
CRDT- 2023/09/07 21:23
PHST- 2023/06/01 00:00 [received]
PHST- 2023/07/06 00:00 [accepted]
PHST- 2024/10/31 00:00 [pmc-release]
PHST- 2023/11/01 12:42 [medline]
PHST- 2023/09/08 00:42 [pubmed]
PHST- 2023/09/07 21:23 [entrez]
AID - WNL.0000000000207796 [pii]
AID - WNL-2023-002244 [pii]
AID - 10.1212/WNL.0000000000207796 [doi]
PST - ppublish
SO  - Neurology. 2023 Oct 31;101(18):e1787-e1792. doi: 10.1212/WNL.0000000000207796. 
      Epub 2023 Sep 7.