PMID- 3769141
OWN - NLM
STAT- MEDLINE
DCOM- 19861210
LR  - 20190511
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 7
IP  - 11
DP  - 1986 Nov
TI  - 60Co radiation-induced transformation to anchorage independence of fibroblast 
      from normal persons and patients with inherited predisposition to retinoblastoma.
PG  - 1927-9
AB  - Retinoblastoma (RB), cancer of the retina, occurs in an inherited form which not 
      only predisposes the patient to bilateral RB, but also to the risk of developing 
      secondary tumors of mesenchymal origin (osteosarcomas and fibrosarcomas). These 
      tumors often arise in areas that were exposed to ionizing radiation during 
      therapy and fibroblasts derived from patients with hereditary RB have been 
      reported to be more sensitive than normal to the killing effects of ionizing 
      radiation. Therefore, we compared diploid fibroblast cell lines derived from two 
      hereditary RB patients (aged 1 and 3 years) with those of three normal persons 
      (two newborns and a 2 year old) for their sensitivity to ionizing 
      radiation-induced transformation to anchorage independence. The target cells were 
      exposed to 60Co radiation (1.0-3.5 Gy), allowed to undergo an expression period 
      (4-5 population doublings in 5 days), and assayed for ability to form colonies in 
      0.33% agar. There was no detectable difference between the RB cells' and the 
      normal cells' response to the transforming action of the 60Co. Both kinds of 
      cells showed a linear, dose-dependent increase in anchorage-independent cells 
      from 100 to 800/10(6) cells assayed.
FAU - Wang, Y
AU  - Wang Y
FAU - Kateley-Kohler, S
AU  - Kateley-Kohler S
FAU - Maher, V M
AU  - Maher VM
FAU - McCormick, J J
AU  - McCormick JJ
LA  - eng
GR  - CA 21253/CA/NCI NIH HHS/United States
GR  - CA 21289/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Cobalt Radioisotopes)
SB  - IM
MH  - Alleles
MH  - Cell Line
MH  - Cell Transformation, Neoplastic/*radiation effects
MH  - Child, Preschool
MH  - Cobalt Radioisotopes
MH  - Eye Neoplasms/*etiology/genetics
MH  - Female
MH  - Fibroblasts/radiation effects
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Retinoblastoma/*etiology/genetics
EDAT- 1986/11/01 00:00
MHDA- 1986/11/01 00:01
CRDT- 1986/11/01 00:00
PHST- 1986/11/01 00:00 [pubmed]
PHST- 1986/11/01 00:01 [medline]
PHST- 1986/11/01 00:00 [entrez]
AID - 10.1093/carcin/7.11.1927 [doi]
PST - ppublish
SO  - Carcinogenesis. 1986 Nov;7(11):1927-9. doi: 10.1093/carcin/7.11.1927.