PMID- 37691818 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231102 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 14 DP - 2023 TI - The overall and domain-specific quality of life of Chinese community-dwelling older adults: the role of intrinsic capacity and disease burden. PG - 1190800 LID - 10.3389/fpsyg.2023.1190800 [doi] LID - 1190800 AB - OBJECTIVE: This study aimed to investigate the impact of the different domains of intrinsic capacity (IC) and chronic disease burden on health-related quality of life (HRQoL) and domain-specific HRQoL in Chinese community-dwelling older adults. DESIGN: A cross-sectional observational study of a community-based cohort. PARTICIPANTS: We evaluated Chinese older adults (n = 429, mean age, 72.91 +/- 7.014 years; female proportion, 57.30%). MEASUREMENTS: IC contains five domains, namely locomotion, vitality, cognition, psychological, and sensory capacity. Locomotion dysfunction was defined as grip and/or gait decline. Vitality decline was defined if two of the following three parameters were present: fatigue, physical inactivity, and weight loss or overweight. Cognition was classified into normal cognition, pre-mild cognitive impairment (pre-MCI), and MCI according to the normative z-scores of the neuropsychological test battery. Psychological dysfunction was diagnosed based on depressive symptoms. Sensory dysfunction was defined as hearing and/or vision impairment. HRQoL was assessed using the AQoL-8D scale, which comprised physical (including independent living, senses, and pain) and psychosocial (including mental health, happiness, self-worth, coping, and relationships) dimensions. Low HRQoL (HRQoL score or subscores in the highest quintile) was used as a dependent variable in logistic regression analyses adjusted for demographic, health-related, and psychological confounders. RESULTS: Sensory impairment was an independent determinant of senses, and locomotion impairment was significantly associated with overall HRQoL, independent living, and pain in the physical dimension of HRQoL. Cognition was an independent determinant of the senses. Vitality was independently associated with overall HRQoL, senses, and pain in the physical dimension and mental health and relationships in the psychological dimension of HRQoL. The psychological domain of IC was independently associated with overall and domain-specific HRQoL apart from senses after adjustment for all confounders. The number of multimorbidities mainly had a significant impact on independent living after adjustment for all confounders. CONCLUSION: IC domains and chronic disease burden had heterogeneous influences on overall and domain-specific HRQoL. The impairment of sensory and locomotion domains had a synergistic impact on the overall and physical dimensions of HRQoL. The vitality and psychological domains of IC had more profound effects on HRQoL. Older people with high morbidity might have a higher risk of poor independent living. CI - Copyright (c) 2023 Hu, Ruan, Zhang, Chen, Bao, Ruan and Yu. FAU - Hu, Xiuhua AU - Hu X AD - Laboratory of Aging, Anti-aging and Cognitive Performance, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. FAU - Ruan, Jian AU - Ruan J AD - Department of Otolaryngology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. FAU - Zhang, Weibin AU - Zhang W AD - Laboratory of Aging, Anti-aging and Cognitive Performance, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. FAU - Chen, Jie AU - Chen J AD - Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. AD - Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai, China. FAU - Bao, Zhijun AU - Bao Z AD - Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. AD - Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai, China. FAU - Ruan, Qingwei AU - Ruan Q AD - Laboratory of Aging, Anti-aging and Cognitive Performance, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. AD - Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. FAU - Yu, Zhuowei AU - Yu Z AD - Laboratory of Aging, Anti-aging and Cognitive Performance, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. AD - Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China. AD - Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai, China. LA - eng PT - Journal Article DEP - 20230825 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC10485271 OTO - NOTNLM OT - demoralization OT - health-related quality of life OT - interpersonal relationships OT - intrinsic capacity OT - locomotion impairment OT - multicomorbidity OT - sensory impairment OT - vitality COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/09/11 06:43 MHDA- 2023/09/11 06:44 PMCR- 2023/08/25 CRDT- 2023/09/11 04:27 PHST- 2023/03/21 00:00 [received] PHST- 2023/08/01 00:00 [accepted] PHST- 2023/09/11 06:44 [medline] PHST- 2023/09/11 06:43 [pubmed] PHST- 2023/09/11 04:27 [entrez] PHST- 2023/08/25 00:00 [pmc-release] AID - 10.3389/fpsyg.2023.1190800 [doi] PST - epublish SO - Front Psychol. 2023 Aug 25;14:1190800. doi: 10.3389/fpsyg.2023.1190800. eCollection 2023.