PMID- 37694822
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 62
IP  - 44
DP  - 2023 Oct 26
TI  - N,O-Benzylidene Acetal Dipeptides (NBDs) Enable the Synthesis of Difficult 
      Peptides via a Kinked Backbone Strategy.
PG  - e202310624
LID - 10.1002/anie.202310624 [doi]
AB  - Proteins with highly hydrophobic regions or aggregation-prone sequences are 
      typically difficult targets for chemical synthesis at the current stage, as 
      obtaining such type of peptides via solid-phase peptide synthesis requires 
      sophisticated operations. Herein, we report N,O-benzylidene acetal dipeptides 
      (NBDs) as robust and effective building blocks to allow the direct synthesis of 
      difficult peptides and proteins via a kinked backbone strategy. The effectiveness 
      and easy accessibility of NBDs have been well demonstrated in our chemical 
      syntheses of various challenging peptides and proteins, including chemokine, 
      therapeutic hormones, histone, and glycosylated erythropoietin.
CI  - (c) 2023 The Authors. Angewandte Chemie International Edition published by 
      Wiley-VCH GmbH.
FAU - Wu, Hongxiang
AU  - Wu H
AD  - Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The 
      University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China.
FAU - Sun, Zhenquan
AU  - Sun Z
AD  - Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The 
      University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China.
FAU - Li, Xuechen
AU  - Li X
AUID- ORCID: 0000-0001-5465-7727
AD  - Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The 
      University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China.
AD  - Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for 
      Marine Science and Technology, School of Medicine and Pharmacy, Ocean University 
      of China, Qingdao, 266003, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20230920
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 0 (Dipeptides)
RN  - 0 (Acetals)
RN  - 0 (Peptides)
RN  - 0 (Proteins)
SB  - IM
MH  - *Dipeptides/chemistry
MH  - *Acetals
MH  - Peptides/chemistry
MH  - Proteins
MH  - Solid-Phase Synthesis Techniques
OTO - NOTNLM
OT  - Chemical Protein Synthesis
OT  - Difficult Peptide
OT  - Dipeptide Reagent
OT  - Hydrophobic Peptide
OT  - Solid-Phase Peptide Synthesis
EDAT- 2023/09/11 12:42
MHDA- 2023/10/23 00:44
CRDT- 2023/09/11 07:23
PHST- 2023/07/24 00:00 [received]
PHST- 2023/10/23 00:44 [medline]
PHST- 2023/09/11 12:42 [pubmed]
PHST- 2023/09/11 07:23 [entrez]
AID - 10.1002/anie.202310624 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2023 Oct 26;62(44):e202310624. doi: 
      10.1002/anie.202310624. Epub 2023 Sep 20.