PMID- 37694150
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240202
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 26
IP  - 9
DP  - 2023 Sep 15
TI  - Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin 
      axis.
PG  - 107647
LID - 10.1016/j.isci.2023.107647 [doi]
LID - 107647
AB  - Osteoarthritis (OA) is a prevalent degenerative disease of the elderly. The NRF2 
      antioxidant system plays a critical role in maintaining redox balance. 
      Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant. This research aimed 
      to determine whether MitoQ alleviated OA and the role of the NRF2/Parkin axis in 
      MitoQ-mediated protective effects. In interleukin (IL)-1beta-induced OA 
      chondrocytes, MitoQ activated the NRF2 pathway, reducing extracellular matrix 
      (ECM) degradation and inflammation. MitoQ also increased glutathione peroxidase 4 
      (GPX4) expression, leading to decreased levels of reactive oxygen species (ROS) 
      and lipid ROS. Silencing NRF2 weakened MitoQ's protective effects, while 
      knockdown of Parkin upregulated the NRF2 pathway, inhibiting OA progression. 
      Intra-articular injection of MitoQ mitigated cartilage destruction in 
      destabilized medial meniscus (DMM)-induced OA mice. Our study demonstrates that 
      MitoQ maintains cartilage homeostasis in vivo and in vitro through the 
      NRF2/Parkin axis. We supplemented the negative feedback regulation mechanism 
      between NRF2 and Parkin. These findings highlight the therapeutic potential of 
      MitoQ for OA treatment.
CI  - (c) 2023 The Authors.
FAU - Hou, Liangcai
AU  - Hou L
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Wang, Genchun
AU  - Wang G
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Zhang, Xiong
AU  - Zhang X
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Lu, Fan
AU  - Lu F
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Xu, Jingting
AU  - Xu J
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Guo, Zhou
AU  - Guo Z
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Lin, Jiamin
AU  - Lin J
AD  - Department of Plastic Surgery, Taizhou Hospital of Zhejiang Province Affiliated 
      to Wenzhou Medical University, Taizhou 318000, Zhejiang, P.R. China.
FAU - Zheng, Zehang
AU  - Zheng Z
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Liu, Haigang
AU  - Liu H
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Hou, Yanjun
AU  - Hou Y
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Sun, Kai
AU  - Sun K
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
FAU - Guo, Fengjing
AU  - Guo F
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei 430030, China.
LA  - eng
PT  - Journal Article
DEP - 20230815
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
EIN - iScience. 2024 Jan 22;27(2):108888. PMID: 38303700
PMC - PMC10483061
OTO - NOTNLM
OT  - Cell biology
OT  - Molecular biology
OT  - Orthopedics
COIS- The authors declare no competing interests.
EDAT- 2023/09/11 06:42
MHDA- 2023/09/11 06:43
PMCR- 2023/08/15
CRDT- 2023/09/11 05:03
PHST- 2023/01/17 00:00 [received]
PHST- 2023/07/19 00:00 [revised]
PHST- 2023/08/11 00:00 [accepted]
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/09/11 06:42 [pubmed]
PHST- 2023/09/11 05:03 [entrez]
PHST- 2023/08/15 00:00 [pmc-release]
AID - S2589-0042(23)01724-8 [pii]
AID - 107647 [pii]
AID - 10.1016/j.isci.2023.107647 [doi]
PST - epublish
SO  - iScience. 2023 Aug 15;26(9):107647. doi: 10.1016/j.isci.2023.107647. eCollection 
      2023 Sep 15.