PMID- 37685941
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 17
DP  - 2023 Aug 23
TI  - Present and Future of IgA Nephropathy and Membranous Nephropathy Immune 
      Monitoring: Insights from Molecular Studies.
LID - 10.3390/ijms241713134 [doi]
LID - 13134
AB  - IgA Nephropathy (IgAN) and Membranous Nephropathy (MN) are primary 
      immune-mediated glomerular diseases with highly variable prognosis. Current 
      guidelines recommend that greater immunologic activity and worse prognosis should 
      guide towards the best treatment in an individualized approach. Nevertheless, 
      proteinuria and glomerular filtration rate, the current gold standards for 
      prognosis assessment and treatment guidance in primary glomerular diseases, may 
      be altered with chronic damage and nephron scarring, conditions that are not 
      related to immune activity. In recent years, thanks to the development of new 
      molecular technologies, among them genome-wide genotyping, RNA sequencing 
      techniques, and mass spectrometry, we have witnessed an outstanding improvement 
      in understanding the pathogenesis of IgAN and MN. In addition, recent genome-wide 
      association studies have suggested potential targets for immunomodulating agents, 
      stressing the need for the identification of specific biomarkers of immune 
      activity. In this work, we aim to review current evidence and recent progress, 
      including the more recent use of omics techniques, in the identification of 
      potential biomarkers for immune monitoring in IgAN and MN.
FAU - Zanoni, Francesca
AU  - Zanoni F
AD  - Division of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca' 
      Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
FAU - Abinti, Matteo
AU  - Abinti M
AUID- ORCID: 0009-0004-8351-2307
AD  - Division of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca' 
      Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, 20122 Milan, Italy.
FAU - Belingheri, Mirco
AU  - Belingheri M
AD  - Division of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca' 
      Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
FAU - Castellano, Giuseppe
AU  - Castellano G
AD  - Division of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca' 
      Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, 20122 Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230823
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Humans
MH  - *Glomerulonephritis, IGA/genetics
MH  - *Glomerulonephritis, Membranous/genetics
MH  - Genome-Wide Association Study
MH  - Monitoring, Immunologic
MH  - Kidney Glomerulus
PMC - PMC10487514
OTO - NOTNLM
OT  - IgA nephropathy
OT  - antibodies
OT  - membranous nephropathy
OT  - monitoring
OT  - precision medicine
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:43
MHDA- 2023/09/11 06:42
PMCR- 2023/08/23
CRDT- 2023/09/09 01:10
PHST- 2023/07/05 00:00 [received]
PHST- 2023/08/13 00:00 [revised]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/09/11 06:42 [medline]
PHST- 2023/09/09 11:43 [pubmed]
PHST- 2023/09/09 01:10 [entrez]
PHST- 2023/08/23 00:00 [pmc-release]
AID - ijms241713134 [pii]
AID - ijms-24-13134 [pii]
AID - 10.3390/ijms241713134 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Aug 23;24(17):13134. doi: 10.3390/ijms241713134.