PMID- 37690541
OWN - NLM
STAT- MEDLINE
DCOM- 20231004
LR  - 20231013
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 342
DP  - 2023 Dec 1
TI  - Cognitive performance in depression in low- and middle-income countries: A 
      systematic review with meta-analytic components.
PG  - 16-32
LID - S0165-0327(23)01134-5 [pii]
LID - 10.1016/j.jad.2023.09.007 [doi]
AB  - BACKGROUND: Depression is highly prevalent in low- and middle- income countries 
      (LMIC) and associated with significant cognitive dysfunction across multiple 
      domains. However, little is known about neurocognitive tests used in people with 
      depression in LMIC. We aimed to investigate cognitive performance and cognitive 
      tests in depression research in LMIC. METHODS: APA PsycInfo, Embase, Ovid 
      MEDLINE, and Global Health were systematically searched for studies that 
      implemented a cognitive performance test in a depressed, LMIC population. Tool 
      quality was assessed using an adapted scale for quality of measures in 
      cross-cultural settings. Data extracted included demographics, depression and 
      cognitive performance measures, and cognitive performance comparisons between 
      depression and control groups. RESULTS: 29 studies met eligibility criteria, 
      involving a total of 19,100 participants from 11 LMIC. 93.1 % of studies were 
      conducted in upper middle-income countries. 67 cognitive performance tools were 
      implemented. Reliability was reported for 5.6 % of cognitive performance tests 
      and validity was reported for 8.3 %. 36.1 % of tests used were culturally 
      adapted. 75.9 % of included studies implemented at least one memory test. 
      Cognitive deficits were observed in all depressed groups, especially in memory 
      (Cohen's d = -1.60, 95 % CI -2.02 to -1.18). LIMITATIONS: Heterogeneity between 
      studies; averaged results across memory subtypes; no assessment of depression 
      severity and cognitive deficits associations; restrictive search terms. 
      CONCLUSIONS: Cognitive impairments in depression, especially in memory, are 
      prevalent in LMIC. This research has drawn attention to the burden of cognitive 
      dysfunction in depression in LMIC, and to the disparate research gap in LMIC. 
      PROSPERO registration CRD42022315397.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Thibaut, Pauline
AU  - Thibaut P
AD  - Department of Health Service & Population Research, Institute of Psychiatry, 
      Psychology and Neuroscience, King's College London, London, UK. Electronic 
      address: pauline.thibaut@kcl.ac.uk.
FAU - Mwamuka, Rukudzo
AU  - Mwamuka R
AD  - Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, 
      Zimbabwe.
FAU - Nyamayaro, Primrose
AU  - Nyamayaro P
AD  - Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, 
      Zimbabwe.
FAU - Rubin, Leah H
AU  - Rubin LH
AD  - Department of Psychiatry and Behavioural Sciences, John Hopkins University, MD, 
      USA.
FAU - Nakasujja, Noeline
AU  - Nakasujja N
AD  - Department of Psychiatry, College of Health Sciences, Makerere University, 
      Uganda.
FAU - Langenecker, Scott
AU  - Langenecker S
AD  - Department of Psychiatry, University of Utah, UT, USA.
FAU - Abas, Melanie
AU  - Abas M
AD  - Department of Health Service & Population Research, Institute of Psychiatry, 
      Psychology and Neuroscience, King's College London, London, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230909
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Humans
MH  - *Developing Countries
MH  - *Depression/diagnosis/epidemiology
MH  - Reproducibility of Results
MH  - Poverty
MH  - Cognition
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Cognitive performance measures
OT  - Low- and middle- income countries
OT  - Major depressive disorder
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/09/11 00:42
MHDA- 2023/10/04 06:44
CRDT- 2023/09/10 19:24
PHST- 2023/04/30 00:00 [received]
PHST- 2023/08/22 00:00 [revised]
PHST- 2023/09/05 00:00 [accepted]
PHST- 2023/10/04 06:44 [medline]
PHST- 2023/09/11 00:42 [pubmed]
PHST- 2023/09/10 19:24 [entrez]
AID - S0165-0327(23)01134-5 [pii]
AID - 10.1016/j.jad.2023.09.007 [doi]
PST - ppublish
SO  - J Affect Disord. 2023 Dec 1;342:16-32. doi: 10.1016/j.jad.2023.09.007. Epub 2023 
      Sep 9.