PMID- 37697734
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 2752-7549 (Electronic)
IS  - 2752-7530 (Linking)
VI  - 41
IP  - 1
DP  - 2024 Jan-Feb
TI  - Symptom Adverse Events and Quality of Life of Children With Advanced Cancer: 
      Results From a Longitudinal Study Using the Pediatric Patient-Reported 
      Outcomes-Common Terminology Criteria for Adverse Events.
PG  - 5-15
LID - 10.1177/27527530231168588 [doi]
AB  - Background: The presence of poorly controlled symptoms negatively impacts the 
      quality of life (QoL) throughout cancer treatment. The purpose of this multisite 
      study was to explore the relationship between QoL and symptom adverse events 
      (AEs) in children with advanced cancer over 6 months. Method: A prospective and 
      longitudinal descriptive study design was used to collect QoL and symptom AE data 
      from children aged 2 to 18 with advanced cancer. QoL was measured using the 
      Pediatric Quality of Life Inventory (PedsQL(TM)) Cancer Module 3.0 and symptom 
      AEs were measured using the Pediatric Patient-Reported Outcome-Common Terminology 
      Criteria for AEs (PRO-CTCAEs((R))). Descriptive statistics were used to describe 
      QoL and symptom AE data. Correlational analyses and generalized linear mixed 
      models were used to examine the relationship between symptom AEs and QoL. 
      Results: Forty-nine children participated in the study. The mean total PedsQL(TM) 
      score was 73.86 for the sample across all time points. Children diagnosed with a 
      central nervous system (CNS) tumor reported poorer QoL compared to children 
      diagnosed with a hematologic malignancy or non-CNS solid tumor. Symptom frequency 
      AEs of anxiety, pain, nausea, insomnia, hot flashes, and fatigue severity 
      demonstrated the strongest and most significant negative correlation with total 
      QoL scores. Analyses of the relationship between QoL and symptom AEs over time 
      revealed time-specific significant differences with children who experienced 
      frequency AEs of nausea, and anxiety reporting poorer QoL at time point 4 (week 
      8). Discussion: The Ped PRO-CTCAE((R)) and PedsQL(TM) can be used to evaluate the 
      relationship between symptom AEs and QoL in practice and in future research.
FAU - Grinde, Krista
AU  - Grinde K
AD  - University of Wisconsin-Madison School of Medicine and Public Health, WI, USA.
FAU - Raybin, Jennifer L
AU  - Raybin JL
AUID- ORCID: 0000-0002-2361-2558
AD  - Schools of Medicine and Nursing, Doernbecher Children's Hospital, Oregon Health & 
      Sciences University, Portland, OR, USA. RINGGOLD: 20240
FAU - Ward, Jessica
AU  - Ward J
AUID- ORCID: 0000-0001-5262-3056
AD  - Institute for Nursing and Interprofessional Research, Children's Hospital Los 
      Angeles, Los Angeles, CA, USA.
FAU - Smith, Corey
AU  - Smith C
AD  - University of Wisconsin-Madison School of Nursing, Madison, WI, USA.
FAU - Brown, Roger
AU  - Brown R
AD  - University of Wisconsin-Madison School of Nursing, Madison, WI, USA.
FAU - Montgomery, Kathleen E
AU  - Montgomery KE
AUID- ORCID: 0000-0001-7662-0247
AD  - University of Wisconsin-Madison School of Nursing, Madison, WI, USA.
LA  - eng
PT  - Journal Article
DEP - 20230911
PL  - United States
TA  - J Pediatr Hematol Oncol Nurs
JT  - Journal of pediatric hematology/oncology nursing
JID - 9918282681506676
SB  - IM
MH  - Humans
MH  - Child
MH  - *Quality of Life
MH  - Longitudinal Studies
MH  - Prospective Studies
MH  - *Neoplasms/complications
MH  - Patient Reported Outcome Measures
MH  - Nausea/etiology
OTO - NOTNLM
OT  - pediatric cancer
OT  - quality of life
OT  - symptom experience
OT  - symptoms
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/09/12 06:41
MHDA- 2023/12/17 09:44
CRDT- 2023/09/12 02:43
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/09/12 06:41 [pubmed]
PHST- 2023/09/12 02:43 [entrez]
AID - 10.1177/27527530231168588 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol Nurs. 2024 Jan-Feb;41(1):5-15. doi: 
      10.1177/27527530231168588. Epub 2023 Sep 11.