PMID- 37691616
OWN - NLM
STAT- MEDLINE
DCOM- 20231005
LR  - 20231005
IS  - 1477-0539 (Electronic)
IS  - 1477-0520 (Linking)
VI  - 21
IP  - 38
DP  - 2023 Oct 4
TI  - Formulation and evaluation of anion transporters in nanostructured lipid 
      carriers.
PG  - 7753-7757
LID - 10.1039/d3ob01182h [doi]
AB  - Six novel click-tambjamines (1-6) bearing an alkyl chain of varying length linked 
      to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) 
      to evaluate their transmembrane anion transport activity both when free (i.e., 
      not encapsulated) and nanoformulated. Nanostructured lipid carriers (NLCs) are an 
      example of drug delivery systems (DDSs) that stand out because of their 
      versatility. In this work we show that NLCs can be used to efficiently formulate 
      highly lipophilic anionophores and experiments conducted in model liposomes 
      reveal that these formulations are adequate to deliver anionophores without 
      compromising their transport activity. This result paves the way to facilitate 
      the study of highly lipophilic anionophores and their potential use as future 
      drugs.
FAU - Alonso-Carrillo, Daniel
AU  - Alonso-Carrillo D
AUID- ORCID: 0000-0002-6132-8953
AD  - Departamento de Quimica, Universidad de Burgos, Burgos 09001, Spain. 
      rquesada@ubu.es.
FAU - Carreira-Barral, Israel
AU  - Carreira-Barral I
AUID- ORCID: 0000-0002-4835-8752
AD  - Departamento de Quimica, Universidad de Burgos, Burgos 09001, Spain. 
      rquesada@ubu.es.
FAU - Mielczarek, Marcin
AU  - Mielczarek M
AD  - Departamento de Quimica, Universidad de Burgos, Burgos 09001, Spain. 
      rquesada@ubu.es.
FAU - Sancho-Medina, Andrea
AU  - Sancho-Medina A
AD  - Departamento de Quimica, Universidad de Burgos, Burgos 09001, Spain. 
      rquesada@ubu.es.
FAU - Herran, Enara
AU  - Herran E
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Vairo, Claudia
AU  - Vairo C
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Del Pozo, Angel
AU  - Del Pozo A
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Luzuriaga, Iris
AU  - Luzuriaga I
AUID- ORCID: 0000-0002-3845-6754
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Lazcanoiturburu, Nerea
AU  - Lazcanoiturburu N
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Ibarrola, Oihane
AU  - Ibarrola O
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Ponce, Sara
AU  - Ponce S
AUID- ORCID: 0000-0001-6879-7448
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Villar-Vidal, Maria
AU  - Villar-Vidal M
AD  - Biokeralty Research Institute AIE, Hermanos Lumiere 5, 01510 Minano, Spain.
FAU - Garcia-Valverde, Maria
AU  - Garcia-Valverde M
AUID- ORCID: 0000-0002-3990-8388
AD  - Departamento de Quimica, Universidad de Burgos, Burgos 09001, Spain. 
      rquesada@ubu.es.
FAU - Quesada, Roberto
AU  - Quesada R
AUID- ORCID: 0000-0003-2764-7157
AD  - Departamento de Quimica, Universidad de Burgos, Burgos 09001, Spain. 
      rquesada@ubu.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231004
PL  - England
TA  - Org Biomol Chem
JT  - Organic & biomolecular chemistry
JID - 101154995
RN  - 0 (Drug Carriers)
RN  - 0 (Liposomes)
RN  - 0 (Lipids)
SB  - IM
MH  - *Drug Carriers
MH  - Drug Delivery Systems
MH  - *Nanostructures
MH  - Liposomes
MH  - Lipids
MH  - Particle Size
EDAT- 2023/09/11 06:42
MHDA- 2023/10/05 06:43
CRDT- 2023/09/11 04:13
PHST- 2023/10/05 06:43 [medline]
PHST- 2023/09/11 06:42 [pubmed]
PHST- 2023/09/11 04:13 [entrez]
AID - 10.1039/d3ob01182h [doi]
PST - epublish
SO  - Org Biomol Chem. 2023 Oct 4;21(38):7753-7757. doi: 10.1039/d3ob01182h.