PMID- 37695228
OWN - NLM
STAT- MEDLINE
DCOM- 20230912
LR  - 20230912
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 51
IP  - 5
DP  - 2023
TI  - Exposure to farm environment and its correlations with total IgE, IL-13, and 
      IL-33 serum levels in patients with atopy and asthma.
PG  - 33-40
LID - 10.15586/aei.v51i5.823 [doi]
AB  - BACKGROUND: The aim of the study was to evaluate total immunoglobulin E (IgE), 
      IL-13, and IL-33 serum level in people with bronchial asthma and atopy, and in 
      healthy control group depending on their exposure to farm animals currently and 
      in the first year of life. METHODS: The study included 174 individuals living in 
      rural areas and in a small town. Standardized questions from the International 
      Study of Asthma and Allergy in Childhood and The European Community Respiratory 
      Health Survey (ECRHS) questionnaires were used to define asthma. Atopic status 
      was verified by skin prick tests. Rural exposure including contact with livestock 
      was verified by adequate questionnaire. Total serum IgE, IL-13, and IL-33 levels 
      were assessed by ELISA (enzyme-linked immunosorbent assay) tests. RESULTS: 
      Participants with atopy and bronchial asthma were characterized by high level of 
      immunoglobulin E. Tendency to lower serum IgE level was observed among people 
      reporting present contact with farm animals. Also, among those having contact 
      with livestock in their first year of life, the analogous tendency was noticed. 
      No difference in serum IL-13 levels in participants with asthma and atopy, and 
      controls was observed, and there was no effect of exposure on farm animals on the 
      concentration of IL-13. The highest IL-33 level was found in the atopic group, 
      and the lowest in the control group. Participants currently exposed to farm 
      animals were predisposed to have lower IL-33 serum level. CONCLUSION: Exposure of 
      farm animals currently and in first year of life may result in a lower level of 
      total IgE. Correlation between IL-13 and IL-33 serum levels and contact with 
      livestock was not confirmed.
FAU - Dydak, Paulina
AU  - Dydak P
AD  - 1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical 
      University, Wroclaw, Poland; paulina_gora@wp.pl.
FAU - Sozanska, Barbara
AU  - Sozanska B
AD  - 1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical 
      University, Wroclaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20230901
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-33)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Interleukin-13
MH  - Farms
MH  - Interleukin-33
MH  - *Hypersensitivity, Immediate
MH  - *Asthma/epidemiology
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - IL-13 IL-33
OT  - asthma
OT  - atopy
OT  - farm
COIS- The authors have no conflict of interest to declare.
EDAT- 2023/09/11 12:43
MHDA- 2023/09/12 06:42
CRDT- 2023/09/11 10:03
PHST- 2023/01/09 00:00 [received]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/09/12 06:42 [medline]
PHST- 2023/09/11 12:43 [pubmed]
PHST- 2023/09/11 10:03 [entrez]
AID - 10.15586/aei.v51i5.823 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2023 Sep 1;51(5):33-40. doi: 
      10.15586/aei.v51i5.823. eCollection 2023.