PMID- 37685714
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230911
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 17
DP  - 2023 Aug 30
TI  - The Possible Clinical Significance of a Decreased Serum Level of Soluble PD-L1 in 
      Discoid Lupus Erythematosus, but Not in Subacute Cutaneous Lupus Erythematosus-A 
      Pilot Study.
LID - 10.3390/jcm12175648 [doi]
LID - 5648
AB  - Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease with various 
      clinical forms, including the subtypes of discoid lupus erythematosus (DLE) and 
      subacute cutaneous lupus erythematosus (SCLE). The altered function of the 
      programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) axis in CLE 
      pathogenesis has been suggested. Here, the soluble forms of PD-1 (sPD-1) and 
      PD-L1 (sPD-L1) were explored in untreated DLE and SCLE. Levels of sPD-1 and 
      sPD-L1 were determined by enzyme-linked immunosorbent assay in serums of 21 DLE, 
      18 SCLE, 13 systemic lupus erythematosus (SLE) patients and 20 healthy controls 
      (HCs). Differences between patient groups and HCs, and the association between 
      clinical activity of skin symptoms and sPD-1/sPD-L1 levels were analyzed with 
      Mann-Whitney U-test and Spearmann's correlation. Regarding sPD-1 levels, no 
      statistically significant differences were found between DLE and SCLE groups, nor 
      compared to HCs. As for sPD-L1, a significantly lower level was found in the DLE 
      group compared to the SCLE and HC groups (p = 0.027 and p = 0.009, respectively). 
      In SLE, significantly higher sPD-1 was found compared to HCs (p = 0.002). No 
      association between skin symptom activity and sPD-1/sPD-L1 levels was found in 
      CLE. Alterations of the inhibitory effect of sPD-L1 on T-cell activity might 
      elucidate the differences between DLE and SCLE.
FAU - Kiraly, Zsofia
AU  - Kiraly Z
AUID- ORCID: 0000-0003-2513-7786
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
FAU - Nagy, Eszter
AU  - Nagy E
AD  - Department of Laboratory Medicine, Semmelweis University, 1094 Budapest, Hungary.
AD  - National Institute of Locomotor Diseases and Disabilities, 1122 Budapest, 
      Hungary.
FAU - Bokor, Laura
AU  - Bokor L
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
FAU - Kovacs, Aniko
AU  - Kovacs A
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
FAU - Marschalko, Marta
AU  - Marschalko M
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
FAU - Hidvegi, Bernadett
AU  - Hidvegi B
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
LA  - eng
PT  - Journal Article
DEP - 20230830
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10488501
OTO - NOTNLM
OT  - cutaneous lupus erythematosus
OT  - discoid lupus erythematosus
OT  - soluble PD-1
OT  - soluble PD-L1
OT  - subacute cutaneous lupus erythematosus
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:43
MHDA- 2023/09/09 11:44
PMCR- 2023/08/30
CRDT- 2023/09/09 01:09
PHST- 2023/06/26 00:00 [received]
PHST- 2023/08/13 00:00 [revised]
PHST- 2023/08/29 00:00 [accepted]
PHST- 2023/09/09 11:44 [medline]
PHST- 2023/09/09 11:43 [pubmed]
PHST- 2023/09/09 01:09 [entrez]
PHST- 2023/08/30 00:00 [pmc-release]
AID - jcm12175648 [pii]
AID - jcm-12-05648 [pii]
AID - 10.3390/jcm12175648 [doi]
PST - epublish
SO  - J Clin Med. 2023 Aug 30;12(17):5648. doi: 10.3390/jcm12175648.