PMID- 37695678
OWN - NLM
STAT- MEDLINE
DCOM- 20230926
LR  - 20230926
IS  - 1520-510X (Electronic)
IS  - 0020-1669 (Linking)
VI  - 62
IP  - 38
DP  - 2023 Sep 25
TI  - Zn(II)-Coordination Complex(s) from Chiral Bisamides of L-Phenylalanine: 
      Nanoscale-Based Biological Applications and Metallogelation.
PG  - 15777-15789
LID - 10.1021/acs.inorgchem.3c02731 [doi]
AB  - Three 3-pyridyl-containing small organic bisamide molecules attached with 
      innocent L-phenylalanine (PHE) side chain as building blocks and positional 
      isomeric toluoyl terminals (PME, MME, and OME) have rationally been designed and 
      synthesized for developing a new series of Zn(II)-coordination complexes. One of 
      the unique molecular frameworks, having two hydrogen bond-equipped monodentate 
      metal-coordinating sites and biologically potent chiral PHE moiety, was combined 
      with Zn(II) halide salts under various conditions to produce the coordination 
      complexes (CC1-CC7), thoroughly characterized by the single-crystal X-ray 
      diffraction (SXRD) technique. Maintaining the similar component ratios of 
      acquired CCs in 1:1 DMSO-water produced low-molecular weight metallogels (LMWGs) 
      of PME/MME as envisaged from a rheology- and crystal engineering-based structural 
      rationale. A structure-property correlation from the basis of PXRD of the bulk 
      and xerogels and SXRD data of the isolated single crystals of reaction products 
      clearly supports the crystal engineering-based design strategy based on which the 
      metallogels are prepared. Hand-ground nanoscale ZnCl(2)-based coordination 
      complex CC1 of PME was also studied for cytotoxicity (HEK-293 cell line) and 
      anticancer activities (B16-F10 cell line) in the MTT assay.
FAU - Manna, Utsab
AU  - Manna U
AUID- ORCID: 0000-0001-9242-5812
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science 
      (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, West Bengal 
      700032, India.
FAU - Dutta, Abhishek
AU  - Dutta A
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science 
      (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, West Bengal 
      700032, India.
FAU - Baskey, Manoj Kumar
AU  - Baskey MK
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science 
      (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, West Bengal 
      700032, India.
LA  - eng
PT  - Journal Article
DEP - 20230911
PL  - United States
TA  - Inorg Chem
JT  - Inorganic chemistry
JID - 0366543
RN  - 78185-58-7 (MME)
RN  - 0 (Coordination Complexes)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Humans
MH  - *Coordination Complexes/pharmacology
MH  - HEK293 Cells
MH  - Phenylalanine/pharmacology
MH  - Zinc
EDAT- 2023/09/11 18:41
MHDA- 2023/09/26 13:42
CRDT- 2023/09/11 12:03
PHST- 2023/09/26 13:42 [medline]
PHST- 2023/09/11 18:41 [pubmed]
PHST- 2023/09/11 12:03 [entrez]
AID - 10.1021/acs.inorgchem.3c02731 [doi]
PST - ppublish
SO  - Inorg Chem. 2023 Sep 25;62(38):15777-15789. doi: 10.1021/acs.inorgchem.3c02731. 
      Epub 2023 Sep 11.