PMID- 37688178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230912
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 15
IP  - 17
DP  - 2023 Aug 26
TI  - Fused Deposition Modelling 3D-Printed Gastro-Retentive Floating Device for 
      Propranolol Hcl Tablets.
LID - 10.3390/polym15173554 [doi]
LID - 3554
AB  - Three-dimensional printing has revolutionized drug manufacturing and has provided 
      a solution to the limitations associated with the conventional manufacturing 
      method by designing complex drug delivery systems with customized drug release 
      profiles for personalized therapies. The present investigation aims to design a 
      gastric floating tablet with prolonged gastric floating time and sustained drug 
      release profile. In the present study, a gastro retentive floating device (GRFD) 
      was designed and fabricated using a fused deposition modelling (FDM)-based 3D 
      printing technique. This device acts as a multifunctional dosage form exhibiting 
      prolonged gastric retention time and sustained drug release profile with improved 
      oral bioavailability in the upper gastrointestinal tract. Commercial polyvinyl 
      alcohol (PVA) and polylactic acid (PLA) filaments were used to design GRFD, which 
      was comprised of dual compartments. The outer sealed compartment acts as an 
      air-filled chamber that imparts buoyancy to the device and the inner compartment 
      is filled with a commercial propranolol hydrochloride immediate-release tablet. 
      The device is designed as a round-shaped shell with a central opening of varying 
      size (1 mm, 2 mm, 3 mm, and 4 mm), which acts as a drug release window. Scanning 
      electron microscope (SEM) images were used to determine morphological 
      characterization. The in vitro buoyancy and drug release were evaluated using the 
      USP type II dissolution apparatus. All the designed GRFDs exhibit good floating 
      ability and sustained drug release profiles. GRFDs fabricated using PLA filament 
      show maximum buoyancy (>24 h) and sustained drug release for up to 10 h. The 
      floating ability and drug release from the developed devices were governed by the 
      drug release window opening size and the filament material affinity towards the 
      gastric fluid. The designed GRFDs show great prospects in modifying the drug 
      release characteristics and could be applied to any conventional 
      immediate-release product.
FAU - Alqahtani, Abdulsalam A
AU  - Alqahtani AA
AUID- ORCID: 0000-0001-7243-8042
AD  - Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 
      11001, Saudi Arabia.
FAU - Mohammed, Abdul Aleem
AU  - Mohammed AA
AUID- ORCID: 0000-0003-2601-7962
AD  - Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 
      11001, Saudi Arabia.
FAU - Fatima, Farhat
AU  - Fatima F
AUID- ORCID: 0000-0002-5783-9363
AD  - Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz 
      University, Al-Kharj 11942, Saudi Arabia.
FAU - Ahmed, Mohammed Muqtader
AU  - Ahmed MM
AUID- ORCID: 0000-0001-6911-0652
AD  - Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz 
      University, Al-Kharj 11942, Saudi Arabia.
LA  - eng
GR  - NU/DRP/MRC/12/33/Najran University/
PT  - Journal Article
DEP - 20230826
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC10490505
OTO - NOTNLM
OT  - 3D printing
OT  - PLA
OT  - PVA
OT  - dissolution kinetics
OT  - fused deposition modelling
OT  - gastro-retentive floating device
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/09 11:46
MHDA- 2023/09/09 11:47
PMCR- 2023/08/26
CRDT- 2023/09/09 01:24
PHST- 2023/06/30 00:00 [received]
PHST- 2023/08/09 00:00 [revised]
PHST- 2023/08/23 00:00 [accepted]
PHST- 2023/09/09 11:47 [medline]
PHST- 2023/09/09 11:46 [pubmed]
PHST- 2023/09/09 01:24 [entrez]
PHST- 2023/08/26 00:00 [pmc-release]
AID - polym15173554 [pii]
AID - polymers-15-03554 [pii]
AID - 10.3390/polym15173554 [doi]
PST - epublish
SO  - Polymers (Basel). 2023 Aug 26;15(17):3554. doi: 10.3390/polym15173554.