PMID- 37686368
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 17
DP  - 2023 Sep 1
TI  - Association of HDL Subfraction Profile with the Progression of Insulin 
      Resistance.
LID - 10.3390/ijms241713563 [doi]
LID - 13563
AB  - Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is 
      associated with increased morbidity, mortality, and healthcare costs. Insulin 
      resistance (IR) is a condition characterized by disturbances in carbohydrate and 
      lipid metabolism that precedes T2DM. The aim of the present study was to 
      investigate the association between HDL and its subfraction profile and the 
      progression of IR, as assessed by the Homeostatic Model Assessment for IR 
      (HOMA-IR) index, and to define cut-off values to identify an increased risk of 
      IR. Individuals with a HOMA-IR greater than 3.63 were considered to have IR. The 
      HDL subfractions were separated using the Lipoprint system, which identifies ten 
      subfractions (HDL-1-10) in three subclasses as large (HDL-L), intermediate 
      (HDL-I) and small (HDL-S). Analyses were performed on samples from 240 
      individuals without IR and 137 with IR from the Hungarian general and Roma 
      populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a 
      significant negative association with the progression and existence of IR. Among 
      them, HDL-2 (B = -40.37, p = 2.08 x 10(-11)) and HDL-L (B = -14.85, p = 9.52 x 
      10(-10)) showed the strongest correlation. The optimal threshold was found to be 
      0.264 mmol/L for HDL-L and 0.102 mmol/L and above for HDL-2. Individuals with 
      HDL-L levels below the reference value had a 5.1-fold higher risk of IR (p = 2.2 
      x 10(-7)), while those with HDL-2 levels had a 4.2-fold higher risk (p = 3.0 x 
      10(-6)). This study demonstrates that the HDL subfraction profile (especially the 
      decrease in HDL-2 and -L) may be a useful marker for the early detection and 
      intervention of atherogenic dyslipidemia in subjects with impaired glucose and 
      insulin metabolism.
FAU - Piko, Peter
AU  - Piko P
AUID- ORCID: 0000-0001-5539-907X
AD  - Department of Public Health and Epidemiology, Faculty of Medicine, University of 
      Debrecen, 4032 Debrecen, Hungary.
AD  - National Laboratory for Health Security, Center for Epidemiology and 
      Surveillance, Semmelweis University, 1089 Budapest, Hungary.
FAU - Jenei, Tibor
AU  - Jenei T
AD  - Department of Public Health and Epidemiology, Faculty of Medicine, University of 
      Debrecen, 4032 Debrecen, Hungary.
FAU - Kosa, Zsigmond
AU  - Kosa Z
AD  - Department of Health Methodology and Public Health, Faculty of Health, University 
      of Debrecen, 4400 Nyiregyhaza, Hungary.
FAU - Sandor, Janos
AU  - Sandor J
AD  - Department of Public Health and Epidemiology, Faculty of Medicine, University of 
      Debrecen, 4032 Debrecen, Hungary.
AD  - ELKH-DE Public Health Research Group, Department of Public Health and 
      Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, 
      Hungary.
FAU - Kovacs, Nora
AU  - Kovacs N
AUID- ORCID: 0000-0001-9256-3756
AD  - Department of Public Health and Epidemiology, Faculty of Medicine, University of 
      Debrecen, 4032 Debrecen, Hungary.
AD  - ELKH-DE Public Health Research Group, Department of Public Health and 
      Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, 
      Hungary.
FAU - Seres, Ildiko
AU  - Seres I
AD  - Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 
      Debrecen, Hungary.
FAU - Paragh, Gyorgy
AU  - Paragh G
AD  - Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 
      Debrecen, Hungary.
FAU - Adany, Roza
AU  - Adany R
AUID- ORCID: 0000-0002-9679-6669
AD  - Department of Public Health and Epidemiology, Faculty of Medicine, University of 
      Debrecen, 4032 Debrecen, Hungary.
AD  - National Laboratory for Health Security, Center for Epidemiology and 
      Surveillance, Semmelweis University, 1089 Budapest, Hungary.
AD  - ELKH-DE Public Health Research Group, Department of Public Health and 
      Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, 
      Hungary.
AD  - Department of Public Health, Semmelweis University, 1089 Budapest, Hungary.
LA  - eng
GR  - GINOP-2.3.2-15-2016-00005/European Regional Development Fund/
GR  - TK2016-78/Hungarian Academy of Sciences/
GR  - TKCS-2021/32/Eotvos Lorand Research Network/
GR  - Project No. 135784/National Research, Development, and Innovation Fund of 
      Hungary/
GR  - RRF-2.3.1-21-2022-00006/National Research, Development and Innovation Office/
GR  - UNKP-22-4-II-DE-268/National Research, Development, and Innovation Fund of 
      Hungary/
PT  - Journal Article
DEP - 20230901
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Lipoproteins, HDL2)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - *Insulin Resistance
MH  - Lipoproteins, HDL2
MH  - Glucose
MH  - Health Care Costs
PMC - PMC10488248
OTO - NOTNLM
OT  - HDL subfraction profile
OT  - HDL-2
OT  - HOMA-IR
OT  - cut-off points
OT  - diabetes
OT  - high-density lipoprotein cholesterol
OT  - insulin resistance
OT  - large HDL
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:47
MHDA- 2023/09/11 06:42
PMCR- 2023/09/01
CRDT- 2023/09/09 01:13
PHST- 2023/07/30 00:00 [received]
PHST- 2023/08/24 00:00 [revised]
PHST- 2023/08/31 00:00 [accepted]
PHST- 2023/09/11 06:42 [medline]
PHST- 2023/09/09 11:47 [pubmed]
PHST- 2023/09/09 01:13 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - ijms241713563 [pii]
AID - ijms-24-13563 [pii]
AID - 10.3390/ijms241713563 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Sep 1;24(17):13563. doi: 10.3390/ijms241713563.