PMID- 37689833
OWN - NLM
STAT- Publisher
LR  - 20231010
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 33
IP  - 20
DP  - 2023 Oct 9
TI  - Repetitive paired-pulse TMS increases motor cortex excitability and visuomotor 
      skill acquisition in young and older adults.
PG  - 10660-10675
LID - 10.1093/cercor/bhad315 [doi]
AB  - Transcranial magnetic stimulation (TMS) over primary motor cortex (M1) recruits 
      indirect (I) waves that can be modulated by repetitive paired-pulse TMS (rppTMS). 
      The purpose of this study was to examine the effect of rppTMS on M1 excitability 
      and visuomotor skill acquisition in young and older adults. A total of 37 healthy 
      adults (22 young, 18-32 yr; 15 older, 60-79 yr) participated in a study that 
      involved rppTMS at early (1.4 ms) and late (4.5 ms) interstimulus intervals 
      (ISIs), followed by the performance of a visuomotor training task. M1 
      excitability was examined with motor-evoked potential (MEP) amplitudes and 
      short-interval intracortical facilitation (SICF) using posterior-anterior (PA) 
      and anterior-posterior (AP) TMS current directions. We found that rppTMS 
      increased M1 excitability in young and old adults, with the greatest effects for 
      PA TMS at the late ISI (4.5 ms). Motor skill acquisition was improved by rppTMS 
      at an early (1.4 ms) but not late (4.5 ms) ISI in young and older adults. An 
      additional study using a non-I-wave interval (3.5 ms) also showed increased M1 
      excitability and visuomotor skill acquisition. These findings show that rppTMS at 
      both I-wave and non-I-wave intervals can alter M1 excitability and improve 
      visuomotor skill acquisition in young and older adults.
CI  - (c) The Author(s) 2023. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permission@oup.com.
FAU - Hand, Brodie J
AU  - Hand BJ
AD  - Discipline of Physiology, School of Biomedicine, The University of Adelaide, 
      Adelaide 5005, Australia.
FAU - Merkin, Ashley
AU  - Merkin A
AD  - Discipline of Physiology, School of Biomedicine, The University of Adelaide, 
      Adelaide 5005, Australia.
FAU - Opie, George M
AU  - Opie GM
AD  - Discipline of Physiology, School of Biomedicine, The University of Adelaide, 
      Adelaide 5005, Australia.
FAU - Ziemann, Ulf
AU  - Ziemann U
AD  - Department of Neurology & Stroke, and Hertie-Institute for Clinical Brain 
      Research, University of Tubingen, Tubingen 72076, Germany.
FAU - Semmler, John G
AU  - Semmler JG
AUID- ORCID: 0000-0003-0260-8047
AD  - Discipline of Physiology, School of Biomedicine, The University of Adelaide, 
      Adelaide 5005, Australia.
LA  - eng
GR  - DP200101009/Australian Research Council Discovery Projects/
GR  - APP1139723/National Health and Medical Research Council/
PT  - Journal Article
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
PMC - PMC10560576
OTO - NOTNLM
OT  - Aging
OT  - Plasticity
OT  - Skill acquisition
OT  - Transcranial magnetic stimulation
EDAT- 2023/09/10 00:42
MHDA- 2023/09/10 00:42
PMCR- 2023/09/08
CRDT- 2023/09/09 23:42
PHST- 2023/05/23 00:00 [received]
PHST- 2023/08/13 00:00 [revised]
PHST- 2023/08/15 00:00 [accepted]
PHST- 2023/09/10 00:42 [pubmed]
PHST- 2023/09/10 00:42 [medline]
PHST- 2023/09/09 23:42 [entrez]
PHST- 2023/09/08 00:00 [pmc-release]
AID - 7264117 [pii]
AID - bhad315 [pii]
AID - 10.1093/cercor/bhad315 [doi]
PST - ppublish
SO  - Cereb Cortex. 2023 Oct 9;33(20):10660-10675. doi: 10.1093/cercor/bhad315.