PMID- 37689501
OWN - NLM
STAT- MEDLINE
DCOM- 20231222
LR  - 20240102
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 56
IP  - 6
DP  - 2023 Dec
TI  - IgE antibody responses in cerebrospinal fluids relate to the brain pathologic 
      injury of hosts with Angiostrongylus cantonensis infection.
PG  - 1261-1272
LID - S1684-1182(23)00163-9 [pii]
LID - 10.1016/j.jmii.2023.08.012 [doi]
AB  - BACKGROUND: The immunoglobulin E (IgE) response to Angiostrongylus cantonensis 
      infection increases in the host. This study analyzed the IgG and IgE responses 
      detected in different body fluids of A. cantonensis-infected mice. METHODS: 
      BALB/c (high susceptibility), CBA (medium), and C57BL/6 and C57BL/10 (resistance) 
      strain mice were used in this study. The levels of IgM, IgG, and IgE in the serum 
      and cerebrospinal fluid (CSF) from infected mice were compared. A. 
      cantonensis-reactive antigens from BALB/c and C57BL/6 mice CSF were also 
      analyzed. RESULTS: Antibodies against fifth-stage larvae (L5) antigens increased 
      in mice CSF, particularly IgE, relate to worm rejection and the susceptibility of 
      different mouse strains. The increased IgE level in BALB/c mice CSF is lower than 
      that from others, suggesting IgE response in brain is more important than that in 
      serum. Anti-L5 and anti-excretory/secretory (ES) antigen IgE and IgG responses in 
      CSF were analyzed. In addition, the antibody-dependent eosinophil-mediated 
      cytotoxicity induced by anti-excretory/secretory (ES) antigen antibodies may be 
      the reason of severe brain inflammation in infected BALB/c mice. IgE and IgG 
      antibodies against a 105 kDa protein of L5 antigen was detected at week 3 
      post-infection in C57BL/6 mice and week 5 post-infection in BALB/c mice. We 
      suggest that 105 kDa protein is related with the antibody response of A. 
      cantonensis-infected mice. CONCLUSION: We found that IgE antibodies in mice CSF 
      against L5 antigens related to worm rejection in mice brains. This study may help 
      to identify specific angiostrongyliasis markers that can be applied for clinical 
      diagnosis and treatment in future.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Lee, Chien-Yu
AU  - Lee CY
AD  - Department of Pediatrics, Tao-Yuan General Hospital, Taoyuan, Taiwan.
FAU - Liao, Chien-Wei
AU  - Liao CW
AD  - Department of Molecular Parasitology and Tropical Diseases, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei, Taiwan; Center for 
      International Tropical Medicine, College of Medicine, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Wang, Lian-Chen
AU  - Wang LC
AD  - Department of Parasitology, College of Medicine, Chang Gung University, Taoyuan, 
      Taiwan.
FAU - Fan, Chia-Kwung
AU  - Fan CK
AD  - Department of Molecular Parasitology and Tropical Diseases, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei, Taiwan; Center for 
      International Tropical Medicine, College of Medicine, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Chuang, Ting-Wu
AU  - Chuang TW
AD  - Department of Molecular Parasitology and Tropical Diseases, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei, Taiwan; Center for 
      International Tropical Medicine, College of Medicine, Taipei Medical University, 
      Taipei, Taiwan.
FAU - En-Te Hwu, Edwin
AU  - En-Te Hwu E
AD  - The Danish National Research Foundation and Villum Foundation's Center for 
      Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, 
      Department of Health Technology, Technical University of Demark, Copenhagen, 
      Denmark.
FAU - Chao, David
AU  - Chao D
AD  - Department of Biological Science, National Sun Yat-sen University, Kaohsiung, 
      Taiwan.
FAU - Cheng, Po-Ching
AU  - Cheng PC
AD  - Department of Molecular Parasitology and Tropical Diseases, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei, Taiwan; Center for 
      International Tropical Medicine, College of Medicine, Taipei Medical University, 
      Taipei, Taiwan. Electronic address: bonjovi@tmu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20230904
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Immunoglobulin G)
RN  - Angiostrongyliasis
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Angiostrongylus cantonensis
MH  - Antibody Formation
MH  - Mice, Inbred CBA
MH  - Mice, Inbred C57BL
MH  - Immunoglobulin E
MH  - *Strongylida Infections
MH  - Brain/pathology
MH  - Immunoglobulin G
MH  - Mice, Inbred BALB C
OTO - NOTNLM
OT  - Angiostrongylus cantonensis
OT  - Brain pathologic injury
OT  - Cerebrospinal fluid
OT  - IgE
OT  - Mouse strain
COIS- Declaration of competing interest The authors do not have a commercial or other 
      association that might pose a conflict of interest.
EDAT- 2023/09/10 00:41
MHDA- 2023/12/22 06:43
CRDT- 2023/09/09 22:02
PHST- 2022/05/07 00:00 [received]
PHST- 2023/03/02 00:00 [revised]
PHST- 2023/08/28 00:00 [accepted]
PHST- 2023/12/22 06:43 [medline]
PHST- 2023/09/10 00:41 [pubmed]
PHST- 2023/09/09 22:02 [entrez]
AID - S1684-1182(23)00163-9 [pii]
AID - 10.1016/j.jmii.2023.08.012 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2023 Dec;56(6):1261-1272. doi: 
      10.1016/j.jmii.2023.08.012. Epub 2023 Sep 4.