PMID- 37691364
OWN - NLM
STAT- MEDLINE
DCOM- 20230912
LR  - 20230912
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 33
IP  - 9
DP  - 2023 Sep
TI  - Comparison of Oxidant and Antioxidant Status in the Aqueous Humour of Cataract 
      Patients with and without Type 2 Diabetes Mellitus.
PG  - 1019-1022
LID - 10.29271/jcpsp.2023.09.1019 [doi]
AB  - OBJECTIVES: To compare the total oxidant status (TOS), total antioxidant capacity 
      (TAC), and oxidative stress index (OSI) in the aqueous humour of cataract 
      patients with and without type 2 diabetes mellitus (T2DM). STUDY DESIGN: 
      Cross-sectional analytical study. Place and Duration of the Study: Department of 
      Physiology, Army Medical College, National University of Medical Sciences, 
      Rawalpindi, Pakistan in collaboration with Armed Forces Institute of 
      Ophthalmology, from 1st June 2022 to 31st January 2023. METHODOLOGY: A total of 
      120 individuals were recruited and divided into 2 equal groups. Sample of aqueous 
      humour was collected, and the total oxidant status, and total antioxidant status 
      were measured by spectrophotometry. Blood samples were collected to measure the 
      fasting glucose and glycosylated haemoglobin levels. Results were analysed by 
      SPSS version 24 and p-value </=0.05 was considered significant. RESULTS: Total 
      oxidative stress and OSI were (55.57+/-5.46) vs. (33.75+/-4.28) = p (0.001), 
      (32.79+/-9.23) vs. (13.28+/-3.02) = p (0.001) found significantly increased in 
      aqueous humour of diabetic patients while TAC was reduced (1.86+/-0.41) vs. (2.62 +/- 
      0.45) = p (0.001) compared to the non-diabetics. Fasting blood glucose 
      (109.18+/-12.32 vs. 91.61+/-5.71 mg/dl, p=0.001) and glycosylated haemoglobin levels 
      (6.46+/-0.85 vs.5.43+/-0.85, p=0.001) were also found significantly high in the 
      diabetic group compared to the non-diabetics. CONCLUSION: Increased levels of 
      glucose and glycosylated haemoglobin increase oxidative stress in the blood of 
      T2DM patients. This raises the total oxidative stress in the aqueous homor while 
      lowering the TAC. This disturbed oxidant-antioxidant status in the aqueous humour 
      of diabetic patients plays an important role in the development of cataract in 
      T2DM patients compared to non-diabetics. KEY WORDS: Cataract, Aqueous humour, 
      Oxidative stress, Type 2 diabetes mellitus.
FAU - Aleem, Shoaib Bin
AU  - Aleem SB
AD  - Department of Physiology, Army Medical College, Rawalpindi, Pakistan.
FAU - Farooq, Amber
AU  - Farooq A
AD  - Department of Physiology, Army Medical College, Rawalpindi, Pakistan.
FAU - Janjua, Teyyeb Azeem
AU  - Janjua TA
AD  - Department of Ophthalmology, Armed Forces Institute of Ophthalmology, Rawalpindi, 
      Pakistan.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (Antioxidants)
RN  - 0 (Oxidants)
RN  - 0 (Glycated Hemoglobin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Humans
MH  - Antioxidants
MH  - Oxidants
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Aqueous Humor
MH  - Cross-Sectional Studies
MH  - Glycated Hemoglobin
MH  - *Cataract
MH  - Glucose
EDAT- 2023/09/11 06:42
MHDA- 2023/09/12 06:41
CRDT- 2023/09/11 02:10
PHST- 2023/02/09 00:00 [received]
PHST- 2023/05/25 00:00 [accepted]
PHST- 2023/09/12 06:41 [medline]
PHST- 2023/09/11 06:42 [pubmed]
PHST- 2023/09/11 02:10 [entrez]
AID - 040579197 [pii]
AID - 10.29271/jcpsp.2023.09.1019 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2023 Sep;33(9):1019-1022. doi: 
      10.29271/jcpsp.2023.09.1019.