PMID- 37692703
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230913
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Aug
TI  - FIP1L1-PDGFRA Clonal Hypereosinophilic Syndrome With Eosinophilic Myocarditis and 
      Intracardiac Thrombus.
PG  - e43138
LID - 10.7759/cureus.43138 [doi]
LID - e43138
AB  - A 45-year-old man from El Salvador with no past medical history presented with 
      cough and chest pain. Investigations revealed 60% peripheral eosinophilia 
      (absolute count 12.3 K/uL). Cardiac imaging was consistent with myocarditis with 
      intracardiac thrombus formation. Endomyocardial biopsy confirmed eosinophilic 
      infiltration of the myocardium, and bone marrow biopsy showed hypercellular 
      marrow with 28% eosinophils. Cytogenetics/fluorescence in situ hybridization 
      (FISH) confirmed positive FIP1L1-PDGFRA rearrangement. The patient was treated 
      for FIP1L1-PDGFRA clonal hypereosinophilic syndrome with associated eosinophilic 
      myocarditis and intracardiac thrombus. The treatment regimen consisted of a 
      steroid taper, imatinib, and anticoagulation. Treatment was followed by 
      normalization of the eosinophil count. At two-year follow-up, the patient was 
      without recurrence of eosinophilia on maintenance imatinib and indefinite 
      anticoagulation with warfarin.
CI  - Copyright (c) 2023, Locke et al.
FAU - Locke, Margaret
AU  - Locke M
AD  - Internal Medicine, Zucker School of Medicine, Hempstead, USA.
FAU - Suen, Rachel M
AU  - Suen RM
AD  - Internal Medicine, Mayo Clinic, Rochester, USA.
FAU - Williamson, Alex K
AU  - Williamson AK
AD  - Pathology, Zucker School of Medicine, Hempstead, USA.
FAU - Nieto, Maria J
AU  - Nieto MJ
AD  - Hematology, Zucker School of Medicine, Hempstead, USA.
LA  - eng
PT  - Case Reports
DEP - 20230808
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10484160
OTO - NOTNLM
OT  - clonal hypereosinophilic syndrome
OT  - eosinophilic leukemia
OT  - eosinophilic myocarditis
OT  - hypereosinophilic syndrome
OT  - intracardiac thrombus
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/09/11 06:42
MHDA- 2023/09/11 06:43
PMCR- 2023/08/08
CRDT- 2023/09/11 04:41
PHST- 2023/08/07 00:00 [accepted]
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/09/11 06:42 [pubmed]
PHST- 2023/09/11 04:41 [entrez]
PHST- 2023/08/08 00:00 [pmc-release]
AID - 10.7759/cureus.43138 [doi]
PST - epublish
SO  - Cureus. 2023 Aug 8;15(8):e43138. doi: 10.7759/cureus.43138. eCollection 2023 Aug.