PMID- 37693171
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230913
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 11
DP  - 2023
TI  - Advancements in ToF-SIMS imaging for life sciences.
PG  - 1237408
LID - 10.3389/fchem.2023.1237408 [doi]
LID - 1237408
AB  - In the last 2 decades, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) 
      has gained significant prominence as a powerful imaging technique in the field of 
      life sciences. This comprehensive review provides an in-depth overview of recent 
      advancements in ToF-SIMS instrument technology and its applications in 
      metabolomics, lipidomics, and single-cell analysis. We highlight the use of 
      ToF-SIMS imaging for studying lipid distribution, composition, and interactions 
      in cells and tissues, and discuss its application in metabolomics, including the 
      analysis of metabolic pathways. Furthermore, we review recent progress in 
      single-cell analysis using ToF-SIMS, focusing on sample preparation techniques, 
      in situ investigation for subcellular distribution of drugs, and interactions 
      between drug molecules and biological targets. The high spatial resolution and 
      potential for multimodal analysis of ToF-SIMS make it a promising tool for 
      unraveling the complex molecular landscape of biological systems. We also discuss 
      future prospects and potential advancements of ToF-SIMS in the research of life 
      sciences, with the expectation of a significant impact in the field.
CI  - Copyright (c) 2023 Jia, Zhao and Zhao.
FAU - Jia, Feifei
AU  - Jia F
AD  - National Institutes for Food and Drug Control, Beijing, China.
FAU - Zhao, Xia
AU  - Zhao X
AD  - National Institutes for Food and Drug Control, Beijing, China.
FAU - Zhao, Yao
AU  - Zhao Y
AD  - Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center 
      for Excellence in Molecular Sciences, CAS Key Laboratory of Analytical Chemistry 
      for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, 
      Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230824
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
PMC - PMC10483116
OTO - NOTNLM
OT  - ToF-SIMS
OT  - life science
OT  - lipidomics
OT  - metabolomics
OT  - single cell imaging
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/11 06:42
MHDA- 2023/09/11 06:43
PMCR- 2023/01/01
CRDT- 2023/09/11 04:48
PHST- 2023/06/09 00:00 [received]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/09/11 06:42 [pubmed]
PHST- 2023/09/11 04:48 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 1237408 [pii]
AID - 10.3389/fchem.2023.1237408 [doi]
PST - epublish
SO  - Front Chem. 2023 Aug 24;11:1237408. doi: 10.3389/fchem.2023.1237408. eCollection 
      2023.