PMID- 37686189
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 17
DP  - 2023 Aug 29
TI  - Association between Human Leukocyte Antigen and End-Stage Renal Disease in 
      Patients from Transylvania, Romania.
LID - 10.3390/ijms241713383 [doi]
LID - 13383
AB  - End-stage renal disease (ESRD) is the final stage of chronic kidney disease. This 
      study explored the association between human leukocyte antigen (HLA) and ESRD. 
      The interaction between genetic and environmental factors may also play a role in 
      the development of ESRD. The study included 2392 ESRD patients who were awaiting 
      renal transplantation. Blood samples were genotyped by SSOP and SSP-PCR methods. 
      Multivariate logistic regression analysis showed that HLA-A*11 (p = 0.027), 
      HLA-A*34 (p = 0.017), HLA-A*69 (p = 0.012), HLA-B*41 (p < 0.001), HLA-B*50 (p = 
      0.004), HLA-DRB1*10 (p = 0.027), and HLA-DRB1*14 (p = 0.004) were positively 
      associated with ESRD (OR > 1); HLA-DRB1*07 (p < 0.001), HLA-DRB1*08 (p = 0.005), 
      and HLA-DRB1*13 (p < 0.001) were protective against ESRD (OR < 1); and the 
      three-locus haplotype HLA-A*02-B*41-DRB1*03, containing one susceptible allele, 
      was strongly associated with ESRD (p < 0.001, OR = 3.15). In conclusion, this 
      retrospective analysis of HLA typing in patients with ESRD of various etiologies 
      suggests that molecular data on the HLA polymorphism should be collected in order 
      to identify high-risk ESRD patients and to improve graft survival after kidney 
      transplantation.
FAU - Iancu Loga, Luminita-Ioana
AU  - Iancu Loga LI
AD  - Department of Cellular and Molecular Biology, Faculty of Medicine, 
      "Iuliu-Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, 
      Romania.
AD  - Clinical Institute of Urology and Renal Transplantation, 400000 Cluj-Napoca, 
      Romania.
FAU - Dican, Lucia
AU  - Dican L
AD  - Clinical Institute of Urology and Renal Transplantation, 400000 Cluj-Napoca, 
      Romania.
AD  - Department of Medical Biochemistry, Faculty of Medicine, "Iuliu-Hatieganu" 
      University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Chiorean, Alin Dan
AU  - Chiorean AD
AD  - Department of Cellular and Molecular Biology, Faculty of Medicine, 
      "Iuliu-Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, 
      Romania.
FAU - Chelaru, Vlad Florin
AU  - Chelaru VF
AUID- ORCID: 0000-0003-2954-3263
AD  - Department of Medical Education, Faculty of Medicine, "Iuliu-Hatieganu" 
      University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Elec, Florin Ioan
AU  - Elec FI
AUID- ORCID: 0000-0002-0803-2387
AD  - Clinical Institute of Urology and Renal Transplantation, 400000 Cluj-Napoca, 
      Romania.
AD  - Department of Urology, Faculty of Medicine, "Iuliu-Hatieganu" University of 
      Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Catana, Cristina Sorina
AU  - Catana CS
AUID- ORCID: 0000-0002-8899-6265
AD  - Department of Medical Biochemistry, Faculty of Medicine, "Iuliu-Hatieganu" 
      University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Marta, Monica Mihaela
AU  - Marta MM
AUID- ORCID: 0000-0003-2153-4493
AD  - Department of Medical Education, Faculty of Medicine, "Iuliu-Hatieganu" 
      University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Lucaciu, Roxana Liana
AU  - Lucaciu RL
AUID- ORCID: 0000-0003-4920-4760
AD  - Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of 
      Pharmacy, "Iuliu-Hatieganu" University of Medicine and Pharmacy, 400012 
      Cluj-Napoca, Romania.
FAU - Hangan, Adriana Corina
AU  - Hangan AC
AUID- ORCID: 0000-0002-0944-3161
AD  - Department of Inorganic Chemistry, Faculty of Pharmacy, "Iuliu-Hatieganu" 
      University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Bondor, Cosmina Ioana
AU  - Bondor CI
AUID- ORCID: 0000-0001-6245-4188
AD  - Department of Medical Informatics and Biostatistics, Faculty of Medicine, 
      "Iuliu-Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, 
      Romania.
FAU - Vica, Mihaela Laura
AU  - Vica ML
AUID- ORCID: 0000-0003-0811-0821
AD  - Department of Cellular and Molecular Biology, Faculty of Medicine, 
      "Iuliu-Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, 
      Romania.
FAU - Matei, Horea Vladi
AU  - Matei HV
AD  - Department of Cellular and Molecular Biology, Faculty of Medicine, 
      "Iuliu-Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, 
      Romania.
LA  - eng
PT  - Journal Article
DEP - 20230829
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Humans
MH  - Romania
MH  - HLA-DRB1 Chains/genetics
MH  - Retrospective Studies
MH  - *Histocompatibility Antigens
MH  - HLA Antigens/genetics
MH  - *Kidney Failure, Chronic/genetics
PMC - PMC10488296
OTO - NOTNLM
OT  - allele frequency
OT  - end-stage renal disease
OT  - haplotype frequency
OT  - human leukocyte antigen
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:47
MHDA- 2023/09/11 06:43
PMCR- 2023/08/29
CRDT- 2023/09/09 01:12
PHST- 2023/06/30 00:00 [received]
PHST- 2023/08/09 00:00 [revised]
PHST- 2023/08/25 00:00 [accepted]
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/09/09 11:47 [pubmed]
PHST- 2023/09/09 01:12 [entrez]
PHST- 2023/08/29 00:00 [pmc-release]
AID - ijms241713383 [pii]
AID - ijms-24-13383 [pii]
AID - 10.3390/ijms241713383 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Aug 29;24(17):13383. doi: 10.3390/ijms241713383.