PMID- 37686743
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 17
DP  - 2023 Aug 24
TI  - Modification of Breakfast Fat Composition Can Modulate Cytokine and Other 
      Inflammatory Mediators in Women: A Randomized Crossover Trial.
LID - 10.3390/nu15173711 [doi]
LID - 3711
AB  - Previous trials have demonstrated that modifying dietary fat composition can 
      influence the production of inflammation-related factors. Additionally, it has 
      been suggested that not only the type of fat, but also the timing of fat intake 
      can impact these factors. Therefore, the objective of the present study was to 
      evaluate the effect of altering breakfast fat composition on inflammatory 
      parameters. A 3-month crossover randomized trial was designed, involving 60 
      institutionalized women who alternately consumed a breakfast rich in 
      polyunsaturated fatty acids (PUFA) (margarine), monounsaturated fatty acids 
      (MUFA) (virgin olive oil), or saturated fatty acids (SFA) (butter), based on 
      randomization. The following inflammatory markers were evaluated: epidermal 
      growth factor (EGF), interferon (IFN)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, 
      IL-6, IL-8, IL-10, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis 
      factor (TNF)-alpha, C-reactive protein (CRP), and vascular/endothelial growth factor 
      (VEGF). The results showed that the most significant effects were observed with 
      the high-MUFA breakfast, as there was a statistically significant decrease in 
      plasma IL-6 (p = 0.016) and VEGF values (p = 0.035). Other factors, such as IL-1alpha 
      and CRP, also decreased substantially, but did not reach the statistically 
      significant level. On the other hand, the high-PUFA breakfast induced a 
      significant decrease in EGF levels (p < 0.001), whereas the high-SFA breakfast 
      had no apparent effect on these factors. In conclusion, modifying breakfast fat, 
      particularly by increasing MUFA or PUFA intake, appears to be sufficient for 
      promoting a lower inflammatory marker synthesis profile and may be beneficial in 
      improving cardiovascular complications.
FAU - Delgado-Alarcon, Jessica M
AU  - Delgado-Alarcon JM
AUID- ORCID: 0000-0001-7630-9256
AD  - Department of Food Technology and Nutrition, Universidad Catolica de Murcia, 
      Campus de Los Jeronimos, Guadalupe, 30107 Murcia, Spain.
FAU - Hernandez Morante, Juan Jose
AU  - Hernandez Morante JJ
AUID- ORCID: 0000-0001-9255-4630
AD  - Eating Disorders Research Unit, Universidad Catolica de Murcia, Campus de Los 
      Jeronimos, Guadalupe, 30107 Murcia, Spain.
FAU - Morillas-Ruiz, Juana M
AU  - Morillas-Ruiz JM
AD  - Department of Food Technology and Nutrition, Universidad Catolica de Murcia, 
      Campus de Los Jeronimos, Guadalupe, 30107 Murcia, Spain.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230824
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Interferon-alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Epidermal Growth Factor
MH  - *Breakfast
MH  - Cross-Over Studies
MH  - Interleukin-6
MH  - Vascular Endothelial Growth Factor A
MH  - Interferon-alpha
MH  - Tumor Necrosis Factor-alpha
MH  - C-Reactive Protein
PMC - PMC10489665
OTO - NOTNLM
OT  - breakfast
OT  - butter
OT  - cytokine
OT  - fatty acids
OT  - inflammation
OT  - margarine
OT  - olive oil
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:46
MHDA- 2023/09/11 06:43
PMCR- 2023/08/24
CRDT- 2023/09/09 01:16
PHST- 2023/07/27 00:00 [received]
PHST- 2023/08/21 00:00 [revised]
PHST- 2023/08/22 00:00 [accepted]
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/09/09 11:46 [pubmed]
PHST- 2023/09/09 01:16 [entrez]
PHST- 2023/08/24 00:00 [pmc-release]
AID - nu15173711 [pii]
AID - nutrients-15-03711 [pii]
AID - 10.3390/nu15173711 [doi]
PST - epublish
SO  - Nutrients. 2023 Aug 24;15(17):3711. doi: 10.3390/nu15173711.