PMID- 37697877
OWN - NLM
STAT- MEDLINE
DCOM- 20230913
LR  - 20230913
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 43
IP  - 9
DP  - 2023 Sep 12
TI  - [Effects of blistering cupping combined with thunder-fire moxibustion on the 
      efficacy and airway remodeling of cold-wheezing syndrome in bronchial asthma].
PG  - 1023-7
LID - 10.13703/j.0255-2930.20221003-k0001 [doi]
AB  - OBJECTIVE: To investigate the clinical efficacy of the combined application of 
      blistering cupping with thunder-fire moxibustion in treating bronchial asthma of 
      cold-wheezing syndrome, and its influences on airway remodeling, inflammatory 
      factors, lung function, and quality of life on the base of conventional western 
      medicine treatment. METHODS: A total of 76 patients with bronchial asthma of 
      cold-wheezing syndrome were randomly divided into an observation group and a 
      control group, 38 cases in each group. In the control group, the basic treatment 
      was used, i.e. budesonide formoterol powder inhalation. In the observation group, 
      on the basis of the treatment as the control group, blistering cupping combined 
      with thunder-fire moxibustion was supplemented, Dazhui (GV 14), Danzhong (CV 17) 
      and bilateral Feishu (BL 13), Gaohuang (BL 43), and Zhongfu (LU 1) were selected; 
      blistering cupping was administered once a day and thunder-fire moxibustion was 
      given twice a day. One course of treatment was composed of 7 days in both groups, 
      and 2 courses of treatment were required. Before and after treatment, the airway 
      remodeling indexes (matrix metalloproteinase-9 [MMP-9], tissue inhibitor of 
      matrix metalloproteinase-1 [TIMP-1], and transforming growth factor-beta1 [TGF-beta1]) 
      and inflammatory indexes (interleukin [IL] -1beta、IL-25) were detected by using 
      radioimmunoassay in the patients of the two groups. The lung function, 
      traditional Chinese medicine symptom score, and asthma quality of life 
      questionnaire (AQLQ) score were observed in the patients of the two groups. 
      RESULTS: After treatment, the serum levels of MMP-9, TIMP-1, TGF-beta1, IL-1beta, 
      IL-25, peak expiratory flow (PEFR), traditional Chinese medicine symptom scores, 
      and AQLQ scores were decreased compared with those before treatment in the 
      patients of the two groups (P<0.05), and the results in the observation group 
      were lower than those in the control group (P<0.05). After treatment, the first 
      second forced expiratory volume (FEV1) and peak expiratory flow rate (PEF) were 
      increased compared with those before treatment in the two groups (P<0.05), and 
      the results in the observation group were higher than those in the control group 
      (P<0.05). CONCLUSION: On the basis of the conventional western medicine 
      treatment, the combination of blistering cupping with thunder-fire moxibustion 
      can effectively ameliorate the clinical symptoms of patients, reduce inflammatory 
      levels, inhibit airway remodeling and improve the lung function and quality of 
      life in the patients with bronchial asthma.
FAU - Tao, Ji-En
AU  - Tao JE
AD  - Department of Acupuncture and Moxibustion, First Affiliated Hospital of Guangxi 
      University of CM, Nanning 530001, China.
FAU - Zou, Zhuo-Cheng
AU  - Zou ZC
AD  - Department of Acupuncture and Moxibustion, First Affiliated Hospital of Guangxi 
      University of CM, Nanning 530001, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
SB  - IM
MH  - Humans
MH  - Airway Remodeling
MH  - Respiratory Sounds
MH  - Matrix Metalloproteinase 9
MH  - Transforming Growth Factor beta1
MH  - *Moxibustion
MH  - Quality of Life
MH  - Tissue Inhibitor of Metalloproteinase-1
MH  - *Asthma/therapy
OTO - NOTNLM
OT  - airway remodeling
OT  - blistering cupping
OT  - bronchial asthma
OT  - cold-wheezing syndrome
OT  - inflammatory factors
OT  - randomized controlled trial (RCT)
OT  - thunder-fire moxibustion
EDAT- 2023/09/12 06:41
MHDA- 2023/09/13 06:41
CRDT- 2023/09/12 03:34
PHST- 2023/09/13 06:41 [medline]
PHST- 2023/09/12 06:41 [pubmed]
PHST- 2023/09/12 03:34 [entrez]
AID - 10.13703/j.0255-2930.20221003-k0001 [doi]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2023 Sep 12;43(9):1023-7. doi: 
      10.13703/j.0255-2930.20221003-k0001.