PMID- 37682269
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 2724-7031 (Electronic)
IS  - 0041-4131 (Linking)
VI  - 101
IP  - 2
DP  - 2023 Feb 11
TI  - Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
PG  - 253-258
AB  - INTRODUCTION: In adults, minimal change disease (MCD) accounts for 15 to 25% of 
      nephrotic syndrome (NS). Numerous reports have suggested a link between NS and 
      atopy. However, data on treatment and prognosis of NS associated with allergy are 
      limited. AIM: To examine the presenting characteristics, treatments and outcomes 
      of adults with allergic MCD in a North African center. METHODS: This was an 
      observational study using retrospectively collected data. Patients were recruited 
      from the Nephrology department of Sahloul Hospital (Sousse, Tunisia) from January 
      2006 to December 2020. Adults with a biopsy proved MCD, which was associated with 
      atopy, were included. RESULTS: Fifteen patients (eight males, age mean+/-SD: 34+/-13 
      years) were included. High eosinophil and immunoglobulin E (IgE) levels were 
      noted in three and twelve patients respectively. The IgE mean level at the 
      initial presentation was 1431 IU/ml. Allergic skin tests were positive in nine 
      patients. All patients were treated with corticosteroids, five had anti-histamine 
      therapy and five had hyposensitization therapy, which was successful in two 
      patients. Thirteen patients had relapsed during follow-up. Mean eosinophil level 
      was significantly higher in patients with frequent relapses compared to those 
      with infrequent relapses (5415/mm(3) vs. 239.12/mm(3), respectively, p=0.022). Two 
      patients had progressed to chronic renal failure. CONCLUSION: It is important to 
      search for atopic disorders in patients with MCD to better control this disease 
      and use specific treatments. However, the efficacy of anti-allergic therapies has 
      to be proven.
FAU - Hadhri, Asma
AU  - Hadhri A
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Mrabet, Sanda
AU  - Mrabet S
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Ben Aicha, Narjes
AU  - Ben Aicha N
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Fradi, Asma
AU  - Fradi A
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Azzabi, Awatef
AU  - Azzabi A
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Sahtout, Wissal
AU  - Sahtout W
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Boukadida, Raja
AU  - Boukadida R
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Guedri, Yosra
AU  - Guedri Y
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Zellama, Dorsaf
AU  - Zellama D
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
FAU - Abdessaied, Nihed
AU  - Abdessaied N
AD  - Department of Pathology - Farhat Hached University Hospital, Sousse, Tunisia.
FAU - Ben Saad, Helmi
AU  - Ben Saad H
AD  - Laboratory of Physiology and Functional Explorations - Farhat Hached Hospital, 
      Sousse, Tunisia.
FAU - Achour, Abdellatif
AU  - Achour A
AD  - Department of Nephrology, Dialysis, and Transplantation - Sahloul University 
      Hospital, Sousse, Tunisia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20230211
PL  - Tunisia
TA  - Tunis Med
JT  - La Tunisie medicale
JID - 0413766
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Male
MH  - Humans
MH  - Adult
MH  - Young Adult
MH  - Middle Aged
MH  - *Nephrotic Syndrome/diagnosis/epidemiology/therapy
MH  - *Nephrosis, Lipoid/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - *Hypersensitivity
MH  - Immunoglobulin E
EDAT- 2023/09/08 12:43
MHDA- 2023/09/11 06:42
CRDT- 2023/09/08 10:53
PHST- 2023/02/15 00:00 [received]
PHST- 2023/09/11 06:42 [medline]
PHST- 2023/09/08 12:43 [pubmed]
PHST- 2023/09/08 10:53 [entrez]
AID - /article/view/4415 [pii]
PST - epublish
SO  - Tunis Med. 2023 Feb 11;101(2):253-258.