PMID- 37695210
OWN - NLM
STAT- Publisher
LR  - 20240210
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 26
IP  - 1
DP  - 2023 Aug 22
TI  - Comparison of cytokine levels in prostatic secretion between the IIIa and IIIb 
      subtypes of prostatitis.
PG  - 77-84
LID - 10.4103/aja202336 [doi]
AB  - Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), also known as 
      National Institutes of Health (NIH) type III prostatitis, is a common disorder 
      with an unclear etiology and no known curative treatments. Based on the presence 
      or absence of leukocytes in expressed prostatic secretion (EPS), CP/CPPS is 
      classified further into IIIa (inflammatory) and IIIb (noninflammatory) subtypes. 
      However, the severity of symptoms is not entirely consistent with the white blood 
      cell (WBC) count. Following the preliminary finding of a link between 
      inflammatory cytokines and CP/CPPS, we performed this clinical study with the aim 
      of identifying cytokines that are differentially expressed according to whether 
      the prostatitis subtype is IIIa or IIIb. We found that granulocyte 
      colony-stimulating factor (G-CSF), interleukin-18 (IL-18), and monocyte 
      chemoattractant protein-1 (MCP-1) levels were significantly elevated and 
      interferon-inducible protein-10 (IP-10) and platelet-derived growth factor-BB 
      (PDGF-BB) levels were downregulated in the EPS of patients with type IIIa 
      prostatitis. In a word, it is a meaningful study in which we investigate the 
      levels of various cytokines in EPS according to whether prostatitis is the IIIa 
      or IIIb subtype. The combination of G-CSF, IL-18, MCP-1, IP-10, and PDGF-BB 
      expression levels could form a basis for classification, diagnosis, and 
      therapeutic targets in clinical CP/CPPS.
CI  - Copyright (c) 2023 Copyright: (c) The Author(s)(2023).
FAU - Han, Cheng-Lin
AU  - Han CL
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430000, China.
FAU - Deng, Yu-Xuan
AU  - Deng YX
FAU - Hu, Peng
AU  - Hu P
FAU - Hu, Bin-Tao
AU  - Hu BT
FAU - Wang, Tao
AU  - Wang T
FAU - Liu, Ji-Hong
AU  - Liu JH
FAU - Li, Ming-Chao
AU  - Li MC
LA  - eng
PT  - Journal Article
DEP - 20230822
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
SB  - IM
PMC - PMC10846828
COIS- All authors declare no competing interests.
EDAT- 2023/09/11 12:42
MHDA- 2023/09/11 12:42
PMCR- 2023/08/22
CRDT- 2023/09/11 10:02
PHST- 2023/01/29 00:00 [received]
PHST- 2023/07/02 00:00 [accepted]
PHST- 2023/09/11 12:42 [medline]
PHST- 2023/09/11 12:42 [pubmed]
PHST- 2023/09/11 10:02 [entrez]
PHST- 2023/08/22 00:00 [pmc-release]
AID - 00129336-990000000-00120 [pii]
AID - AJA-26-77 [pii]
AID - 10.4103/aja202336 [doi]
PST - aheadofprint
SO  - Asian J Androl. 2023 Aug 22;26(1):77-84. doi: 10.4103/aja202336.