PMID- 37685565
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230911
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 17
DP  - 2023 Aug 24
TI  - Sarcopenia in Type 2 Diabetes Mellitus: Study of the Modifiable Risk Factors 
      Involved.
LID - 10.3390/jcm12175499 [doi]
LID - 5499
AB  - (1) Background: Sarcopenia has gained much interest in recent years due to an 
      increase in morbidity. Sarcopenia is associated with type 2 diabetes mellitus 
      (T2DM) and vice versa. There is a paucity of information regarding the prevalence 
      and predictors of sarcopenia among T2DM individuals. The aim of the present study 
      was to determine the prevalence and predictors of sarcopenia among T2DM 
      individuals. (2) Methods: This study included 159 diabetics (cases) and 79 
      non-diabetics (controls) aged >50 years. The subjects were assessed for 
      demographic and anthropometric parameters. Sarcopenia (according to the Asian 
      Working Group for Sarcopenia 2019 criteria) was assessed using Jammer's hydraulic 
      dynamometer for handgrip strength, dual-energy X-ray absorptiometry for muscle 
      mass, and 6m gait speed. The biochemical investigations included glycated 
      hemoglobin; fasting and prandial glucose; fasting insulin; lipid, renal, liver, 
      and thyroid profiles; serum calcium; phosphorous; vitamin D; and parathyroid 
      hormone (PTH). Appropriate statistical methods were used to determine the 
      significance of each parameter, and a multivariate regression analysis was 
      applied to determine the predictors. (3) Results: The prevalence of sarcopenia 
      was significantly higher among the cases than the controls (22.5% vs. 8.86%, 
      p-0.012). Body mass index (BMI) (OR-0.019, CI-0.001-0.248), physical activity 
      (OR-0.45, CI-0.004-0.475), serum calcium levels (OR-0.155, CI-0.035-0.687), 
      hypertension (OR-8.739, CI-1.913-39.922), and neuropathy (OR-5.57, 
      CI-1.258-24.661) were significantly associated with sarcopenia following 
      multivariate regression analysis. (4) Conclusions: T2DM individuals are prone to 
      sarcopenia, especially those with a low BMI, low physical activity, hypertension, 
      neuropathy, and low serum calcium levels. Hence, by modifying these risk factors 
      among the elderly T2DM, sarcopenia can be prevented.
FAU - Sravya, Surapaneni Lakshmi
AU  - Sravya SL
AD  - Department of Endocrinology, IMS & SUM Hospital, Bhubaneswar 751003, India.
FAU - Swain, Jayshree
AU  - Swain J
AD  - Department of Endocrinology, IMS & SUM Hospital, Bhubaneswar 751003, India.
FAU - Sahoo, Abhay Kumar
AU  - Sahoo AK
AD  - Department of Endocrinology, IMS & SUM Hospital, Bhubaneswar 751003, India.
FAU - Mangaraj, Swayamsidha
AU  - Mangaraj S
AD  - Department of Endocrinology, IMS & SUM Hospital, Bhubaneswar 751003, India.
FAU - Kanwar, Jayabhanu
AU  - Kanwar J
AD  - Department of Endocrinology, IMS & SUM Hospital, Bhubaneswar 751003, India.
FAU - Jadhao, Pooja
AU  - Jadhao P
AUID- ORCID: 0000-0002-0012-6629
AD  - Department of Endocrinology, IMS & SUM Hospital, Bhubaneswar 751003, India.
FAU - Das, Srijit
AU  - Das S
AUID- ORCID: 0000-0001-8302-7257
AD  - Department of Human & Clinical Anatomy, College of Medicine & Health Sciences, 
      Sultan Qaboos University, Muscat 123, Oman.
LA  - eng
GR  - DRI/IMS.SH/SOA/2021/122/This work was supported by the research grant obtained 
      from Endocrine Society of India (ESI)./
PT  - Journal Article
DEP - 20230824
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10488216
OTO - NOTNLM
OT  - calcium
OT  - diabetes mellitus
OT  - hypertension
OT  - neuropathy
OT  - sarcopenia
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:46
MHDA- 2023/09/09 11:47
PMCR- 2023/08/24
CRDT- 2023/09/09 01:08
PHST- 2023/06/27 00:00 [received]
PHST- 2023/08/10 00:00 [revised]
PHST- 2023/08/20 00:00 [accepted]
PHST- 2023/09/09 11:47 [medline]
PHST- 2023/09/09 11:46 [pubmed]
PHST- 2023/09/09 01:08 [entrez]
PHST- 2023/08/24 00:00 [pmc-release]
AID - jcm12175499 [pii]
AID - jcm-12-05499 [pii]
AID - 10.3390/jcm12175499 [doi]
PST - epublish
SO  - J Clin Med. 2023 Aug 24;12(17):5499. doi: 10.3390/jcm12175499.