PMID- 37685529
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230911
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 17
DP  - 2023 Aug 23
TI  - The Usefulness of Cellular Immune Inflammation Markers and Ultrasound Evaluation 
      in the Assessment of Disease Activity in Patients with Spondyloarthritis.
LID - 10.3390/jcm12175463 [doi]
LID - 5463
AB  - BACKGROUND: The systemic inflammation response index (SIRI) and systemic 
      immune-inflammation index (SII) have been introduced as inflammatory markers and 
      predictors of poor prognosis in cancer and cardiovascular diseases. An 
      appropriate evaluation of disease activity in spondyloarthritis (SpA) might be 
      challenging. The purpose of this study was to evaluate the usefulness of cellular 
      immune inflammation markers and ultrasound (US) evaluation of entheses and joints 
      in the assessment of disease activity in SpA patients. METHODS: This 
      cross-sectional study involved patients with SpA (62 axial SpA, 38 peripheral 
      SpA, pSpA). The clinical data of both tender, swollen joint counts, erythrocyte 
      sedimentation rate, C-reactive protein, white blood cell counts, and disease 
      activity using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and 
      Disease Activity Index for Psoriatic Arthritis (DAPSA), were recorded. The SIRI, 
      SII, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), 
      and lymphocyte-to-monocyte ratio (LMR) were calculated. US examination was 
      performed (22 small joints, Achilles tendon, and plantar aponeurosis for 
      enthesitis). RESULTS: The SII, SIRI, NLR, and PLR were higher, and LMR was lower 
      in patients with high disease activity (BASDAI > 4). Higher SII was observed in 
      pSpA patients with moderate/high disease activity (DAPSA > 14). The SIRI was 
      correlated with clinical and laboratory parameters of disease activity. The SII 
      was correlated with US parameters in pSpA. Higher SII and NLR values were found 
      in patients with signs of activity compared with no activity in the US of 
      peripheral joints. There were no associations with US changes in entheses. 
      CONCLUSIONS: The results of this study point to the value of SIRI and SII as 
      biomarkers of disease activity in patients with SpA. The SII was associated with 
      synovitis in the US of the peripheral joints.
FAU - Targonska-Stepniak, Bozena
AU  - Targonska-Stepniak B
AUID- ORCID: 0000-0003-3916-4291
AD  - Department of Rheumatology and Connective Tissue Diseases, Medical University of 
      Lublin, Jaczewskiego 8, 20-059 Lublin, Poland.
FAU - Grzechnik, Krzysztof
AU  - Grzechnik K
AD  - Department of Rheumatology and Connective Tissue Diseases, Independent Public 
      Teaching Hospital No. 4, Jaczewskiego 8, 20-059 Lublin, Poland.
LA  - eng
GR  - 395/Medical University of Lublin, Poland/
PT  - Journal Article
DEP - 20230823
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10488089
OTO - NOTNLM
OT  - cellular immune inflammation markers
OT  - spondyloarthritis
OT  - ultrasound examination
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:44
MHDA- 2023/09/09 11:45
PMCR- 2023/08/23
CRDT- 2023/09/09 01:08
PHST- 2023/07/12 00:00 [received]
PHST- 2023/08/19 00:00 [revised]
PHST- 2023/08/21 00:00 [accepted]
PHST- 2023/09/09 11:45 [medline]
PHST- 2023/09/09 11:44 [pubmed]
PHST- 2023/09/09 01:08 [entrez]
PHST- 2023/08/23 00:00 [pmc-release]
AID - jcm12175463 [pii]
AID - jcm-12-05463 [pii]
AID - 10.3390/jcm12175463 [doi]
PST - epublish
SO  - J Clin Med. 2023 Aug 23;12(17):5463. doi: 10.3390/jcm12175463.