PMID- 37687223
OWN - NLM
STAT- MEDLINE
DCOM- 20240206
LR  - 20240206
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 28
IP  - 17
DP  - 2023 Sep 1
TI  - Determination of Pentachlorophenol in Seafood Samples from Zhejiang Province 
      Using Pass-Through SPE-UPLC-MS/MS: Occurrence and Human Dietary Exposure Risk.
LID - 10.3390/molecules28176394 [doi]
LID - 6394
AB  - Pentachlorophenol (PCP) has attracted wide attention due to its high toxicity, 
      persistence, and bioaccumulation. In this study, a sensitive UPLC-MS/MS method 
      for the determination of PCP in seafood samples was developed and validated. The 
      samples were ultrasonic extracted with acetonitrile containing 1% acetic 
      acid-acetonitrile and followed by using a pass-through solid-phase extraction 
      (SPE) cleanup on Captiva EMR-Lipid cartridges. The linearity of this method 
      ranged from 1 to 1000 mug/L, with regression coefficients of >0.99. The detection 
      limit and quantitation limit were 0.5 mug/kg and 1.0 mug/kg, respectively. The 
      recoveries in different types of seafood samples ranged from 86.4% to 102.5%, and 
      the intra-day and inter-day relative standard deviations (RSDs) were 3.7% to 
      11.2% and 2.9% to 12.1%, respectively (n = 6). Finally, the method has been 
      successfully utilized for the screening of PCP in 760 seafood samples from 
      Zhejiang Province. PCP was detected in 5.8% of all seafood samples, with the 
      largest portion of detections found in shellfish, accounting for approximately 
      60% of the total. The average concentrations detected ranged from 1.08 to 21.49 
      mug/kg. The non-carcinogenic risk indices for adults and children who consume PCP 
      ranged from 10(-4) to 10(-3) magnitudes. All of these indices stayed 
      significantly below 1, implying that the health risk from PCP in marine organisms 
      to humans is minimal.
FAU - Yan, Xiaoyang
AU  - Yan X
AD  - School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.
AD  - Key Laboratory of Sustainable Utilization of Technology Research for Fisheries 
      Resources of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, 
      Zhoushan 316021, China.
FAU - Zhao, Qiaoling
AU  - Zhao Q
AD  - Zhoushan Institute for Food and Drug Control, Zhoushan 316012, China.
FAU - Yan, Zhongyong
AU  - Yan Z
AD  - Zhejiang Marine Ecology and Environment Monitoring Center, Zhoushan 316021, 
      China.
FAU - Chen, Xuechang
AU  - Chen X
AD  - Key Laboratory of Sustainable Utilization of Technology Research for Fisheries 
      Resources of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, 
      Zhoushan 316021, China.
FAU - He, Pengfei
AU  - He P
AD  - Key Laboratory of Sustainable Utilization of Technology Research for Fisheries 
      Resources of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, 
      Zhoushan 316021, China.
FAU - Li, Shiyan
AU  - Li S
AD  - Zhejiang Fisheries Technology Extension Center, Hangzhou 310023, China.
FAU - Fang, Yi
AU  - Fang Y
AD  - Key Laboratory of Sustainable Utilization of Technology Research for Fisheries 
      Resources of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, 
      Zhoushan 316021, China.
LA  - eng
GR  - LGN22C200018/The Basic Public Welfare Research Program of Zhejiang Province/
PT  - Journal Article
DEP - 20230901
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Acetonitriles)
RN  - D9BSU0SE4T (Pentachlorophenol)
SB  - IM
MH  - Adult
MH  - Child
MH  - Humans
MH  - Acetonitriles
MH  - Chromatography, High Pressure Liquid
MH  - Chromatography, Liquid
MH  - Dietary Exposure
MH  - *Pentachlorophenol
MH  - Seafood
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
PMC - PMC10490177
OTO - NOTNLM
OT  - health risk
OT  - liquid chromatography-mass spectrometry
OT  - pentachlorophenol
OT  - seafood
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:47
MHDA- 2023/09/11 06:43
PMCR- 2023/09/01
CRDT- 2023/09/09 01:19
PHST- 2023/07/26 00:00 [received]
PHST- 2023/08/25 00:00 [revised]
PHST- 2023/08/30 00:00 [accepted]
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/09/09 11:47 [pubmed]
PHST- 2023/09/09 01:19 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - molecules28176394 [pii]
AID - molecules-28-06394 [pii]
AID - 10.3390/molecules28176394 [doi]
PST - epublish
SO  - Molecules. 2023 Sep 1;28(17):6394. doi: 10.3390/molecules28176394.