PMID- 37680076
OWN - NLM
STAT- MEDLINE
DCOM- 20240416
LR  - 20240425
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Print)
IS  - 1755-5930 (Linking)
VI  - 30
IP  - 4
DP  - 2024 Apr
TI  - The role of NMDARs in the anesthetic and antidepressant effects of ketamine.
PG  - e14464
LID - 10.1111/cns.14464 [doi]
LID - e14464
AB  - BACKGROUND: As a phencyclidine (PCP) analog, ketamine can generate rapid-onset 
      and substantial anesthetic effects. Contrary to traditional anesthetics, ketamine 
      is a dissociative anesthetic and can induce loss of consciousness in patients. 
      Recently, the subanaesthetic dose of ketamine was found to produce rapid-onset 
      and lasting antidepressant effects. AIM: However, how different concentrations of 
      ketamine can induce diverse actions remains unclear. Furthermore, the molecular 
      mechanisms underlying the NMDAR-mediated anesthetic and antidepressant effects of 
      ketamine are not fully understood. METHOD: In this review, we have introduced 
      ketamine and its metabolism, summarized recent advances in the molecular 
      mechanisms underlying NMDAR inhibition in the anesthetic and antidepressant 
      effects of ketamine, explored the possible functions of NMDAR subunits in the 
      effects of ketamine, and discussed the future directions of ketamine-based 
      anesthetic and antidepressant drugs. RESULT: Both the anesthetic and 
      antidepressant effects of ketamine were thought to be mediated by 
      N-methyl-D-aspartate receptor (NMDAR) inhibition. CONCLUSION: The roles of NMDARs 
      have been extensively studied in the anaesthetic effects of ketamine. However, 
      the roles of NMDARs in antidepressant effects of ketamine are complicated and 
      controversial.
CI  - (c) 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & 
      Sons Ltd.
FAU - Zhou, Liang
AU  - Zhou L
AUID- ORCID: 0000-0003-0820-1520
AD  - Department of Pharmacology, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, China.
FAU - Duan, Jingjing
AU  - Duan J
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, SunYat-sen 
      University, Guangzhou, China.
LA  - eng
GR  - 32170975/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230907
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
RN  - 690G0D6V8H (Ketamine)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Anesthetics)
SB  - IM
MH  - Humans
MH  - *Ketamine/pharmacology/therapeutic use
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - *Anesthetics/pharmacology/therapeutic use
PMC - PMC11017467
OTO - NOTNLM
OT  - NMDARs
OT  - anesthetic effects
OT  - antidepressant effects
OT  - ketamine
OT  - metabolites
COIS- There were no conflicts of interest.
EDAT- 2023/09/08 06:43
MHDA- 2024/04/16 12:44
PMCR- 2023/09/07
CRDT- 2023/09/08 02:53
PHST- 2023/08/19 00:00 [revised]
PHST- 2023/07/09 00:00 [received]
PHST- 2023/08/26 00:00 [accepted]
PHST- 2024/04/16 12:44 [medline]
PHST- 2023/09/08 06:43 [pubmed]
PHST- 2023/09/08 02:53 [entrez]
PHST- 2023/09/07 00:00 [pmc-release]
AID - CNS14464 [pii]
AID - 10.1111/cns.14464 [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2024 Apr;30(4):e14464. doi: 10.1111/cns.14464. Epub 2023 Sep 
      7.