PMID- 37695302
OWN - NLM
STAT- MEDLINE
DCOM- 20231129
LR  - 20240226
IS  - 1096-0929 (Electronic)
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 196
IP  - 2
DP  - 2023 Nov 28
TI  - Gestational ozone inhalation elicits maternal cardiac dysfunction and 
      transcriptional changes to placental pericytes and endothelial cells.
PG  - 238-249
LID - 10.1093/toxsci/kfad092 [doi]
AB  - Ozone (O3) is a criteria air pollutant with the most frequent incidence of 
      exceeding air quality standards. Inhalation of O3 is known to cause lung 
      inflammation and consequent systemic health effects, including endothelial 
      dysfunction. Epidemiologic data have shown that gestational exposure to air 
      pollutants correlates with complications of pregnancy, including low birth 
      weight, intrauterine growth deficiency, preeclampsia, and premature birth. 
      Mechanisms underlying how air pollution may facilitate or exacerbate gestational 
      complications remain poorly defined. The current study sought to uncover how 
      gestational O3 exposure impacted maternal cardiovascular function, as well as the 
      development of the placenta. Pregnant mice were exposed to 1PPM O3 or a sham 
      filtered air (FA) exposure for 4 h on gestational day (GD) 10.5, and evaluated 
      for cardiac function via echocardiography on GD18.5. Echocardiography revealed a 
      significant reduction in maternal stroke volume and ejection fraction in 
      maternally exposed dams. To examine the impact of maternal O3 exposure on the 
      maternal-fetal interface, placentae were analyzed by single-cell RNA sequencing 
      analysis. Mid-gestational O3 exposure led to significant differential expression 
      of 4021 transcripts compared with controls, and pericytes displayed the greatest 
      transcriptional modulation. Pathway analysis identified extracellular matrix 
      organization to be significantly altered after the exposure, with the greatest 
      modifications in trophoblasts, pericytes, and endothelial cells. This study 
      provides insights into potential molecular processes during pregnancy that may be 
      altered due to the inhalation of environmental toxicants.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Society of Toxicology. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Hunter, Russell
AU  - Hunter R
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Baird, Brenna
AU  - Baird B
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Garcia, Marcus
AU  - Garcia M
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Begay, Jessica
AU  - Begay J
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Goitom, Siem
AU  - Goitom S
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Lucas, Selita
AU  - Lucas S
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Herbert, Guy
AU  - Herbert G
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Scieszka, David
AU  - Scieszka D
AUID- ORCID: 0000-0001-9357-7121
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Padilla, Jamie
AU  - Padilla J
AD  - Department of Molecular Medicine, School of Medicine, University of New Mexico 
      Health Sciences Center, Albuquerque, New Mexico, USA.
AD  - Department of Internal Medicine, School of Medicine, University of New Mexico 
      Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Brayer, Kathryn
AU  - Brayer K
AD  - Department of Molecular Medicine, School of Medicine, University of New Mexico 
      Health Sciences Center, Albuquerque, New Mexico, USA.
AD  - Department of Internal Medicine, School of Medicine, University of New Mexico 
      Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Ottens, Andrew K
AU  - Ottens AK
AD  - Department of Anatomy and Neurobiology, Virginia Commonwealth University, 
      Richmond, Virginia, USA.
FAU - Suter, Melissa A
AU  - Suter MA
AD  - Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, 
      Texas, USA.
FAU - Barrozo, Enrico R
AU  - Barrozo ER
AD  - Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, 
      Texas, USA.
FAU - Hines, Curt
AU  - Hines C
AD  - Department of Biochemistry & Molecular Biology, University of New Mexico Health 
      Sciences Center, Albuquerque, New Mexico, USA.
FAU - Bleske, Barry
AU  - Bleske B
AD  - Department of Pharmacy Practice and Administrative Sciences, University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
FAU - Campen, Matthew J
AU  - Campen MJ
AD  - Department of Pharmaceutical Sciences, College of Pharmacy University of New 
      Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
LA  - eng
GR  - F31 HD107945/HD/NICHD NIH HHS/United States
GR  - P30 CA118100/CA/NCI NIH HHS/United States
GR  - P30 CA046934/CA/NCI NIH HHS/United States
GR  - P20 GM130422/GM/NIGMS NIH HHS/United States
GR  - R01 ES014639/ES/NIEHS NIH HHS/United States
GR  - K12 GM088021/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 66H7ZZK23N (Ozone)
RN  - 0 (Particulate Matter)
RN  - 0 (Air Pollutants)
SB  - IM
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - Animals
MH  - Mice
MH  - *Ozone
MH  - Endothelial Cells
MH  - Pericytes
MH  - Particulate Matter
MH  - Placenta
MH  - *Air Pollution
MH  - *Air Pollutants/toxicity
MH  - Maternal Exposure/adverse effects
MH  - *Heart Diseases
PMC - PMC10682975
OTO - NOTNLM
OT  - air pollution
OT  - gestational hypertension
OT  - ozone
OT  - placenta
OT  - preeclampsia
EDAT- 2023/09/11 12:43
MHDA- 2023/11/29 06:42
PMCR- 2024/09/11
CRDT- 2023/09/11 10:43
PHST- 2024/09/11 00:00 [pmc-release]
PHST- 2023/11/29 06:42 [medline]
PHST- 2023/09/11 12:43 [pubmed]
PHST- 2023/09/11 10:43 [entrez]
AID - 7268844 [pii]
AID - kfad092 [pii]
AID - 10.1093/toxsci/kfad092 [doi]
PST - ppublish
SO  - Toxicol Sci. 2023 Nov 28;196(2):238-249. doi: 10.1093/toxsci/kfad092.