PMID- 37679985
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20231016
IS  - 2589-451X (Electronic)
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 43
IP  - 5
DP  - 2023 Oct
TI  - Efficacy of catgut embedding in Baihui (GV20) and Feishu (BL13) and Pishu (BL20) 
      on lung tissue, brain tissue and blood related indexes in rats with allergic 
      rhinitis of lung deficiency type.
PG  - 973-982
LID - 10.19852/j.cnki.jtcm.2023.05.003 [doi]
AB  - OBJECTIVE: To investigate the effects of acupoint catgut embedding for 3 weeks on 
      lung tissue, blood immunoglobulin E (IgE) and interleutin-4 (IL-4), brain tissue 
      microglia x-42 (OX-42) and toll-like receptor-2 (TLR-2) in rats with allergic 
      rhinitis of lung deficiency type. METHODS: Forty-five female Sprague-Dawley rats 
      were randomly divided for two times. The first time, they were randomly divided 
      into model group and blank group (Group C) according to 2:1, and the second time, 
      the model group were randomly divided into model control group (Group B) and 
      intervention treatment group (Group A) according to 1:1. 15 in each group. For 
      Group A and Group B, the lung deficiency model was made by "sulfur-moxa 
      fumigation", and then the allergic rhinitis model was established by "ovalbumin 
      (OVA) sensitization". Then catgut embedding was performed at acupoints in Group A 
      and not in Group B. After 3 weeks, collect lung tissue samples for 
      hematoxylin-eosin staining, then take blood to observe the concentration of IgE 
      and IL-4, and finally take brain tissue to observe the results of OX-42 and 
      TLR-2. RESULTS: IgE level (mug/mL) was (3.11 +/- 0.20) in the Group A, (4.19 +/- 0.44) 
      in the Group B, and (2.29 +/- 0.30) in the Group C (all < 0.001). IL-4 level 
      (pg/mL) was (14.2 +/- 0.7) in the Group A, (18.6 +/- 2.4) in the Group B, and (11.4 +/- 
      1.2) for the Group C (all < 0.001). The mean OD for OX-42 is (0.1728 +/- 0.0016) in 
      the Group A, (0.1810 +/- 0.0046) in the Group B and (0.1674 +/- 0.0025) in the Group 
      C (all < 0.001). CONCLUSION: Although 3 weeks of acupoint catgut embedding 
      already showed obvious efficacy on rats with allergic rhinitis, the allergic 
      reaction in the body still continued. To achieve further treatment, prolonging 
      the catgut embedding time is necessary.
FAU - Heyin, Huang
AU  - Heyin H
AD  - Department of ENT, Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
FAU - Yichen, Wang
AU  - Yichen W
AD  - Department of orthopaedics, Sichuan Province Orthopaedic Hospital, Chengdu 
      610000, China.
FAU - Qinxiu, Zhang
AU  - Qinxiu Z
AD  - Department of ENT, Affiliated Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu 610000, China.
FAU - Xiaojuan, W U
AU  - Xiaojuan WU
AD  - Department of ENT, Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
FAU - Jiang, Wang
AU  - Jiang W
AD  - Department of ENT, Quxian Traditional Chinese Medicine Hospital, Quxian 635299, 
      China.
FAU - Xiangyu, Li
AU  - Xiangyu L
AD  - Department of ENT, Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
FAU - Rui, Pang
AU  - Rui P
AD  - Department of ENT, Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
FAU - Li, Fan
AU  - Li F
AD  - Department of ENT, Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
FAU - Liu, Cao
AU  - Liu C
AD  - Department of ENT, Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
FAU - Luo, Tang
AU  - Luo T
AD  - Department of ENT, Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 0 (Toll-Like Receptor 2)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Female
MH  - Rats
MH  - Animals
MH  - Rats, Sprague-Dawley
MH  - *Toll-Like Receptor 2
MH  - Catgut
MH  - Interleukin-4
MH  - *Rhinitis, Allergic/therapy
MH  - Brain
MH  - Immunoglobulin E
MH  - Lung
PMC - PMC10465844
OTO - NOTNLM
OT  - acupoint catgut embedding
OT  - enzyme-linked immunosorbent assay
OT  - hippocampus
OT  - immunoglobulin E
OT  - interleukin-4
OT  - rhinitis, allergic
OT  - toll-like receptor 2
EDAT- 2023/09/08 06:43
MHDA- 2023/09/11 06:43
PMCR- 2023/10/15
CRDT- 2023/09/08 02:08
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/09/08 06:43 [pubmed]
PHST- 2023/09/08 02:08 [entrez]
PHST- 2023/10/15 00:00 [pmc-release]
AID - 1693294247115-1561552934 [pii]
AID - 10.19852/j.cnki.jtcm.2023.05.003 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2023 Oct;43(5):973-982. doi: 10.19852/j.cnki.jtcm.2023.05.003.