PMID- 37680516
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230910
IS  - 2618-6500 (Electronic)
IS  - 2148-5046 (Print)
IS  - 2148-5046 (Linking)
VI  - 38
IP  - 2
DP  - 2023 Jun
TI  - Pediatric Behcet's disease: Experience of a single tertiary center.
PG  - 282-290
LID - 10.46497/ArchRheumatol.2023.9651 [doi]
AB  - OBJECTIVES: The aim of this study was to examine the clinical and phenotypic 
      features of pediatric Behcet's disease (PEDBD) in our clinic and present the 
      rates of fulfilling the diagnostic criteria. PATIENTS AND METHODS: Thirty-four 
      patients (20 males, 14 females; mean age: 16.0+/-2.1 years; range, 10 to 18 years) 
      diagnosed with PEDBD between January 2010 and December 2019 were retrospectively 
      evaluated. Patients were reclassified according to 1990 International Study Group 
      (ISG) criteria, 2014 International Criteria for Behcet's Disease (ICBD), and 
      PEDBD criteria. RESULTS: The mean age at diagnosis was 12.6+/-3.1 years, the median 
      diagnosis delay time was 12.0 (range, 4.5 to 27.0) months, and the mean age at 
      symptom onset was 10.8+/-2.9 years. The mean follow-up period was 31.9+/-20.9 months. 
      Oral aphthous ulcer was observed in 33 (97.1%), genital ulcer in 16 (47.0%), 
      ocular involvement in 15 (44.1%), skin lesion in 11 (32.3%), joint involvement in 
      nine (26.4%), both vascular and neurological involvement in six (17.6%) patients. 
      The pathergy test was positive in 11 (37.8%) patients, and human leukocyte 
      antigen (HLA)-B51 was positive in 11 (78.5%) of 14 patients. The rates of 
      patients meeting the criteria for ISG, ICBD, and PEDBD were 52.9%, 82.4%, and 
      50.0%, respectively. CONCLUSION: Pathergy and HLA-B51 can be used as supportive 
      findings in patients who do not meet the diagnostic criteria. However, expert 
      opinion is still the gold standard in diagnosis.
CI  - Copyright (c) 2023, Turkish League Against Rheumatism.
FAU - Acari, Ceyhun
AU  - Acari C
AUID- ORCID: 0000-0002-7175-0015
AD  - Department of Pediatrics, Dokuz Eylul University Faculty of Medicine, Izmir, 
      Turkiye.
FAU - Isguder, Rana
AU  - Isguder R
AUID- ORCID: 0000-0002-6070-8196
AD  - Department of Pediatrics, Dokuz Eylul University Faculty of Medicine, Izmir, 
      Turkiye.
FAU - Torun, Ruya
AU  - Torun R
AUID- ORCID: 0000-0002-4044-1471
AD  - Department of Pediatrics, Dokuz Eylul University Faculty of Medicine, Izmir, 
      Turkiye.
FAU - Makay, Balahan
AU  - Makay B
AUID- ORCID: 0000-0001-6193-0402
AD  - Department of Pediatrics, Dokuz Eylul University Faculty of Medicine, Izmir, 
      Turkiye.
FAU - Unsal, Sevket Erbil
AU  - Unsal SE
AUID- ORCID: 0000-0002-8800-0800
AD  - Department of Pediatrics, Dokuz Eylul University Faculty of Medicine, Izmir, 
      Turkiye.
LA  - eng
PT  - Journal Article
DEP - 20221021
PL  - Turkey
TA  - Arch Rheumatol
JT  - Archives of rheumatology
JID - 101639000
PMC - PMC10481698
OTO - NOTNLM
OT  - Diagnostic criteria
OT  - HLA-B51
OT  - Pediatric Behcet's disease.
OT  - pathergy
COIS- Conflict of Interest: The authors declared no conflicts of interest with respect 
      to the authorship and/or publication of this article.
EDAT- 2023/09/08 06:43
MHDA- 2023/09/08 06:44
PMCR- 2022/10/21
CRDT- 2023/09/08 04:00
PHST- 2022/04/27 00:00 [received]
PHST- 2022/06/23 00:00 [accepted]
PHST- 2023/09/08 06:44 [medline]
PHST- 2023/09/08 06:43 [pubmed]
PHST- 2023/09/08 04:00 [entrez]
PHST- 2022/10/21 00:00 [pmc-release]
AID - 10.46497/ArchRheumatol.2023.9651 [doi]
PST - epublish
SO  - Arch Rheumatol. 2022 Oct 21;38(2):282-290. doi: 10.46497/ArchRheumatol.2023.9651. 
      eCollection 2023 Jun.